hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00297
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERLIN1 | Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1) | UniProt NCBI |
| ERLIN2 | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | UniProt NCBI |
| FKBP14 | Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (22 kDa FK506-binding protein) (22 kDa FKBP) (FKBP-22) (FK506-binding protein 14) (FKBP-14) (Rotamase) | UniProt NCBI |
| RIC3 | Protein RIC-3 (Resistant to inhibitor of cholinesterase 3) | UniProt NCBI |
| RNF170 | E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6476 | 1.35146690511e-09 | 0.6 | ERLIN2 RNF170 ERLIN1 | erlin1/2-RNF170 complex |
| HP:0003487 | 0.0111739705033 | 0.6 | ERLIN2 RNF170 ERLIN1 | Babinski sign |
| HP:0031828 | 0.0111739705033 | 0.6 | ERLIN2 RNF170 ERLIN1 | Abnormal superficial reflex |
| REAC:R-HSA-5678895 | 0.0237053784759 | 0.4 | ERLIN2 ERLIN1 | Defective CFTR causes cystic fibrosis |
| REAC:R-HSA-5619084 | 0.0380875604325 | 0.4 | ERLIN2 ERLIN1 | ABC transporter disorders |
| HP:0007256 | 0.0404739521804 | 0.6 | ERLIN2 RNF170 ERLIN1 | Abnormal pyramidal sign |
| GO:0045541 | 0.0450641792523 | 0.4 | ERLIN2 ERLIN1 | negative regulation of cholesterol biosynthetic process |
| GO:0090206 | 0.0450641792523 | 0.4 | ERLIN2 ERLIN1 | negative regulation of cholesterol metabolic process |
| GO:0106119 | 0.0450641792523 | 0.4 | ERLIN2 ERLIN1 | negative regulation of sterol biosynthetic process |
| HP:0004302 | 0.0459250116542 | 0.6 | ERLIN2 ERLIN1 FKBP14 | Functional motor deficit |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERLIN1 | ERLIN2 | 0.53 | 0.635 | hein_WMM bioplex (ERLIN1,ERLIN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ERLIN2 | RIC3 | 0.159 | 0.416 | bioplex (RIC3) bioplex_WMM |
| RNF170 | ERLIN1 | 0.061 | 0.339 | bioplex (RNF170) bioplex_WMM |
| ERLIN2 | FKBP14 | 0.044 | 0.279 | bioplex (ERLIN2) bioplex_WMM gupta_WMM |
| RNF170 | ERLIN2 | 0.035 | 0.261 | bioplex (RNF170) bioplex_WMM |
| ERLIN1 | FKBP14 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00297 has an average edge precision of 0.322 which is ranked 4318 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ERLIN1 | HuMAP2_00297 HuMAP2_00520 HuMAP2_04947 HuMAP2_05246 |
| ERLIN2 | HuMAP2_00297 HuMAP2_00520 HuMAP2_04947 HuMAP2_05246 HuMAP2_05982 |
| FKBP14 | HuMAP2_00297 HuMAP2_02211 HuMAP2_02774 HuMAP2_05982 HuMAP2_06903 |
| RIC3 | HuMAP2_00297 HuMAP2_01061 HuMAP2_03081 HuMAP2_03991 HuMAP2_04721 HuMAP2_04947 HuMAP2_06329 HuMAP2_06798 |
| RNF170 | HuMAP2_00297 HuMAP2_04947 HuMAP2_05246 |