hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00294
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RUVBL2 | RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta) | UniProt NCBI |
| INO80B | INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) | UniProt NCBI |
| UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) | UniProt NCBI |
| INO80 | Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A) | UniProt NCBI |
| ACTR8 | Actin-related protein 8 (hArp8) (INO80 complex subunit N) | UniProt NCBI |
| INO80C | INO80 complex subunit C (IES6 homolog) (hIes6) | UniProt NCBI |
| TFPT | TCF3 fusion partner (INO80 complex subunit F) (Protein FB1) | UniProt NCBI |
| NFRKB | Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) (INO80 complex subunit G) | UniProt NCBI |
| WBP2NL | Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like) | UniProt NCBI |
| ACTR5 | Actin-related protein 5 (hARP5) (Sarcoma antigen NY-SAR-16) | UniProt NCBI |
| YY1 | Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) | UniProt NCBI |
| INO80E | INO80 complex subunit E (Coiled-coil domain-containing protein 95) | UniProt NCBI |
| INO80D | INO80 complex subunit D | UniProt NCBI |
| DPCD | Protein DPCD | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031011 | 1.24313413215e-28 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | Ino80 complex |
| GO:0033202 | 1.24313413215e-28 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | DNA helicase complex |
| GO:0097346 | 4.05194921702e-25 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | INO80-type complex |
| CORUM:302 | 7.67004254012e-25 | 0.642857142857 | ACTR8 INO80 RUVBL2 INO80C INO80B INO80D ACTR5 NFRKB INO80E | INO80 chromatin remodeling complex |
| REAC:R-HSA-5696394 | 8.08244532255e-22 | 0.714285714286 | TFPT INO80 ACTR8 INO80C INO80B INO80D ACTR5 INO80E NFRKB YY1 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-5689603 | 6.44515036975e-20 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | UCH proteinases |
| GO:0070603 | 6.01568756755e-19 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | SWI/SNF superfamily-type complex |
| GO:1904949 | 9.42806138968e-19 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | ATPase complex |
| REAC:R-HSA-5696399 | 4.66767413937e-18 | 0.714285714286 | TFPT INO80 ACTR8 INO80C INO80B INO80D ACTR5 INO80E NFRKB YY1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 7.87784950581e-17 | 0.714285714286 | TFPT INO80 ACTR8 INO80C INO80B INO80D ACTR5 INO80E NFRKB YY1 | Nucleotide Excision Repair |
| REAC:R-HSA-5688426 | 4.22819581727e-15 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | Deubiquitination |
| GO:0016579 | 3.32311989336e-13 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | protein deubiquitination |
| GO:0070646 | 6.73921058163e-13 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | protein modification by small protein removal |
| REAC:R-HSA-73894 | 4.42980235911e-12 | 0.714285714286 | TFPT INO80 ACTR8 INO80C INO80B INO80D ACTR5 INO80E NFRKB YY1 | DNA Repair |
| GO:0000790 | 9.1337007995e-08 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | nuclear chromatin |
| REAC:R-HSA-597592 | 1.09949383943e-07 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | Post-translational protein modification |
| GO:0070647 | 1.85449669787e-07 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | protein modification by small protein conjugation or removal |
| GO:0000785 | 5.55540532909e-07 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | chromatin |
| GO:0044454 | 7.94371005072e-07 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | nuclear chromosome part |
| GO:0000228 | 1.06064888053e-06 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | nuclear chromosome |
| REAC:R-HSA-392499 | 5.36902041936e-06 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | Metabolism of proteins |
| GO:1902494 | 1.23295189921e-05 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | catalytic complex |
| GO:0044427 | 1.58353390178e-05 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | chromosomal part |
| GO:0006508 | 1.66948733294e-05 | 0.785714285714 | TFPT INO80 ACTR8 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | proteolysis |
| GO:0005694 | 2.33906101643e-05 | 0.785714285714 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B YY1 ACTR5 NFRKB INO80E | chromosome |
| CORUM:0000000 | 0.0084907099444 | 0.714285714286 | ACTR8 INO80 RUVBL2 INO80C INO80B INO80D ACTR5 INO80E NFRKB YY1 | CORUM root |
| GO:0006338 | 0.0093208273089 | 0.357142857143 | ACTR8 RUVBL2 ACTR5 INO80 INO80C | chromatin remodeling |
| GO:0006464 | 0.0102322724519 | 0.857142857143 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | cellular protein modification process |
| GO:0036211 | 0.0102322724519 | 0.857142857143 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | protein modification process |
| GO:0034644 | 0.0150230460354 | 0.285714285714 | RUVBL2 YY1 INO80 ACTR5 | cellular response to UV |
| GO:0043412 | 0.0199188651959 | 0.857142857143 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | macromolecule modification |
| GO:0005654 | 0.0267056216714 | 0.857142857143 | ACTR8 TFPT INO80 RUVBL2 INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | nucleoplasm |
| GO:0005634 | 0.0414378012246 | 1.0 | ACTR8 TFPT INO80 DPCD RUVBL2 WBP2NL INO80C UCHL5 INO80B INO80D ACTR5 INO80E NFRKB YY1 | nucleus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACTR5 | INO80E | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| NFRKB | ACTR5 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (ACTR5) Malo fraction |
| INO80 | INO80E | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | INO80E | 0.998 | 0.944 | hein_WMM bioplex_WMM Malo fraction |
| NFRKB | ACTR8 | 0.998 | 0.944 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| INO80 | NFRKB | 0.997 | 0.93 | hein_WMM bioplex_WMM Malo fraction |
| RUVBL2 | DPCD | 0.995 | 0.923 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM boldt_WMM |
| RUVBL2 | INO80 | 0.987 | 0.901 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| UCHL5 | INO80E | 0.919 | 0.841 | bioplex (UCHL5) bioplex_WMM |
| INO80B | RUVBL2 | 0.851 | 0.791 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM |
| UCHL5 | INO80 | 0.85 | 0.79 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | NFRKB | 0.848 | 0.79 | bioplex (UCHL5) bioplex_WMM |
| RUVBL2 | INO80D | 0.831 | 0.778 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| RUVBL2 | INO80C | 0.728 | 0.735 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| RUVBL2 | ACTR5 | 0.702 | 0.723 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (ACTR5,RUVBL2) boldt_WMM |
| RUVBL2 | NFRKB | 0.604 | 0.672 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM boldt_WMM |
| RUVBL2 | INO80E | 0.462 | 0.6 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| UCHL5 | TFPT | 0.343 | 0.533 | bioplex (UCHL5) bioplex_WMM |
| INO80C | ACTR5 | 0.337 | 0.527 | hein_WMM bioplex_WMM hein (ACTR5) |
| UCHL5 | ACTR5 | 0.317 | 0.509 | bioplex (UCHL5) bioplex_WMM |
| INO80B | UCHL5 | 0.316 | 0.51 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | ACTR8 | 0.299 | 0.497 | bioplex (UCHL5) bioplex_WMM |
| UCHL5 | INO80C | 0.261 | 0.482 | bioplex (UCHL5) bioplex_WMM |
| RUVBL2 | TFPT | 0.243 | 0.468 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) |
| TFPT | ACTR5 | 0.229 | 0.468 | hein_WMM bioplex_WMM hein (ACTR5) |
| RUVBL2 | YY1 | 0.139 | 0.407 | hein_WMM bioplex (RUVBL2) bioplex_WMM hein (RUVBL2) gupta_WMM |
| ACTR5 | ACTR8 | 0.076 | 0.358 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80D | ACTR5 | 0.074 | 0.356 | hein_WMM bioplex_WMM hein (ACTR5) |
| RUVBL2 | ACTR8 | 0.034 | 0.263 | hein_WMM bioplex (ACTR8,RUVBL2) bioplex_WMM hein (RUVBL2) |
| TFPT | INO80E | 0.033 | 0.252 | hein_WMM bioplex_WMM WMM_only |
| INO80C | WBP2NL | 0.031 | 0.241 | bioplex (WBP2NL) bioplex_WMM |
| WBP2NL | ACTR5 | 0.028 | 0.231 | bioplex (WBP2NL) bioplex_WMM |
| INO80C | INO80E | 0.024 | 0.214 | hein_WMM bioplex_WMM WMM_only |
| INO80 | INO80C | 0.023 | 0.206 | hein_WMM bioplex_WMM WMM_only |
| INO80B | ACTR5 | 0.023 | 0.211 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80C | ACTR8 | 0.022 | 0.205 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80C | 0.022 | 0.196 | hein_WMM bioplex_WMM WMM_only |
| INO80D | UCHL5 | 0.021 | 0.188 | bioplex (UCHL5) bioplex_WMM |
| ACTR8 | INO80E | 0.021 | 0.184 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80E | 0.02 | 0.185 | hein_WMM bioplex_WMM WMM_only |
| ACTR5 | YY1 | 0.02 | 0.188 | hein_WMM bioplex_WMM hein (ACTR5) |
| INO80 | ACTR8 | 0.02 | 0.187 | hein_WMM bioplex_WMM WMM_only |
| INO80B | TFPT | 0.02 | 0.188 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80 | 0.019 | 0.183 | hein_WMM bioplex_WMM WMM_only |
| INO80C | TFPT | 0.018 | 0.18 | hein_WMM bioplex_WMM WMM_only |
| INO80B | ACTR8 | 0.018 | 0.182 | hein_WMM bioplex_WMM WMM_only |
| INO80B | INO80D | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80C | 0.018 | 0.177 | hein_WMM bioplex_WMM WMM_only |
| TFPT | NFRKB | 0.018 | 0.176 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80E | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| INO80B | NFRKB | 0.017 | 0.173 | hein_WMM bioplex_WMM WMM_only |
| INO80D | TFPT | 0.017 | 0.17 | hein_WMM bioplex_WMM WMM_only |
| INO80 | TFPT | 0.016 | 0.159 | hein_WMM bioplex_WMM WMM_only |
| INO80C | NFRKB | 0.016 | 0.161 | hein_WMM bioplex_WMM WMM_only |
| TFPT | ACTR8 | 0.016 | 0.155 | hein_WMM bioplex_WMM WMM_only |
| INO80D | YY1 | 0.016 | 0.155 | hein_WMM bioplex_WMM WMM_only |
| INO80D | NFRKB | 0.015 | 0.151 | hein_WMM bioplex_WMM WMM_only |
| INO80D | INO80 | 0.015 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| INO80D | ACTR8 | 0.015 | 0.143 | hein_WMM bioplex_WMM WMM_only |
| INO80B | YY1 | 0.015 | 0.14 | hein_WMM bioplex_WMM WMM_only |
| INO80C | YY1 | 0.014 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| YY1 | INO80E | 0.014 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| UCHL5 | YY1 | 0.013 | 0.144 | bioplex (UCHL5) bioplex_WMM |
| TFPT | YY1 | 0.013 | 0.141 | hein_WMM bioplex_WMM WMM_only |
| INO80D | DPCD | 0.013 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| NFRKB | YY1 | 0.013 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ACTR8 | YY1 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| INO80 | YY1 | 0.012 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| DPCD | ACTR5 | 0.012 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| INO80B | DPCD | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| INO80C | DPCD | 0.012 | 0.149 | hein_WMM bioplex_WMM WMM_only |
| DPCD | INO80E | 0.011 | 0.148 | hein_WMM bioplex_WMM WMM_only |
| TFPT | DPCD | 0.011 | 0.143 | hein_WMM bioplex_WMM WMM_only |
| DPCD | YY1 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NFRKB | DPCD | 0.011 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| INO80 | DPCD | 0.011 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| DPCD | ACTR8 | 0.011 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| RUVBL2 | UCHL5 | 0.01 | 0.129 | bioplex (RUVBL2,UCHL5) bioplex_WMM Guru fraction |
| UCHL5 | DPCD | 0.008 | 0.084 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00294 has an average edge precision of 0.361 which is ranked 3743 out of all 6965 complexes.
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