hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00284
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TUBA1C | Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | UniProt NCBI |
| TUBB6 | Tubulin beta-6 chain (Tubulin beta class V) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-190840 | 0.000227925590883 | 1.0 | TUBA1C TUBB6 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 0.000256416289743 | 1.0 | TUBA1C TUBB6 | Transport of connexons to the plasma membrane |
| REAC:R-HSA-389977 | 0.000351943927099 | 1.0 | TUBA1C TUBB6 | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-190861 | 0.000424008635981 | 1.0 | TUBA1C TUBB6 | Gap junction assembly |
| REAC:R-HSA-9619483 | 0.000462554875615 | 1.0 | TUBA1C TUBB6 | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 0.000462554875615 | 1.0 | TUBA1C TUBB6 | Formation of tubulin folding intermediates by CCT/TriC |
| WP:WP2272 | 0.000494042845858 | 1.0 | TUBA1C TUBB6 | Pathogenic Escherichia coli infection |
| KEGG:04540 | 0.000508598838856 | 1.0 | TUBA1C TUBB6 | Gap junction |
| REAC:R-HSA-389957 | 0.000588249135293 | 1.0 | TUBA1C TUBB6 | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-5626467 | 0.000633499068778 | 1.0 | TUBA1C TUBB6 | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 0.000779304410004 | 1.0 | TUBA1C TUBB6 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| WP:WP2359 | 0.000799186956535 | 1.0 | TUBA1C TUBB6 | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-190828 | 0.000940193062392 | 1.0 | TUBA1C TUBB6 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.000997174460113 | 1.0 | TUBA1C TUBB6 | Gap junction trafficking and regulation |
| REAC:R-HSA-8955332 | 0.00111616502594 | 1.0 | TUBA1C TUBB6 | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 0.00117817419405 | 1.0 | TUBA1C TUBB6 | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04145 | 0.00131964328671 | 1.0 | TUBA1C TUBB6 | Phagosome |
| REAC:R-HSA-437239 | 0.00165916422775 | 1.0 | TUBA1C TUBB6 | Recycling pathway of L1 |
| REAC:R-HSA-6811436 | 0.00205300624141 | 1.0 | TUBA1C TUBB6 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-5620924 | 0.00213680241453 | 1.0 | TUBA1C TUBB6 | Intraflagellar transport |
| REAC:R-HSA-3371497 | 0.00222227451111 | 1.0 | TUBA1C TUBB6 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| KEGG:05130 | 0.00227250014745 | 1.0 | TUBA1C TUBB6 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-983189 | 0.00267477384595 | 1.0 | TUBA1C TUBB6 | Kinesins |
| REAC:R-HSA-1445148 | 0.00381775364729 | 1.0 | TUBA1C TUBB6 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-438064 | 0.00440432685912 | 1.0 | TUBA1C TUBB6 | Post NMDA receptor activation events |
| REAC:R-HSA-8852276 | 0.00477638186777 | 1.0 | TUBA1C TUBB6 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-442755 | 0.00584226918984 | 1.0 | TUBA1C TUBB6 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-390466 | 0.00671207346681 | 1.0 | TUBA1C TUBB6 | Chaperonin-mediated protein folding |
| REAC:R-HSA-380320 | 0.00671207346681 | 1.0 | TUBA1C TUBB6 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-391251 | 0.00764221098843 | 1.0 | TUBA1C TUBB6 | Protein folding |
| REAC:R-HSA-6811434 | 0.00764221098843 | 1.0 | TUBA1C TUBB6 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 0.00780309964082 | 1.0 | TUBA1C TUBB6 | COPI-mediated anterograde transport |
| REAC:R-HSA-373760 | 0.0102315127378 | 1.0 | TUBA1C TUBB6 | L1CAM interactions |
| REAC:R-HSA-5610787 | 0.0102315127378 | 1.0 | TUBA1C TUBB6 | Hedgehog 'off' state |
| REAC:R-HSA-2132295 | 0.011178409494 | 1.0 | TUBA1C TUBB6 | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 0.0119660935214 | 1.0 | TUBA1C TUBB6 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.014052618232 | 1.0 | TUBA1C TUBB6 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.0147112561527 | 1.0 | TUBA1C TUBB6 | RHO GTPases Activate Formins |
| REAC:R-HSA-5358351 | 0.0167776697818 | 1.0 | TUBA1C TUBB6 | Signaling by Hedgehog |
| REAC:R-HSA-199977 | 0.0172553079686 | 1.0 | TUBA1C TUBB6 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-983231 | 0.0210512746109 | 1.0 | TUBA1C TUBB6 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-948021 | 0.0237914094719 | 1.0 | TUBA1C TUBB6 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-112314 | 0.0255159347147 | 1.0 | TUBA1C TUBB6 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2467813 | 0.0279091534189 | 1.0 | TUBA1C TUBB6 | Separation of Sister Chromatids |
| REAC:R-HSA-69275 | 0.0300912057669 | 1.0 | TUBA1C TUBB6 | G2/M Transition |
| REAC:R-HSA-68877 | 0.0304096312248 | 1.0 | TUBA1C TUBB6 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.0304096312248 | 1.0 | TUBA1C TUBB6 | Mitotic Anaphase |
| REAC:R-HSA-5617833 | 0.0304096312248 | 1.0 | TUBA1C TUBB6 | Cilium Assembly |
| REAC:R-HSA-2555396 | 0.0307297326061 | 1.0 | TUBA1C TUBB6 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 0.0307297326061 | 1.0 | TUBA1C TUBB6 | Mitotic G2-G2/M phases |
| REAC:R-HSA-6811442 | 0.0323553783646 | 1.0 | TUBA1C TUBB6 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-112315 | 0.0429891127334 | 1.0 | TUBA1C TUBB6 | Transmission across Chemical Synapses |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBA1C | TUBB6 | 0.729 | 0.735 | hein_WMM bioplex (TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_00284 has an average edge precision of 0.735 which is ranked 1235 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TUBA1C | HuMAP2_00105 HuMAP2_00284 HuMAP2_01876 HuMAP2_02619 HuMAP2_02732 HuMAP2_05358 |
| TUBB6 | HuMAP2_00284 HuMAP2_00602 HuMAP2_01876 HuMAP2_02732 HuMAP2_05358 HuMAP2_06702 |