hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00328
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FOPNL | LisH domain-containing protein FOPNL (FGFR1OP N-terminal-like protein) (FOP-related protein of 20 kDa) | UniProt NCBI |
| CEP131 | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | UniProt NCBI |
| KIAA0753 | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | UniProt NCBI |
| PIBF1 | Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) | UniProt NCBI |
| CSPP1 | Centrosome and spindle pole-associated protein 1 | UniProt NCBI |
| SSX2IP | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | UniProt NCBI |
| OFD1 | Oral-facial-digital syndrome 1 protein (Protein 71-7A) | UniProt NCBI |
| CCDC138 | Coiled-coil domain-containing protein 138 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0034451 | 1.63341960744e-11 | 0.75 | PIBF1 SSX2IP OFD1 CEP131 FOPNL KIAA0753 | centriolar satellite |
| CORUM:6441 | 4.70911134935e-09 | 0.375 | KIAA0753 FOPNL OFD1 | KIAA0753-FOR20-OFD1 complex |
| HP:0002876 | 7.02912345698e-07 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Episodic tachypnea |
| HP:0002419 | 1.03534793477e-06 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Molar tooth sign on MRI |
| GO:0044450 | 1.0573550517e-06 | 0.75 | PIBF1 SSX2IP OFD1 CEP131 FOPNL KIAA0753 | microtubule organizing center part |
| HP:0002418 | 5.55865351084e-06 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Abnormality of midbrain morphology |
| WP:WP4536 | 7.48061058091e-06 | 0.5 | KIAA0753 PIBF1 FOPNL OFD1 | Genes related to primary cilium development (based on CRISPR) |
| GO:0005813 | 9.1040811603e-06 | 0.875 | PIBF1 SSX2IP OFD1 CSPP1 CEP131 FOPNL KIAA0753 | centrosome |
| HP:0004422 | 1.08257028835e-05 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Biparietal narrowing |
| GO:0005815 | 6.27827537999e-05 | 0.875 | PIBF1 SSX2IP OFD1 CSPP1 CEP131 FOPNL KIAA0753 | microtubule organizing center |
| HP:0002789 | 7.0144551869e-05 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Tachypnea |
| HP:0001829 | 7.63095061024e-05 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Foot polydactyly |
| HP:0009136 | 8.98445670242e-05 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Duplication involving bones of the feet |
| HP:0002553 | 0.000151668410454 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Highly arched eyebrow |
| WP:WP4656 | 0.000314558710632 | 0.375 | OFD1 CSPP1 PIBF1 | Joubert Syndrome |
| HP:0001161 | 0.000465178107088 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Hand polydactyly |
| HP:0000426 | 0.00058569988894 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Prominent nasal bridge |
| HP:0001320 | 0.000615368796977 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Cerebellar vermis hypoplasia |
| HP:0000276 | 0.000630616443076 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Long face |
| HP:0009997 | 0.000799046684664 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Duplication of phalanx of hand |
| HP:0004275 | 0.000817560682485 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Duplication of hand bones |
| HP:0009142 | 0.000817560682485 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Duplication of bones involving the upper extremities |
| HP:0100729 | 0.00099891831074 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Large face |
| HP:0006817 | 0.00099891831074 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Aplasia/Hypoplasia of the cerebellar vermis |
| GO:0015630 | 0.00140172168705 | 0.875 | PIBF1 SSX2IP OFD1 CSPP1 CEP131 FOPNL KIAA0753 | microtubule cytoskeleton |
| HP:0010442 | 0.00142119754348 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Polydactyly |
| HP:0002104 | 0.00144959409952 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Apnea |
| HP:0002334 | 0.00162894077071 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Abnormality of the cerebellar vermis |
| HP:0100258 | 0.00315443340696 | 0.375 | KIAA0753 CSPP1 OFD1 | Preaxial polydactyly |
| HP:0002438 | 0.00383588648284 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Cerebellar malformation |
| HP:0009084 | 0.00464310919637 | 0.25 | KIAA0753 OFD1 | Midline notch of upper alveolar ridge |
| HP:0007036 | 0.00464310919637 | 0.25 | KIAA0753 OFD1 | Hypoplasia of olfactory tract |
| HP:0006145 | 0.0059681081945 | 0.25 | KIAA0753 OFD1 | Central Y-shaped metacarpal |
| HP:0002793 | 0.00652310326714 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Abnormal pattern of respiration |
| GO:0036064 | 0.00710535428194 | 0.5 | CEP131 OFD1 FOPNL SSX2IP | ciliary basal body |
| HP:0001696 | 0.00718764035184 | 0.375 | OFD1 CSPP1 PIBF1 | Situs inversus totalis |
| HP:0011534 | 0.00743649290337 | 0.375 | OFD1 CSPP1 PIBF1 | Abnormal spatial orientation of the cardiac segments |
| HP:0002444 | 0.00745813121128 | 0.25 | KIAA0753 OFD1 | Hypothalamic hamartoma |
| GO:0044430 | 0.0075667656243 | 0.875 | PIBF1 SSX2IP OFD1 CSPP1 CEP131 FOPNL KIAA0753 | cytoskeletal part |
| HP:0000199 | 0.00911304494741 | 0.25 | KIAA0753 OFD1 | Tongue nodules |
| HP:0002269 | 0.0100380518138 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Abnormality of neuronal migration |
| HP:0001651 | 0.0102449952412 | 0.375 | OFD1 CSPP1 PIBF1 | Dextrocardia |
| HP:0004307 | 0.0105591815374 | 0.375 | OFD1 CSPP1 PIBF1 | Abnormal anatomic location of the heart |
| HP:0008872 | 0.0106536183546 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Feeding difficulties in infancy |
| HP:0006042 | 0.0109327161708 | 0.25 | KIAA0753 OFD1 | Y-shaped metacarpals |
| GO:0060271 | 0.0117853463511 | 0.625 | CEP131 OFD1 PIBF1 FOPNL SSX2IP | cilium assembly |
| HP:0000180 | 0.0129170117165 | 0.25 | KIAA0753 OFD1 | Lobulated tongue |
| HP:0002280 | 0.0129170117165 | 0.25 | OFD1 CSPP1 | Enlarged cisterna magna |
| HP:0012286 | 0.0129170117165 | 0.25 | KIAA0753 OFD1 | Abnormal hypothalamus morphology |
| HP:0009731 | 0.0129170117165 | 0.25 | KIAA0753 OFD1 | Cerebral hamartoma |
| GO:0044782 | 0.0152465526992 | 0.625 | CEP131 OFD1 PIBF1 FOPNL SSX2IP | cilium organization |
| GO:0071539 | 0.0165565880345 | 0.375 | CEP131 PIBF1 KIAA0753 | protein localization to centrosome |
| HP:0100260 | 0.0173789434513 | 0.25 | KIAA0753 OFD1 | Mesoaxial polydactyly |
| GO:1905508 | 0.0184623087477 | 0.375 | CEP131 PIBF1 KIAA0753 | protein localization to microtubule organizing center |
| HP:0000534 | 0.0194177421944 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Abnormal eyebrow morphology |
| HP:0011802 | 0.0224977761754 | 0.25 | KIAA0753 OFD1 | Hamartoma of tongue |
| HP:0001337 | 0.0236440048252 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Tremor |
| HP:0000463 | 0.0312080963796 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Anteverted nares |
| HP:0008689 | 0.0314053898103 | 0.25 | KIAA0753 OFD1 | Bilateral cryptorchidism |
| GO:0005856 | 0.0335519954693 | 0.875 | PIBF1 SSX2IP OFD1 CSPP1 CEP131 FOPNL KIAA0753 | cytoskeleton |
| HP:0005288 | 0.0346840999967 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Abnormality of the nares |
| HP:0000202 | 0.0390909094316 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Oral cleft |
| HP:0001163 | 0.0438943206699 | 0.375 | KIAA0753 CSPP1 OFD1 | Abnormality of the metacarpal bones |
| HP:0001737 | 0.0455714500205 | 0.25 | OFD1 CSPP1 | Pancreatic cysts |
| HP:0001780 | 0.0460844332052 | 0.5 | KIAA0753 PIBF1 CSPP1 OFD1 | Abnormality of toe |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KIAA0753 | OFD1 | 0.988 | 0.901 | hein_WMM gupta (KIAA0753,OFD1) youn_WMM hein (OFD1) gupta_WMM |
| CEP131 | OFD1 | 0.987 | 0.901 | hein_WMM gupta (OFD1) youn_WMM hein (CEP131,OFD1) gupta_WMM |
| CEP131 | CCDC138 | 0.982 | 0.897 | hein_WMM bioplex_WMM youn_WMM hein (CEP131) gupta_WMM |
| CEP131 | PIBF1 | 0.978 | 0.894 | hein_WMM bioplex_WMM boldt (PIBF1) youn_WMM hein (CEP131) gupta_WMM boldt_WMM |
| OFD1 | PIBF1 | 0.978 | 0.894 | hein_WMM gupta (OFD1) youn_WMM hein (OFD1) gupta_WMM |
| OFD1 | CCDC138 | 0.975 | 0.887 | hein_WMM gupta (OFD1) youn_WMM hein (OFD1) gupta_WMM |
| CSPP1 | OFD1 | 0.973 | 0.886 | hein_WMM gupta (OFD1) youn_WMM hein (OFD1) gupta_WMM |
| CSPP1 | CEP131 | 0.961 | 0.867 | hein_WMM youn_WMM hein (CEP131) gupta_WMM |
| CEP131 | SSX2IP | 0.951 | 0.858 | hein_WMM bioplex_WMM gupta (SSX2IP) youn_WMM hein (CEP131) gupta_WMM |
| CEP131 | KIAA0753 | 0.949 | 0.858 | hein_WMM gupta (KIAA0753) youn_WMM hein (CEP131) gupta_WMM |
| SSX2IP | OFD1 | 0.815 | 0.773 | hein_WMM gupta (OFD1,SSX2IP) youn_WMM hein (OFD1) gupta_WMM |
| FOPNL | OFD1 | 0.549 | 0.643 | hein_WMM gupta (OFD1) hein (OFD1) gupta_WMM |
| SSX2IP | PIBF1 | 0.101 | 0.364 | hein_WMM gupta (SSX2IP) youn_WMM gupta_WMM |
| CEP131 | FOPNL | 0.055 | 0.309 | hein_WMM hein (CEP131) gupta_WMM |
| KIAA0753 | SSX2IP | 0.038 | 0.263 | hein_WMM gupta (KIAA0753,SSX2IP) youn_WMM gupta_WMM |
| KIAA0753 | FOPNL | 0.034 | 0.261 | hein_WMM gupta (KIAA0753) gupta_WMM |
| CSPP1 | CCDC138 | 0.024 | 0.215 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CSPP1 | PIBF1 | 0.022 | 0.195 | hein_WMM youn_WMM gupta_WMM WMM_only |
| KIAA0753 | PIBF1 | 0.021 | 0.19 | hein_WMM gupta (KIAA0753) youn_WMM gupta_WMM |
| PIBF1 | CCDC138 | 0.015 | 0.145 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CSPP1 | KIAA0753 | 0.014 | 0.141 | hein_WMM gupta (KIAA0753) youn_WMM gupta_WMM |
| SSX2IP | CCDC138 | 0.009 | 0.09 | hein_WMM gupta (SSX2IP) youn_WMM gupta_WMM |
| FOPNL | CCDC138 | 0.009 | 0.09 | hein_WMM gupta_WMM WMM_only |
| CSPP1 | FOPNL | 0.009 | 0.093 | hein_WMM gupta_WMM WMM_only |
| FOPNL | PIBF1 | 0.008 | 0.042 | hein_WMM gupta_WMM WMM_only |
| FOPNL | SSX2IP | 0.007 | 0.006 | hein_WMM gupta_WMM WMM_only |
| KIAA0753 | CCDC138 | 0.007 | 0.001 | hein_WMM gupta (KIAA0753) youn_WMM gupta_WMM |
| CSPP1 | SSX2IP | 0.006 | 0.008 | hein_WMM youn_WMM gupta_WMM gupta (SSX2IP) |
Images
Click to enlarge
Complex HuMAP2_00328 has an average edge precision of 0.453 which is ranked 2858 out of all 6965 complexes.
Related Complexes