hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00288
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 1.57358918852e-08 | 1.0 | AGO1 AGO3 AGO2 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 2.51774270163e-08 | 1.0 | AGO1 AGO3 AGO2 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-8943723 | 3.77661405245e-08 | 1.0 | AGO1 AGO3 AGO2 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-426486 | 3.77661405245e-08 | 1.0 | AGO1 AGO3 AGO2 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-8934593 | 3.05725899484e-07 | 1.0 | AGO1 AGO3 AGO2 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-203927 | 9.09984147875e-07 | 1.0 | AGO1 AGO3 AGO2 | MicroRNA (miRNA) biogenesis |
| REAC:R-HSA-9022692 | 1.64282711281e-06 | 1.0 | AGO1 AGO3 AGO2 | Regulation of MECP2 expression and activity |
| GO:0035280 | 3.17865016081e-06 | 1.0 | AGO1 AGO3 AGO2 | miRNA loading onto RISC involved in gene silencing by miRNA |
| GO:0010501 | 5.08584025729e-06 | 1.0 | AGO1 AGO3 AGO2 | RNA secondary structure unwinding |
| GO:0070922 | 7.62876038594e-06 | 1.0 | AGO1 AGO3 AGO2 | small RNA loading onto RISC |
| GO:0070578 | 7.62876038594e-06 | 1.0 | AGO1 AGO3 AGO2 | RISC-loading complex |
| REAC:R-HSA-4086398 | 1.05322572372e-05 | 1.0 | AGO1 AGO3 AGO2 | Ca2+ pathway |
| REAC:R-HSA-8986944 | 1.05322572372e-05 | 1.0 | AGO1 AGO3 AGO2 | Transcriptional Regulation by MECP2 |
| GO:0045974 | 2.59741127426e-05 | 1.0 | AGO1 AGO3 AGO2 | regulation of translation, ncRNA-mediated |
| GO:0035278 | 2.59741127426e-05 | 1.0 | AGO1 AGO3 AGO2 | miRNA mediated inhibition of translation |
| GO:0040033 | 2.59741127426e-05 | 1.0 | AGO1 AGO3 AGO2 | negative regulation of translation, ncRNA-mediated |
| GO:0016442 | 2.59741127426e-05 | 1.0 | AGO1 AGO3 AGO2 | RISC complex |
| GO:0031332 | 2.59741127426e-05 | 1.0 | AGO1 AGO3 AGO2 | RNAi effector complex |
| REAC:R-HSA-5628897 | 3.69388822082e-05 | 1.0 | AGO1 AGO3 AGO2 | TP53 Regulates Metabolic Genes |
| GO:0031054 | 4.13224520905e-05 | 1.0 | AGO1 AGO3 AGO2 | pre-miRNA processing |
| REAC:R-HSA-5687128 | 4.7655024582e-05 | 1.0 | AGO1 AGO3 AGO2 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912408 | 5.46192807335e-05 | 1.0 | AGO1 AGO3 AGO2 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-1912422 | 8.92382428809e-05 | 1.0 | AGO1 AGO3 AGO2 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-211000 | 0.000168445978677 | 1.0 | AGO1 AGO3 AGO2 | Gene Silencing by RNA |
| REAC:R-HSA-6807070 | 0.000180286113329 | 1.0 | AGO1 AGO3 AGO2 | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.000188480017032 | 1.0 | AGO1 AGO3 AGO2 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-9018519 | 0.000205605163372 | 1.0 | AGO1 AGO3 AGO2 | Estrogen-dependent gene expression |
| GO:1902555 | 0.000297521655052 | 1.0 | AGO1 AGO3 AGO2 | endoribonuclease complex |
| GO:0035198 | 0.000297521655052 | 1.0 | AGO1 AGO3 AGO2 | miRNA binding |
| MIRNA:hsa-miR-652-3p | 0.000388893275538 | 1.0 | AGO1 AGO3 AGO2 | hsa-miR-652-3p |
| GO:0007223 | 0.000495506150782 | 1.0 | AGO1 AGO3 AGO2 | Wnt signaling pathway, calcium modulating pathway |
| GO:1905348 | 0.000495506150782 | 1.0 | AGO1 AGO3 AGO2 | endonuclease complex |
| GO:0061980 | 0.000594407580071 | 1.0 | AGO1 AGO3 AGO2 | regulatory RNA binding |
| REAC:R-HSA-8939211 | 0.000626829811712 | 1.0 | AGO1 AGO3 AGO2 | ESR-mediated signaling |
| REAC:R-HSA-8878171 | 0.000776305048729 | 1.0 | AGO1 AGO3 AGO2 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 0.000787037376592 | 1.0 | AGO1 AGO3 AGO2 | Signaling by NOTCH |
| REAC:R-HSA-1257604 | 0.000842184933696 | 1.0 | AGO1 AGO3 AGO2 | PIP3 activates AKT signaling |
| REAC:R-HSA-5683057 | 0.00097245114269 | 1.0 | AGO1 AGO3 AGO2 | MAPK family signaling cascades |
| GO:0035196 | 0.00104259725275 | 1.0 | AGO1 AGO3 AGO2 | production of miRNAs involved in gene silencing by miRNA |
| REAC:R-HSA-9006931 | 0.00107518583524 | 1.0 | AGO1 AGO3 AGO2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-9006925 | 0.00134762672661 | 1.0 | AGO1 AGO3 AGO2 | Intracellular signaling by second messengers |
| GO:0090624 | 0.00135247023414 | 0.666666666667 | AGO2 AGO3 | endoribonuclease activity, cleaving miRNA-paired mRNA |
| GO:0070918 | 0.00137862598403 | 1.0 | AGO1 AGO3 AGO2 | production of small RNA involved in gene silencing by RNA |
| GO:0031050 | 0.00137862598403 | 1.0 | AGO1 AGO3 AGO2 | dsRNA processing |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | AGO1 AGO3 AGO2 | Signaling by WNT |
| MIRNA:hsa-miR-107 | 0.00240077956866 | 1.0 | AGO1 AGO3 AGO2 | hsa-miR-107 |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | AGO1 AGO3 AGO2 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-2559585 | 0.0033164570092 | 0.666666666667 | AGO1 AGO3 | Oncogene Induced Senescence |
| GO:0003725 | 0.00360649647245 | 1.0 | AGO1 AGO3 AGO2 | double-stranded RNA binding |
| GO:0003727 | 0.00378386515143 | 1.0 | AGO1 AGO3 AGO2 | single-stranded RNA binding |
| MIRNA:hsa-miR-148b-3p | 0.00424667661484 | 1.0 | AGO1 AGO3 AGO2 | hsa-miR-148b-3p |
| MIRNA:hsa-miR-103a-3p | 0.00842873649059 | 1.0 | AGO1 AGO3 AGO2 | hsa-miR-103a-3p |
| GO:0017148 | 0.0160613559883 | 1.0 | AGO1 AGO3 AGO2 | negative regulation of translation |
| GO:0034249 | 0.022423560513 | 1.0 | AGO1 AGO3 AGO2 | negative regulation of cellular amide metabolic process |
| MIRNA:hsa-miR-382-3p | 0.0264402587388 | 0.666666666667 | AGO2 AGO3 | hsa-miR-382-3p |
| REAC:R-HSA-8936459 | 0.0279140119136 | 0.666666666667 | AGO1 AGO3 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| MIRNA:hsa-miR-2115-5p | 0.0325858677372 | 0.666666666667 | AGO2 AGO3 | hsa-miR-2115-5p |
| GO:0035567 | 0.033252767518 | 1.0 | AGO1 AGO3 AGO2 | non-canonical Wnt signaling pathway |
| MIRNA:hsa-miR-7162-5p | 0.0333990138909 | 0.666666666667 | AGO2 AGO3 | hsa-miR-7162-5p |
| MIRNA:hsa-miR-516b-3p | 0.0333990138909 | 0.666666666667 | AGO2 AGO3 | hsa-miR-516b-3p |
| REAC:R-HSA-5578749 | 0.0343335993912 | 0.666666666667 | AGO1 AGO2 | Transcriptional regulation by small RNAs |
| MIRNA:hsa-miR-516a-3p | 0.0350552546403 | 0.666666666667 | AGO2 AGO3 | hsa-miR-516a-3p |
| MIRNA:hsa-miR-6811-5p | 0.0393704925026 | 0.666666666667 | AGO2 AGO3 | hsa-miR-6811-5p |
| GO:0035195 | 0.0397775372938 | 1.0 | AGO1 AGO3 AGO2 | gene silencing by miRNA |
| MIRNA:hsa-miR-6511b-5p | 0.0402634668291 | 0.666666666667 | AGO2 AGO3 | hsa-miR-6511b-5p |
| WP:WP2805 | 0.0428416541517 | 0.333333333333 | AGO2 | exRNA mechanism of action and biogenesis |
| MIRNA:hsa-miR-3616-3p | 0.0430022189176 | 0.666666666667 | AGO1 AGO2 | hsa-miR-3616-3p |
| GO:0035194 | 0.0480789908723 | 1.0 | AGO1 AGO3 AGO2 | posttranscriptional gene silencing by RNA |
| GO:0016441 | 0.0490669153423 | 1.0 | AGO1 AGO3 AGO2 | posttranscriptional gene silencing |
| REAC:R-HSA-2559580 | 0.0491532487396 | 0.666666666667 | AGO1 AGO3 | Oxidative Stress Induced Senescence |
| CORUM:5360 | 0.0499776345577 | 0.333333333333 | AGO2 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
| CORUM:1387 | 0.0499776345577 | 0.333333333333 | AGO2 | TTP-AGO2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AGO1 | AGO2 | 0.822 | 0.774 | youn (AGO2) bioplex_WMM youn_WMM treiber_WMM |
| AGO3 | AGO2 | 0.797 | 0.764 | youn (AGO2) bioplex_WMM youn_WMM treiber_WMM |
| AGO1 | AGO3 | 0.013 | 0.149 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_00288 has an average edge precision of 0.562 which is ranked 2119 out of all 6965 complexes.
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