hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00333

Confidence: Medium

Genename	Protein Name	Links
RPGRIP1L	Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)	UniProt NCBI
RPGR	X-linked retinitis pigmentosa GTPase regulator	UniProt NCBI
GKAP1	G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa)	UniProt NCBI
NEK4	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)	UniProt NCBI
PDE6D	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)	UniProt NCBI
NPHP4	Nephrocystin-4 (Nephroretinin)	UniProt NCBI
NPHP1	Nephrocystin-1 (Juvenile nephronophthisis 1 protein)	UniProt NCBI
RPGRIP1	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4656	1.85353746388e-06	0.5	RPGRIP1L NPHP1 PDE6D NPHP4	Joubert Syndrome
HP:0002612	2.49454652724e-06	0.5	RPGRIP1L NPHP1 NPHP4 RPGRIP1	Congenital hepatic fibrosis
CORUM:6741	3.50546248845e-05	0.25	RPGR PDE6D	INPP5E-PDE6D-RPGR complex
CORUM:6381	3.50546248845e-05	0.25	NPHP1 NPHP4	NPHP1-NPHP4-BCAR1 complex
HP:0000556	3.76887907543e-05	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	Retinal dystrophy
HP:0001162	4.91289434064e-05	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Postaxial hand polydactyly
CORUM:6681	7.00904180673e-05	0.25	RPGRIP1L NPHP4	DVL2-INVS-NPHP4-RPGRIP1L complex
HP:0001395	8.28706876709e-05	0.5	RPGRIP1L NPHP1 NPHP4 RPGRIP1	Hepatic fibrosis
HP:0000479	0.000143186115822	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal retinal morphology
HP:0100259	0.000157051203464	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Postaxial polydactyly
HP:0000639	0.000287513132247	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Nystagmus
HP:0012547	0.00031074193245	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal involuntary eye movements
REAC:R-HSA-5617833	0.000312480655384	0.5	RPGRIP1L NPHP1 PDE6D NPHP4	Cilium Assembly
GO:0035869	0.00038940760077	0.5	RPGRIP1L NPHP1 NPHP4 RPGRIP1	ciliary transition zone
HP:0002419	0.0003973269126	0.375	RPGRIP1L PDE6D NPHP1	Molar tooth sign on MRI
HP:0000512	0.000429458638682	0.5	RPGR NPHP1 PDE6D RPGRIP1	Abnormal electroretinogram
HP:0001161	0.000465178107088	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Hand polydactyly
HP:0000090	0.000473844223558	0.375	RPGRIP1L NPHP4 NPHP1	Nephronophthisis
GO:0005929	0.000528814020866	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	cilium
HP:0001320	0.000615368796977	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Cerebellar vermis hypoplasia
HP:0009997	0.000799046684664	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Duplication of phalanx of hand
HP:0009142	0.000817560682485	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Duplication of bones involving the upper extremities
HP:0004275	0.000817560682485	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Duplication of hand bones
HP:0100957	0.000877163019543	0.375	RPGRIP1L NPHP4 NPHP1	Abnormal renal medulla morphology
HP:0001098	0.0009950728043	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal fundus morphology
HP:0006817	0.00099891831074	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Aplasia/Hypoplasia of the cerebellar vermis
HP:0004329	0.00101406611933	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal posterior eye segment morphology
HP:0030453	0.00106554739072	0.5	RPGR NPHP1 PDE6D RPGRIP1	Abnormal visual electrophysiology
HP:0000368	0.00125941888856	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Low-set, posteriorly rotated ears
HP:0002418	0.00137682655036	0.375	RPGRIP1L PDE6D NPHP1	Abnormality of midbrain morphology
REAC:R-HSA-1852241	0.00140977665905	0.5	RPGRIP1L NPHP1 PDE6D NPHP4	Organelle biogenesis and maintenance
HP:0010442	0.00142119754348	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Polydactyly
HP:0000107	0.00159796170518	0.5	RPGRIP1L NPHP1 NPHP4 RPGRIP1	Renal cyst
HP:0012243	0.00162412867354	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal reproductive system morphology
HP:0002334	0.00162894077071	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Abnormality of the cerebellar vermis
GO:0097730	0.00204412574456	0.5	RPGR NPHP1 NPHP4 RPGRIP1	non-motile cilium
HP:0004422	0.00225729280182	0.375	RPGRIP1L PDE6D NPHP1	Biparietal narrowing
REAC:R-HSA-5620912	0.00243902745158	0.375	RPGRIP1L NPHP4 NPHP1	Anchoring of the basal body to the plasma membrane
HP:0000518	0.00251932719831	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	Cataract
HP:0001746	0.00287767946815	0.375	RPGRIP1L RPGRIP1 RPGR	Asplenia
HP:0000517	0.00291706506583	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	Abnormality of the lens
HP:0010451	0.00301395088993	0.375	RPGRIP1L RPGRIP1 RPGR	Aplasia/Hypoplasia of the spleen
HP:0100258	0.00315443340696	0.375	RPGRIP1L PDE6D RPGRIP1	Preaxial polydactyly
HP:0000078	0.00319733231997	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormality of the genital system
HP:0002438	0.00383588648284	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Cerebellar malformation
HP:0000496	0.00425741985542	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormality of eye movement
HP:0000108	0.00464310919637	0.25	NPHP1 NPHP4	Renal corticomedullary cysts
HP:0007703	0.00473003153871	0.5	RPGR NPHP1 NPHP4 RPGRIP1	Abnormality of retinal pigmentation
HP:0011844	0.00516213833898	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal appendicular skeleton morphology
HP:0000238	0.00577034281269	0.5	RPGRIP1L NPHP1 RPGRIP1 RPGR	Hydrocephalus
HP:0000035	0.00642098115251	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D RPGR	Abnormal testis morphology
HP:0002084	0.00647427912683	0.375	RPGRIP1L RPGRIP1 NPHP1	Encephalocele
HP:0011815	0.00647427912683	0.375	RPGRIP1L RPGRIP1 NPHP1	Cephalocele
HP:0002793	0.00652310326714	0.5	RPGRIP1L NPHP1 PDE6D RPGR	Abnormal pattern of respiration
HP:0010938	0.0066554649482	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D RPGR	Abnormality of the external nose
HP:0000358	0.00688004823047	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Posteriorly rotated ears
HP:0001696	0.00718764035184	0.375	RPGRIP1L RPGRIP1 RPGR	Situs inversus totalis
HP:0011534	0.00743649290337	0.375	RPGRIP1L RPGRIP1 RPGR	Abnormal spatial orientation of the cardiac segments
HP:0005576	0.00745813121128	0.25	NPHP1 NPHP4	Tubulointerstitial fibrosis
HP:0030760	0.00745813121128	0.25	NPHP1 NPHP4	Renal fibrosis
HP:0012210	0.00866711703966	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D NPHP4	Abnormal renal morphology
HP:0004207	0.00888640520787	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Abnormal 5th finger morphology
HP:0002789	0.00905007554403	0.375	RPGRIP1L PDE6D RPGR	Tachypnea
HP:0000003	0.00905007554403	0.375	RPGRIP1L RPGRIP1 NPHP1	Multicystic kidney dysplasia
HP:0008056	0.00933461419367	0.5	RPGRIP1L RPGRIP1 PDE6D RPGR	Aplasia/Hypoplasia affecting the eye
HP:0001829	0.00963529148538	0.375	RPGRIP1L PDE6D RPGRIP1	Foot polydactyly
HP:0002269	0.0100380518138	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Abnormality of neuronal migration
HP:0001651	0.0102449952412	0.375	RPGRIP1L RPGRIP1 RPGR	Dextrocardia
HP:0004307	0.0105591815374	0.375	RPGRIP1L RPGRIP1 RPGR	Abnormal anatomic location of the heart
HP:0009136	0.0108796714446	0.375	RPGRIP1L PDE6D RPGRIP1	Duplication involving bones of the feet
HP:0000505	0.0116393290133	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	Visual impairment
GO:0044441	0.0135294175892	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	ciliary part
HP:0000032	0.0140303519042	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D RPGR	Abnormality of male external genitalia
HP:0002553	0.0160621279887	0.375	RPGRIP1L PDE6D NPHP1	Highly arched eyebrow
HP:0001167	0.0162085838495	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D RPGR	Abnormality of finger
HP:0010461	0.0164985732463	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D RPGR	Abnormality of the male genitalia
HP:0000811	0.0165961390239	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D RPGR	Abnormal external genitalia
HP:0002921	0.0198130668967	0.5	RPGRIP1L NPHP1 RPGRIP1 RPGR	Abnormality of the cerebrospinal fluid
HP:0010459	0.0198563136463	0.25	RPGRIP1L RPGRIP1	True hermaphroditism
HP:0000092	0.0198563136463	0.25	NPHP1 NPHP4	Tubular atrophy
HP:0006870	0.0198563136463	0.25	RPGRIP1L RPGRIP1	Lobar holoprosencephaly
HP:0012758	0.0214525833514	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Neurodevelopmental delay
HP:0012043	0.0224977761754	0.25	RPGR RPGRIP1	Pendular nystagmus
HP:0000550	0.0282724469862	0.25	PDE6D RPGRIP1	Undetectable electroretinogram
HP:0000504	0.0286112512856	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	Abnormality of vision
HP:0000175	0.0287750086045	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Cleft palate
HP:0100737	0.0290381948062	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Abnormal hard palate morphology
HP:0000510	0.029554721474	0.375	RPGR NPHP4 NPHP1	Rod-cone dystrophy
HP:0004328	0.0296772976714	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	Abnormal anterior eye segment morphology
HP:0002012	0.0310935229292	0.625	RPGRIP1L RPGRIP1 NPHP1 NPHP4 RPGR	Abnormality of the abdominal organs
HP:0000463	0.0312080963796	0.5	RPGRIP1L NPHP1 PDE6D RPGR	Anteverted nares
HP:0100732	0.0314053898103	0.25	RPGRIP1L RPGRIP1	Pancreatic fibrosis
HP:0000103	0.0314053898103	0.25	NPHP1 NPHP4	Polyuria
HP:0000077	0.0323964751761	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D NPHP4	Abnormality of the kidney
HP:0005288	0.0346840999967	0.5	RPGRIP1L NPHP1 PDE6D RPGR	Abnormality of the nares
HP:0012372	0.0360693442595	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal eye morphology
HP:0010935	0.0371136074298	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D NPHP4	Abnormality of the upper urinary tract
GO:1903348	0.0378589948753	0.25	NPHP1 NPHP4	positive regulation of bicellular tight junction assembly
HP:0000068	0.0381618271547	0.25	RPGRIP1L RPGRIP1	Urethral atresia
HP:0000202	0.0390909094316	0.5	RPGRIP1L NPHP1 PDE6D RPGRIP1	Oral cleft
HP:0012373	0.0411786056118	0.75	PDE6D NPHP1 RPGR RPGRIP1L RPGRIP1 NPHP4	Abnormal eye physiology
HP:0011297	0.0421499585418	0.625	RPGRIP1L RPGRIP1 NPHP1 PDE6D RPGR	Abnormal digit morphology
HP:0000426	0.0438943206699	0.375	RPGRIP1L PDE6D NPHP1	Prominent nasal bridge
HP:0000548	0.0455714500205	0.25	RPGR RPGRIP1	Cone/cone-rod dystrophy
HP:0001737	0.0455714500205	0.25	RPGRIP1L RPGRIP1	Pancreatic cysts
HP:0000276	0.0463747669761	0.375	RPGRIP1L PDE6D NPHP1	Long face
HP:0011314	0.0495146655034	0.5	RPGRIP1L NPHP1 NPHP4 RPGRIP1	Abnormality of long bone morphology
HP:0001747	0.0495208749973	0.25	RPGRIP1L RPGRIP1	Accessory spleen
CORUM:7242	0.0497224828424	0.125	RPGRIP1	RPGRIP1-SPATA7 complex
CORUM:6743	0.0497224828424	0.125	NPHP1	AHI1-NPHP1 heterodimer
CORUM:6660	0.0497224828424	0.125	NPHP4	LATS1-NPHP4 complex
CORUM:6750	0.0497224828424	0.125	NPHP1	AHI1-NPHP1 heterotetramer
CORUM:6600	0.0497224828424	0.125	NPHP1	NPHP1-PKD1 complex
CORUM:6342	0.0497224828424	0.125	NPHP4	Jade-1-NPHP4 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RPGRIP1L	RPGR	1.0	0.949	bioplex (RPGR) bioplex_WMM gupta (RPGR,RPGRIP1L) boldt (RPGRIP1L) boldt_WMM
RPGR	NPHP4	0.998	0.943	bioplex (RPGR) bioplex_WMM gupta (RPGR) boldt gupta_WMM boldt_WMM
NPHP4	NPHP1	0.946	0.857	bioplex_WMM gupta (NPHP1,NPHP4) boldt (NPHP4) gupta_WMM boldt_WMM
RPGRIP1L	NPHP4	0.912	0.835	bioplex_WMM gupta (RPGRIP1L) boldt (RPGRIP1L) youn_WMM gupta_WMM boldt_WMM
RPGRIP1L	GKAP1	0.246	0.469	gupta (RPGRIP1L) boldt (RPGRIP1L) youn_WMM boldt_WMM
RPGRIP1L	NEK4	0.203	0.453	gupta (RPGRIP1L) boldt (RPGRIP1L) youn_WMM boldt_WMM
RPGRIP1L	NPHP1	0.185	0.439	bioplex_WMM gupta (NPHP1,RPGRIP1L) boldt (RPGRIP1L) gupta_WMM boldt_WMM
RPGR	RPGRIP1	0.17	0.427	gupta (RPGRIP1) boldt (RPGRIP1) boldt_WMM
PDE6D	RPGR	0.095	0.359	bioplex (RPGR) bioplex_WMM boldt (RPGR) boldt_WMM
RPGR	NPHP1	0.039	0.263	bioplex (RPGR) bioplex_WMM boldt gupta_WMM boldt_WMM
NEK4	RPGRIP1	0.039	0.264	gupta (RPGRIP1) boldt (RPGRIP1) boldt_WMM
RPGRIP1L	PDE6D	0.008	0.089	bioplex_WMM boldt (RPGRIP1L) boldt_WMM
NPHP4	RPGRIP1	0.008	0.079	gupta (RPGRIP1)
NEK4	RPGR	0.008	0.011	boldt gupta_WMM boldt_WMM
PDE6D	NPHP1	0.007	0.01	bioplex_WMM boldt boldt_WMM
PDE6D	NPHP4	0.007	0.006	bioplex_WMM boldt boldt_WMM
NEK4	NPHP4	0.007	0.003	bioplex_WMM boldt gupta_WMM boldt_WMM
NEK4	GKAP1	0.007	0.005	boldt youn_WMM gupta_WMM boldt_WMM
NEK4	NPHP1	0.007	0.005	boldt gupta_WMM boldt_WMM
NPHP1	GKAP1	0.007	0.004	boldt gupta_WMM boldt_WMM
RPGR	GKAP1	0.007	0.006	boldt gupta_WMM boldt_WMM
NPHP4	GKAP1	0.007	0.003	boldt gupta_WMM boldt_WMM
NEK4	PDE6D	0.006	0.004	boldt boldt_WMM
PDE6D	GKAP1	0.006	0.001	boldt boldt_WMM
RPGRIP1	NPHP1	0.004	0.014	gupta (RPGRIP1)

Images

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Complex HuMAP2_00333 has an average edge precision of 0.26 which is ranked 5230 out of all 6965 complexes.

Related Complexes

Genename	Complexes
RPGRIP1L	HuMAP2_00333 HuMAP2_01782 HuMAP2_05152
RPGR	HuMAP2_00333 HuMAP2_00699 HuMAP2_00864 HuMAP2_01782 HuMAP2_04078 HuMAP2_05152
GKAP1	HuMAP2_00333 HuMAP2_01782
NEK4	HuMAP2_00333 HuMAP2_01782 HuMAP2_02926 HuMAP2_04021
PDE6D	HuMAP2_00333 HuMAP2_00699 HuMAP2_04078
NPHP4	HuMAP2_00333 HuMAP2_01782 HuMAP2_05152
NPHP1	HuMAP2_00333 HuMAP2_01782 HuMAP2_05152
RPGRIP1	HuMAP2_00333 HuMAP2_02817 HuMAP2_02926 HuMAP2_04021 HuMAP2_04078

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_00333