hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00315
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| H2AC11 | Histone H2A type 1 (H2A.1) (Histone H2A/ptl) | UniProt NCBI |
| HLTF | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | UniProt NCBI |
| APLF | Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | UniProt NCBI |
| BAD | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | UniProt NCBI |
| MSH3 | DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | UniProt NCBI |
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| CHD1L | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) (Amplified in liver cancer protein 1) | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | UniProt NCBI |
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | UniProt NCBI |
| RNF146 | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:362 | 1.49823856938e-11 | 0.333333333333 | XRCC1 LIG3 PNKP POLB | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| REAC:R-HSA-5649702 | 8.74306093602e-10 | 0.333333333333 | XRCC1 LIG3 PNKP POLB | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| REAC:R-HSA-73933 | 1.00559546934e-08 | 0.416666666667 | XRCC1 LIG3 PARP2 PNKP POLB | Resolution of Abasic Sites (AP sites) |
| CORUM:5243 | 9.91118107838e-08 | 0.25 | XRCC1 PNKP LIG3 | XRCC1-LIG3-PNK-TDP1 complex |
| CORUM:1086 | 9.91118107838e-08 | 0.25 | XRCC1 LIG3 POLB | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| GO:0006281 | 2.17398357357e-07 | 0.75 | APLF PNKP APTX CHD1L XRCC1 MSH3 LIG3 POLB PARP2 | DNA repair |
| CORUM:1085 | 2.47667207365e-07 | 0.25 | XRCC1 LIG3 POLB | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-73894 | 3.52985330291e-07 | 0.583333333333 | PNKP CHD1L XRCC1 PARP2 POLB LIG3 MSH3 | DNA Repair |
| REAC:R-HSA-110381 | 3.85913620733e-07 | 0.25 | XRCC1 LIG3 POLB | Resolution of AP sites via the single-nucleotide replacement pathway |
| KEGG:03410 | 3.90043013372e-07 | 0.333333333333 | XRCC1 LIG3 PARP2 POLB | Base excision repair |
| REAC:R-HSA-73884 | 1.12143038741e-06 | 0.416666666667 | XRCC1 LIG3 PARP2 PNKP POLB | Base Excision Repair |
| REAC:R-HSA-5685939 | 1.15459538873e-05 | 0.25 | XRCC1 PARP2 LIG3 | HDR through MMEJ (alt-NHEJ) |
| GO:0006259 | 1.18468298334e-05 | 0.75 | APLF PNKP APTX CHD1L XRCC1 MSH3 LIG3 POLB PARP2 | DNA metabolic process |
| GO:0006974 | 1.19962254633e-05 | 0.75 | APLF PNKP APTX CHD1L XRCC1 MSH3 LIG3 POLB PARP2 | cellular response to DNA damage stimulus |
| GO:0006288 | 1.99800867251e-05 | 0.25 | XRCC1 LIG3 POLB | base-excision repair, DNA ligation |
| GO:0006266 | 2.18648467529e-05 | 0.333333333333 | APLF XRCC1 LIG3 POLB | DNA ligation |
| CORUM:363 | 3.69160609814e-05 | 0.166666666667 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 3.69160609814e-05 | 0.166666666667 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:212 | 3.69160609814e-05 | 0.166666666667 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| REAC:R-HSA-5696399 | 0.000108750582174 | 0.333333333333 | CHD1L XRCC1 PARP2 LIG3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 0.000321758900643 | 0.333333333333 | CHD1L XRCC1 PARP2 LIG3 | Nucleotide Excision Repair |
| GO:0033554 | 0.00042951097308 | 0.833333333333 | APTX BAD PNKP APLF CHD1L XRCC1 MSH3 LIG3 POLB PARP2 | cellular response to stress |
| GO:0006302 | 0.000529289435078 | 0.5 | APLF APTX XRCC1 PARP2 LIG3 POLB | double-strand break repair |
| GO:0051103 | 0.00111635111712 | 0.25 | XRCC1 LIG3 POLB | DNA ligation involved in DNA repair |
| GO:0000012 | 0.00239001245467 | 0.25 | APLF XRCC1 APTX | single strand break repair |
| REAC:R-HSA-110362 | 0.00401394410135 | 0.166666666667 | POLB PARP2 | POLB-Dependent Long Patch Base Excision Repair |
| GO:0140097 | 0.00783507003224 | 0.416666666667 | APLF APTX LIG3 CHD1L POLB | catalytic activity, acting on DNA |
| HP:0000570 | 0.0111175836489 | 0.25 | XRCC1 PNKP APTX | Abnormal saccadic eye movements |
| HPA:035010_13 | 0.0165665926843 | 0.333333333333 | XRCC1 LIG3 PNKP APTX | placenta; decidual cells[Supported,High] |
| HPA:014020_13 | 0.0182892849916 | 0.333333333333 | XRCC1 LIG3 PNKP APTX | endometrium 2; glandular cells[Supported,High] |
| HP:0000657 | 0.0199067683901 | 0.25 | XRCC1 PNKP APTX | Oculomotor apraxia |
| GO:0005654 | 0.0205713159985 | 0.916666666667 | APTX PNKP APLF HLTF CHD1L XRCC1 MSH3 LIG3 POLB RNF146 PARP2 | nucleoplasm |
| HPA:009010_13 | 0.0245211452485 | 0.333333333333 | XRCC1 LIG3 PNKP APTX | cervix, uterine; glandular cells[Supported,High] |
| HPA:013020_13 | 0.02564565833 | 0.333333333333 | XRCC1 LIG3 PNKP APTX | endometrium 1; glandular cells[Supported,High] |
| HPA:044010_13 | 0.0360441659355 | 0.333333333333 | XRCC1 LIG3 PNKP APTX | skin 2; epidermal cells[Supported,High] |
| REAC:R-HSA-5693538 | 0.0372584100613 | 0.25 | XRCC1 PARP2 LIG3 | Homology Directed Repair |
| REAC:R-HSA-110373 | 0.0426804446713 | 0.166666666667 | POLB PARP2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 0.0426804446713 | 0.166666666667 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| HPA:053020_03 | 0.0436392439502 | 0.416666666667 | XRCC1 LIG3 HLTF PNKP APTX | testis; cells in seminiferous ducts[Uncertain,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC1 | POLB | 1.0 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM hein (XRCC1) |
| POLB | LIG3 | 0.999 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM |
| APLF | LIG3 | 0.938 | 0.85 | bioplex (APLF) bioplex_WMM |
| POLB | PNKP | 0.882 | 0.818 | hein_WMM bioplex (POLB) bioplex_WMM |
| PARP2 | APLF | 0.543 | 0.644 | bioplex (APLF) bioplex_WMM |
| PARP2 | RNF146 | 0.404 | 0.563 | bioplex (RNF146) bioplex_WMM |
| XRCC1 | LIG3 | 0.186 | 0.441 | hein_WMM bioplex_WMM youn_WMM hein (XRCC1) gupta_WMM |
| XRCC1 | APLF | 0.157 | 0.416 | bioplex (APLF) bioplex_WMM |
| POLB | PARP2 | 0.092 | 0.355 | bioplex (POLB) bioplex_WMM |
| APTX | POLB | 0.078 | 0.352 | hein_WMM bioplex (POLB) bioplex_WMM |
| CHD1L | RNF146 | 0.077 | 0.352 | bioplex (CHD1L,RNF146) bioplex_WMM |
| HLTF | APLF | 0.056 | 0.313 | bioplex (APLF) bioplex_WMM |
| PARP2 | CHD1L | 0.047 | 0.291 | bioplex (CHD1L) bioplex_WMM |
| MSH3 | APLF | 0.036 | 0.263 | bioplex (APLF) bioplex_WMM |
| HLTF | CHD1L | 0.032 | 0.245 | bioplex (CHD1L) bioplex_WMM |
| H2AC11 | APLF | 0.03 | 0.235 | bioplex (APLF) bioplex_WMM |
| APTX | BAD | 0.024 | 0.213 | hein_WMM bioplex (APTX) bioplex_WMM |
| POLB | APLF | 0.02 | 0.185 | bioplex (APLF,POLB) bioplex_WMM |
| XRCC1 | APTX | 0.016 | 0.155 | hein_WMM bioplex_WMM hein (XRCC1) |
| XRCC1 | PNKP | 0.012 | 0.15 | hein_WMM bioplex_WMM hein (XRCC1) |
| APTX | PNKP | 0.012 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| PARP2 | LIG3 | 0.012 | 0.147 | bioplex_WMM WMM_only |
| HLTF | LIG3 | 0.011 | 0.14 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HLTF | XRCC1 | 0.01 | 0.13 | bioplex_WMM youn_WMM WMM_only |
| XRCC1 | PARP2 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| XRCC1 | CHD1L | 0.009 | 0.107 | bioplex (CHD1L) bioplex_WMM |
| HLTF | PARP2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| XRCC1 | MSH3 | 0.009 | 0.097 | bioplex_WMM youn_WMM WMM_only |
| MSH3 | POLB | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MSH3 | LIG3 | 0.008 | 0.088 | bioplex_WMM youn_WMM WMM_only |
| LIG3 | PNKP | 0.008 | 0.081 | hein_WMM bioplex_WMM WMM_only |
| APTX | APLF | 0.008 | 0.084 | bioplex_WMM WMM_only |
| APLF | PNKP | 0.008 | 0.067 | bioplex_WMM WMM_only |
| XRCC1 | RNF146 | 0.008 | 0.062 | bioplex_WMM WMM_only |
| MSH3 | CHD1L | 0.008 | 0.059 | bioplex_WMM WMM_only |
| APTX | LIG3 | 0.008 | 0.043 | hein_WMM bioplex_WMM WMM_only |
| HLTF | MSH3 | 0.008 | 0.041 | bioplex_WMM youn_WMM WMM_only |
| LIG3 | CHD1L | 0.008 | 0.042 | bioplex_WMM WMM_only |
| POLB | CHD1L | 0.008 | 0.029 | bioplex_WMM WMM_only |
| H2AC11 | PARP2 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| MSH3 | PARP2 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| APTX | PARP2 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| PARP2 | PNKP | 0.007 | 0.007 | bioplex_WMM WMM_only |
| HLTF | APTX | 0.007 | 0.006 | bioplex_WMM WMM_only |
| HLTF | PNKP | 0.007 | 0.001 | bioplex_WMM WMM_only |
| MSH3 | PNKP | 0.007 | 0.002 | youn_WMM WMM_only |
| MSH3 | H2AC11 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| H2AC11 | LIG3 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| APTX | H2AC11 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| XRCC1 | H2AC11 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| H2AC11 | PNKP | 0.007 | 0.004 | bioplex_WMM WMM_only |
| H2AC11 | CHD1L | 0.006 | 0.005 | bioplex_WMM WMM_only |
| HLTF | H2AC11 | 0.005 | 0.009 | bioplex_WMM WMM_only |
| POLB | H2AC11 | 0.004 | 0.009 | bioplex (POLB) bioplex_WMM |
| APLF | CHD1L | 0.0 | 0.014 | bioplex (APLF) bioplex_WMM |
| LIG3 | RNF146 | 0.0 | 0.011 | bioplex (RNF146) bioplex_WMM |
| HLTF | RNF146 | 0.0 | 0.0 | bioplex (RNF146) bioplex_WMM |
| HLTF | POLB | 0.0 | 0.0 | hein_WMM bioplex (POLB) bioplex_WMM |
Images
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Complex HuMAP2_00315 has an average edge precision of 0.181 which is ranked 6417 out of all 6965 complexes.
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