hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00292
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DPYSL3 | Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1) | UniProt NCBI |
| DPYSL5 | Dihydropyrimidinase-related protein 5 (DRP-5) (CRMP3-associated molecule) (CRAM) (Collapsin response mediator protein 5) (CRMP-5) (UNC33-like phosphoprotein 6) (ULIP-6) | UniProt NCBI |
| DPYSL2 | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2) | UniProt NCBI |
| CRMP1 | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Unc-33-like phosphoprotein 3) (ULIP-3) | UniProt NCBI |
| DPYSL4 | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | UniProt NCBI |
| GGACT | Gamma-glutamylaminecyclotransferase (GGACT) (EC 4.3.2.8) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase) | UniProt NCBI |
| UBE2C | Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) | UniProt NCBI |
| HMGCS1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase) | UniProt NCBI |
| CNTN1 | Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3) | UniProt NCBI |
| PPIL3 | Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) | UniProt NCBI |
| BLMH | Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-399956 | 7.22388695951e-11 | 0.454545454545 | DPYSL5 CRMP1 DPYSL4 DPYSL2 DPYSL3 | CRMPs in Sema3A signaling |
| GO:0016812 | 4.76228219893e-10 | 0.454545454545 | DPYSL5 CRMP1 DPYSL4 DPYSL2 DPYSL3 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| REAC:R-HSA-373755 | 8.16076088605e-08 | 0.454545454545 | DPYSL5 CRMP1 DPYSL4 DPYSL2 DPYSL3 | Semaphorin interactions |
| REAC:R-HSA-422475 | 0.00014182526667 | 0.545454545455 | DPYSL5 CRMP1 DPYSL3 DPYSL2 CNTN1 DPYSL4 | Axon guidance |
| GO:0016810 | 0.000262260204552 | 0.454545454545 | DPYSL5 CRMP1 DPYSL4 DPYSL2 DPYSL3 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| GO:0031005 | 0.00179314168727 | 0.272727272727 | DPYSL3 CRMP1 DPYSL4 | filamin binding |
| REAC:R-HSA-1266738 | 0.00425864350456 | 0.545454545455 | DPYSL5 CRMP1 DPYSL3 DPYSL2 CNTN1 DPYSL4 | Developmental Biology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DPYSL3 | DPYSL2 | 0.963 | 0.87 | bioplex (DPYSL3) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| DPYSL5 | DPYSL2 | 0.936 | 0.85 | bioplex (DPYSL5) bioplex_WMM youn_WMM gupta_WMM fraction |
| DPYSL3 | CRMP1 | 0.922 | 0.843 | bioplex (DPYSL3) bioplex_WMM youn_WMM gupta_WMM fraction |
| DPYSL5 | DPYSL4 | 0.831 | 0.778 | bioplex (DPYSL5) bioplex_WMM youn_WMM gupta_WMM |
| BLMH | DPYSL2 | 0.408 | 0.567 | fraction treiber_WMM |
| DPYSL5 | DPYSL3 | 0.249 | 0.472 | bioplex (DPYSL3,DPYSL5) bioplex_WMM youn_WMM gupta_WMM |
| BLMH | DPYSL3 | 0.224 | 0.466 | fraction treiber_WMM |
| BLMH | CRMP1 | 0.215 | 0.464 | fraction |
| DPYSL3 | DPYSL4 | 0.214 | 0.464 | bioplex (DPYSL3) bioplex_WMM youn_WMM gupta_WMM |
| BLMH | DPYSL5 | 0.093 | 0.355 | fraction |
| BLMH | DPYSL4 | 0.072 | 0.353 | fraction |
| PPIL3 | DPYSL2 | 0.068 | 0.35 | bioplex_WMM youn_WMM gupta_WMM fraction |
| DPYSL3 | HMGCS1 | 0.066 | 0.347 | fraction |
| DPYSL2 | HMGCS1 | 0.059 | 0.328 | fraction bioplex_WMM |
| GGACT | DPYSL2 | 0.052 | 0.299 | fraction |
| PPIL3 | UBE2C | 0.05 | 0.298 | fraction |
| GGACT | UBE2C | 0.049 | 0.293 | fraction |
| CNTN1 | DPYSL3 | 0.049 | 0.296 | bioplex_WMM fraction |
| PPIL3 | DPYSL5 | 0.047 | 0.294 | bioplex_WMM youn_WMM gupta_WMM fraction |
| GGACT | DPYSL3 | 0.044 | 0.28 | fraction |
| CNTN1 | DPYSL2 | 0.044 | 0.278 | bioplex_WMM fraction |
| PPIL3 | GGACT | 0.027 | 0.232 | fraction |
| UBE2C | DPYSL2 | 0.024 | 0.213 | fraction |
| UBE2C | DPYSL4 | 0.016 | 0.156 | fraction |
| DPYSL5 | CRMP1 | 0.015 | 0.149 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DPYSL5 | GGACT | 0.013 | 0.151 | fraction |
| PPIL3 | DPYSL4 | 0.012 | 0.147 | youn_WMM gupta_WMM fraction |
| CNTN1 | CRMP1 | 0.011 | 0.144 | bioplex_WMM WMM_only |
| BLMH | UBE2C | 0.01 | 0.141 | fraction |
| DPYSL2 | DPYSL4 | 0.01 | 0.126 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CRMP1 | DPYSL4 | 0.009 | 0.112 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DPYSL5 | CNTN1 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| DPYSL2 | CRMP1 | 0.008 | 0.085 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CNTN1 | DPYSL4 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| DPYSL5 | HMGCS1 | 0.007 | 0.009 | fraction bioplex_WMM |
| PPIL3 | DPYSL3 | 0.007 | 0.007 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PPIL3 | CNTN1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PPIL3 | CRMP1 | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| PPIL3 | HMGCS1 | 0.006 | 0.007 | bioplex_WMM fraction |
| UBE2C | DPYSL3 | 0.006 | 0.003 | fraction |
| BLMH | GGACT | 0.005 | 0.011 | fraction |
| DPYSL5 | UBE2C | 0.004 | 0.011 | fraction |
| BLMH | PPIL3 | 0.004 | 0.01 | hein_WMM bioplex (BLMH) bioplex_WMM fraction |
| HMGCS1 | DPYSL4 | 0.004 | 0.012 | fraction |
| CNTN1 | UBE2C | 0.003 | 0.013 | fraction |
| BLMH | CNTN1 | 0.0 | 0.01 | fraction |
| GGACT | HMGCS1 | 0.0 | 0.013 | fraction |
| UBE2C | HMGCS1 | 0.0 | 0.002 | fraction |
Images
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Complex HuMAP2_00292 has an average edge precision of 0.239 which is ranked 5547 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DPYSL3 | HuMAP2_00292 HuMAP2_02427 HuMAP2_05645 HuMAP2_06701 |
| DPYSL5 | HuMAP2_00292 HuMAP2_02285 HuMAP2_02427 HuMAP2_03430 |
| DPYSL2 | HuMAP2_00292 HuMAP2_02285 |
| CRMP1 | HuMAP2_00292 HuMAP2_05645 HuMAP2_06701 |
| DPYSL4 | HuMAP2_00292 HuMAP2_02427 HuMAP2_03430 |
| GGACT | HuMAP2_00292 HuMAP2_00317 |
| UBE2C | HuMAP2_00292 HuMAP2_00317 HuMAP2_02285 HuMAP2_02626 HuMAP2_05954 |
| HMGCS1 | HuMAP2_00292 HuMAP2_01959 HuMAP2_04726 HuMAP2_05645 |
| CNTN1 | HuMAP2_00292 HuMAP2_05645 |
| PPIL3 | HuMAP2_00174 HuMAP2_00292 HuMAP2_00317 HuMAP2_02285 HuMAP2_02690 HuMAP2_05912 |
| BLMH | HuMAP2_00098 HuMAP2_00292 HuMAP2_00869 HuMAP2_06220 |