hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00317
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | UniProt NCBI |
| SPHK1 | Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-) | UniProt NCBI |
| CBR1 | Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) | UniProt NCBI |
| GGACT | Gamma-glutamylaminecyclotransferase (GGACT) (EC 4.3.2.8) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase) | UniProt NCBI |
| UBE2C | Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) | UniProt NCBI |
| DCXR | L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H) | UniProt NCBI |
| PPIL3 | Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6296 | 0.0499886427319 | 0.142857142857 | CYLD | SPATA2-CYLD complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SPHK1 | DCXR | 0.327 | 0.515 | bioplex (SPHK1) bioplex_WMM |
| UBE2C | DCXR | 0.198 | 0.451 | fraction |
| PPIL3 | UBE2C | 0.05 | 0.298 | fraction |
| GGACT | UBE2C | 0.049 | 0.293 | fraction |
| GGACT | CBR1 | 0.043 | 0.269 | fraction |
| CYLD | SPHK1 | 0.04 | 0.268 | bioplex (SPHK1) bioplex_WMM |
| CBR1 | DCXR | 0.032 | 0.245 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| PPIL3 | DCXR | 0.028 | 0.231 | bioplex_WMM youn_WMM fraction |
| PPIL3 | GGACT | 0.027 | 0.232 | fraction |
| GGACT | DCXR | 0.018 | 0.182 | fraction |
| CYLD | DCXR | 0.007 | 0.007 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CYLD | CBR1 | 0.007 | 0.002 | gupta_WMM WMM_only |
| PPIL3 | CYLD | 0.007 | 0.0 | youn_WMM gupta_WMM WMM_only |
| UBE2C | CBR1 | 0.0 | 0.001 | fraction |
| PPIL3 | CBR1 | 0.0 | 0.0 | bioplex_WMM fraction |
Images
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Complex HuMAP2_00317 has an average edge precision of 0.2 which is ranked 6181 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CYLD | HuMAP2_00317 HuMAP2_02980 HuMAP2_06270 HuMAP2_06640 |
| SPHK1 | HuMAP2_00317 HuMAP2_06270 HuMAP2_06640 |
| CBR1 | HuMAP2_00317 HuMAP2_03473 HuMAP2_04263 HuMAP2_06771 |
| GGACT | HuMAP2_00292 HuMAP2_00317 |
| UBE2C | HuMAP2_00292 HuMAP2_00317 HuMAP2_02285 HuMAP2_02626 HuMAP2_05954 |
| DCXR | HuMAP2_00317 HuMAP2_01044 |
| PPIL3 | HuMAP2_00174 HuMAP2_00292 HuMAP2_00317 HuMAP2_02285 HuMAP2_02690 HuMAP2_05912 |