hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00326
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| XAB2 | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | UniProt NCBI |
| CDC40 | Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (EH-binding protein 3) (Ehb3) (PRP17 homolog) (hPRP17) | UniProt NCBI |
| CRNKL1 | Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) | UniProt NCBI |
| CWC15 | Spliceosome-associated protein CWC15 homolog | UniProt NCBI |
| SYF2 | Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29) | UniProt NCBI |
| SNW1 | SNW domain-containing protein 1 (Nuclear protein SkiP) (Nuclear receptor coactivator NCoA-62) (Ski-interacting protein) | UniProt NCBI |
| ISY1 | Pre-mRNA-splicing factor ISY1 homolog | UniProt NCBI |
| PPIE | Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) | UniProt NCBI |
| AQR | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | UniProt NCBI |
| ZNF830 | Zinc finger protein 830 (Coiled-coil domain-containing protein 16) | UniProt NCBI |
| CCDC12 | Coiled-coil domain-containing protein 12 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 8.87857189285e-19 | 0.909090909091 | CWC15 SYF2 ISY1 CCDC12 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | Spliceosome |
| CORUM:1181 | 6.78747633488e-18 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | C complex spliceosome |
| GO:0005684 | 2.38326387952e-17 | 0.909090909091 | CWC15 SYF2 ISY1 CCDC12 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | U2-type spliceosomal complex |
| GO:0071007 | 8.02343691052e-16 | 0.727272727273 | CWC15 SYF2 SNW1 XAB2 CDC40 CRNKL1 PPIE AQR | U2-type catalytic step 2 spliceosome |
| CORUM:351 | 1.61761212325e-15 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | Spliceosome |
| GO:0005681 | 8.95260400618e-15 | 0.909090909091 | CWC15 SYF2 ISY1 CCDC12 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | spliceosomal complex |
| GO:0071013 | 9.03523842178e-15 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | catalytic step 2 spliceosome |
| REAC:R-HSA-72163 | 4.79664347355e-14 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 7.18206213915e-14 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | mRNA Splicing |
| REAC:R-HSA-72203 | 6.10462268294e-13 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0000377 | 1.83670786788e-09 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 1.83670786788e-09 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | mRNA splicing, via spliceosome |
| GO:0000375 | 2.00340749077e-09 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | RNA splicing, via transesterification reactions |
| GO:0071014 | 4.85779854403e-09 | 0.454545454545 | ISY1 CCDC12 XAB2 SYF2 CRNKL1 | post-mRNA release spliceosomal complex |
| REAC:R-HSA-8953854 | 6.23810581973e-09 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | Metabolism of RNA |
| GO:0008380 | 8.61679193677e-09 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | RNA splicing |
| GO:0006397 | 1.66721213673e-08 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | mRNA processing |
| REAC:R-HSA-6781823 | 4.68724748641e-08 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | Formation of TC-NER Pre-Incision Complex |
| GO:1990904 | 5.41100156397e-08 | 0.909090909091 | CWC15 SYF2 ISY1 CCDC12 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | ribonucleoprotein complex |
| REAC:R-HSA-6782210 | 1.24075795382e-07 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.34370177814e-07 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 3.41929901546e-07 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696398 | 1.9610564103e-06 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | Nucleotide Excision Repair |
| GO:0016071 | 3.17172517553e-06 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | mRNA metabolic process |
| GO:0000974 | 5.73667537032e-06 | 0.363636363636 | ISY1 XAB2 SYF2 CRNKL1 | Prp19 complex |
| GO:0006396 | 6.46388122301e-06 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | RNA processing |
| GO:0006283 | 5.55613333118e-05 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | transcription-coupled nucleotide-excision repair |
| GO:1902494 | 0.00031759147892 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | catalytic complex |
| GO:0006289 | 0.000353351292924 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | nucleotide-excision repair |
| REAC:R-HSA-73894 | 0.000410581001225 | 0.454545454545 | ZNF830 ISY1 AQR XAB2 PPIE | DNA Repair |
| CORUM:0000000 | 0.00414038065946 | 0.818181818182 | CWC15 SYF2 ISY1 XAB2 CDC40 PPIE CRNKL1 AQR SNW1 | CORUM root |
| GO:0044428 | 0.0345199601716 | 1.0 | CWC15 SYF2 ISY1 CCDC12 XAB2 CDC40 PPIE ZNF830 CRNKL1 AQR SNW1 | nuclear part |
| GO:0003723 | 0.0446190274935 | 0.727272727273 | CWC15 SYF2 ISY1 CDC40 CRNKL1 PPIE AQR SNW1 | RNA binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPIE | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo fraction |
| ISY1 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (CRNKL1) Malo fraction |
| PPIE | XAB2 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM Malo fraction |
| CRNKL1 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo gupta_WMM fraction treiber_WMM |
| PPIE | ISY1 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru Malo fraction |
| ISY1 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| PPIE | AQR | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM Malo fraction |
| CRNKL1 | XAB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo gupta_WMM fraction treiber_WMM |
| XAB2 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| ISY1 | XAB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| SNW1 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SNW1) gupta_WMM fraction treiber_WMM |
| CDC40 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) fraction treiber_WMM |
| SNW1 | CCDC12 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SNW1) fraction |
| SNW1 | CDC40 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (SNW1) fraction treiber_WMM |
| PPIE | CCDC12 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM hein (CCDC12) fraction |
| CRNKL1 | SYF2 | 1.0 | 0.949 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM hein (CRNKL1) |
| SNW1 | SYF2 | 1.0 | 0.949 | hein_WMM bioplex (SYF2) bioplex_WMM Guru youn_WMM hein (SNW1) fraction |
| PPIE | ZNF830 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM youn_WMM |
| CDC40 | CCDC12 | 0.999 | 0.948 | hein_WMM bioplex_WMM Guru youn_WMM hein (CCDC12) fraction |
| CRNKL1 | CCDC12 | 0.999 | 0.948 | hein_WMM bioplex_WMM Guru youn_WMM hein (CCDC12,CRNKL1) fraction |
| SNW1 | PPIE | 0.998 | 0.935 | hein_WMM bioplex (PPIE) bioplex_WMM youn_WMM hein (SNW1) |
| SNW1 | XAB2 | 0.996 | 0.928 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) gupta_WMM treiber_WMM |
| CCDC12 | AQR | 0.987 | 0.901 | hein_WMM bioplex_WMM Guru youn_WMM hein (CCDC12) fraction |
| SNW1 | ISY1 | 0.967 | 0.879 | hein_WMM bioplex_WMM hein (SNW1) |
| XAB2 | CCDC12 | 0.967 | 0.878 | hein_WMM bioplex_WMM youn_WMM hein (CCDC12) |
| SNW1 | CWC15 | 0.946 | 0.857 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) gupta_WMM |
| ISY1 | CCDC12 | 0.943 | 0.856 | hein_WMM bioplex_WMM hein (CCDC12) |
| CRNKL1 | CWC15 | 0.887 | 0.818 | hein_WMM bioplex_WMM youn_WMM hein (CRNKL1) gupta_WMM |
| SNW1 | AQR | 0.869 | 0.803 | hein_WMM bioplex_WMM youn_WMM hein (SNW1) gupta_WMM |
| AQR | ZNF830 | 0.82 | 0.773 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| CDC40 | AQR | 0.772 | 0.751 | hein_WMM bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| SYF2 | AQR | 0.77 | 0.749 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| XAB2 | ZNF830 | 0.743 | 0.739 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| CDC40 | ISY1 | 0.723 | 0.732 | hein_WMM bioplex_WMM Guru fraction |
| CDC40 | XAB2 | 0.719 | 0.73 | hein_WMM bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| XAB2 | SYF2 | 0.668 | 0.701 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| PPIE | SYF2 | 0.633 | 0.682 | hein_WMM bioplex (PPIE,SYF2) bioplex_WMM youn_WMM fraction |
| ISY1 | SYF2 | 0.466 | 0.604 | hein_WMM bioplex (SYF2) bioplex_WMM |
| CDC40 | SYF2 | 0.435 | 0.579 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| SYF2 | CCDC12 | 0.34 | 0.528 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| CRNKL1 | ZNF830 | 0.309 | 0.502 | hein_WMM bioplex_WMM youn_WMM hein (CRNKL1) gupta_WMM |
| PPIE | CDC40 | 0.053 | 0.301 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| ISY1 | ZNF830 | 0.044 | 0.28 | hein_WMM bioplex_WMM fraction |
| SYF2 | CWC15 | 0.033 | 0.245 | hein_WMM bioplex (SYF2) bioplex_WMM youn_WMM |
| XAB2 | CWC15 | 0.018 | 0.178 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PPIE | CWC15 | 0.017 | 0.166 | hein_WMM bioplex (PPIE) bioplex_WMM youn_WMM |
| CWC15 | AQR | 0.013 | 0.142 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC40 | CWC15 | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CCDC12 | ZNF830 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SYF2 | ZNF830 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CDC40 | ZNF830 | 0.01 | 0.139 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SNW1 | ZNF830 | 0.009 | 0.108 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CWC15 | ZNF830 | 0.009 | 0.108 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CWC15 | CCDC12 | 0.008 | 0.074 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ISY1 | CWC15 | 0.008 | 0.045 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00326 has an average edge precision of 0.675 which is ranked 1482 out of all 6965 complexes.
Related Complexes