hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00310
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBM15 | RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15) | UniProt NCBI |
| VIRMA | Protein virilizer homolog | UniProt NCBI |
| CBLL1 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | UniProt NCBI |
| RBM15B | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | UniProt NCBI |
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14) | UniProt NCBI |
| CBLL2 | E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2) | UniProt NCBI |
| ZC3H13 | Zinc finger CCCH domain-containing protein 13 | UniProt NCBI |
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | UniProt NCBI |
| METTL3 | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 7.50686889053e-24 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 7.50686889053e-24 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | mRNA editing complex |
| GO:0001510 | 3.31155354568e-14 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | RNA methylation |
| GO:0080009 | 8.3158416118e-13 | 0.666666666667 | WTAP VIRMA ZC3H13 METTL3 CBLL1 METTL14 | mRNA methylation |
| GO:0034708 | 2.43239648597e-12 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | methyltransferase complex |
| GO:0016556 | 7.50684403408e-12 | 0.666666666667 | WTAP VIRMA ZC3H13 METTL3 CBLL1 METTL14 | mRNA modification |
| GO:0009451 | 9.99030573611e-12 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | RNA modification |
| GO:0043414 | 5.40806342262e-10 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | macromolecule methylation |
| GO:0032259 | 9.89950512583e-10 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | methylation |
| GO:0016607 | 1.76140781615e-06 | 0.777777777778 | WTAP RBM15 RBM15B ZC3H13 METTL3 VIRMA CBLL1 | nuclear speck |
| GO:1990234 | 9.77229542853e-06 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | transferase complex |
| GO:0016071 | 1.14514529971e-05 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | mRNA metabolic process |
| CORUM:929 | 4.84868808928e-05 | 0.333333333333 | VIRMA ZC3H13 WTAP | CEN complex |
| GO:1903311 | 0.000190424001245 | 0.666666666667 | WTAP RBM15 RBM15B METTL3 VIRMA METTL14 | regulation of mRNA metabolic process |
| GO:0016604 | 0.000302601535554 | 0.777777777778 | WTAP RBM15 RBM15B ZC3H13 METTL3 VIRMA CBLL1 | nuclear body |
| GO:1902494 | 0.000702677964338 | 0.888888888889 | WTAP RBM15 RBM15B ZC3H13 METTL14 VIRMA CBLL1 METTL3 | catalytic complex |
| GO:0006397 | 0.00137640098394 | 0.666666666667 | WTAP RBM15 RBM15B METTL3 VIRMA METTL14 | mRNA processing |
| GO:0009048 | 0.00217524004777 | 0.333333333333 | RBM15 RBM15B METTL3 | dosage compensation by inactivation of X chromosome |
| CORUM:351 | 0.00270716911675 | 0.333333333333 | RBM15 WTAP VIRMA | Spliceosome |
| GO:0007549 | 0.00345851718181 | 0.333333333333 | RBM15 RBM15B METTL3 | dosage compensation |
| GO:0044451 | 0.00537320209692 | 0.777777777778 | WTAP RBM15 RBM15B ZC3H13 METTL3 VIRMA CBLL1 | nucleoplasm part |
| GO:0000398 | 0.0229759062713 | 0.555555555556 | WTAP RBM15 METTL3 RBM15B METTL14 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.0229759062713 | 0.555555555556 | WTAP RBM15 METTL3 RBM15B METTL14 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.0240929466 | 0.555555555556 | WTAP RBM15 METTL3 RBM15B METTL14 | RNA splicing, via transesterification reactions |
| GO:0050684 | 0.0253033632406 | 0.444444444444 | WTAP RBM15 RBM15B VIRMA | regulation of mRNA processing |
| GO:0043412 | 0.0371716504333 | 1.0 | WTAP RBM15 RBM15B ZC3H13 CBLL2 METTL14 VIRMA CBLL1 METTL3 | macromolecule modification |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VIRMA | CBLL2 | 1.0 | 0.949 | bioplex (CBLL2) bioplex_WMM |
| VIRMA | CBLL1 | 0.993 | 0.918 | youn (VIRMA) youn_WMM Malo fraction |
| VIRMA | ZC3H13 | 0.988 | 0.902 | bioplex_WMM Guru youn_WMM Malo fraction |
| CBLL1 | WTAP | 0.976 | 0.889 | youn_WMM Malo fraction |
| CBLL2 | ZC3H13 | 0.96 | 0.865 | bioplex (CBLL2) bioplex_WMM |
| ZC3H13 | WTAP | 0.954 | 0.861 | bioplex_WMM Guru youn_WMM Malo fraction |
| VIRMA | WTAP | 0.921 | 0.843 | hein_WMM youn (VIRMA) bioplex_WMM Guru youn_WMM Malo fraction |
| CBLL2 | WTAP | 0.627 | 0.68 | bioplex (CBLL2) bioplex_WMM |
| WTAP | METTL3 | 0.324 | 0.513 | hein_WMM bioplex_WMM youn_WMM hein (METTL3) |
| RBM15B | METTL3 | 0.084 | 0.347 | hein_WMM youn_WMM hein (METTL3) |
| METTL14 | METTL3 | 0.05 | 0.294 | hein_WMM youn_WMM hein (METTL3) Malo fraction |
| RBM15 | RBM15B | 0.029 | 0.23 | bioplex (RBM15B) bioplex_WMM youn_WMM treiber_WMM |
| METTL14 | WTAP | 0.009 | 0.107 | hein_WMM youn_WMM WMM_only |
| RBM15B | ZC3H13 | 0.008 | 0.061 | hein_WMM bioplex_WMM WMM_only |
| VIRMA | RBM15B | 0.008 | 0.023 | bioplex_WMM youn_WMM WMM_only |
| CBLL1 | ZC3H13 | 0.008 | 0.023 | hein_WMM WMM_only |
| RBM15 | ZC3H13 | 0.008 | 0.014 | bioplex_WMM youn_WMM WMM_only |
| RBM15 | METTL3 | 0.008 | 0.012 | hein_WMM youn_WMM gupta_WMM WMM_only |
| RBM15B | WTAP | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| RBM15B | METTL14 | 0.007 | 0.008 | hein_WMM WMM_only |
| CBLL1 | METTL3 | 0.007 | 0.005 | youn_WMM WMM_only |
| METTL14 | CBLL1 | 0.007 | 0.009 | youn_WMM WMM_only |
| RBM15 | CBLL1 | 0.007 | 0.007 | youn_WMM WMM_only |
| RBM15 | METTL14 | 0.007 | 0.003 | youn_WMM WMM_only |
| RBM15B | CBLL1 | 0.007 | 0.002 | youn_WMM WMM_only |
| ZC3H13 | METTL3 | 0.007 | 0.001 | youn_WMM WMM_only |
| RBM15 | VIRMA | 0.007 | 0.004 | hein_WMM youn (VIRMA) bioplex_WMM youn_WMM |
| RBM15 | WTAP | 0.007 | 0.002 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| VIRMA | METTL3 | 0.006 | 0.002 | youn (VIRMA) youn_WMM |
| VIRMA | METTL14 | 0.005 | 0.009 | youn (VIRMA) youn_WMM |
Images
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Complex HuMAP2_00310 has an average edge precision of 0.286 which is ranked 4795 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RBM15 | HuMAP2_00310 HuMAP2_02097 |
| VIRMA | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| CBLL1 | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| RBM15B | HuMAP2_00310 HuMAP2_05045 HuMAP2_06148 |
| METTL14 | HuMAP2_00310 HuMAP2_05045 HuMAP2_06148 |
| CBLL2 | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| ZC3H13 | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| WTAP | HuMAP2_00310 HuMAP2_03946 HuMAP2_05045 HuMAP2_05108 |
| METTL3 | HuMAP2_00310 HuMAP2_05045 HuMAP2_06148 |