hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00337
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KANSL3 | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | UniProt NCBI |
| MSL2 | E3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) | UniProt NCBI |
| KAT8 | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF) | UniProt NCBI |
| MSL1 | Male-specific lethal 1 homolog (MSL-1) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) | UniProt NCBI |
| MSL3 | Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) | UniProt NCBI |
| MSL3P1 | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7220 | 1.81514593393e-13 | 0.8 | MSL2 KAT8 MSL3 MSL1 | MSL complex |
| GO:0043984 | 5.06916499819e-11 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | histone H4-K16 acetylation |
| GO:0072487 | 1.2197780676e-10 | 0.8 | MSL2 KAT8 MSL3 MSL1 | MSL complex |
| CORUM:610 | 5.40532307664e-09 | 0.6 | MSL2 KAT8 MSL3 | MSL complex |
| GO:1902562 | 6.13901440096e-09 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | H4 histone acetyltransferase complex |
| REAC:R-HSA-3214847 | 1.09897493916e-08 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | HATs acetylate histones |
| GO:0043967 | 2.35082526791e-08 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | histone H4 acetylation |
| GO:0000123 | 1.72940527637e-07 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | histone acetyltransferase complex |
| REAC:R-HSA-4839726 | 2.77321956546e-07 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | Chromatin organization |
| REAC:R-HSA-3247509 | 2.77321956546e-07 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | Chromatin modifying enzymes |
| GO:0031248 | 3.20924936678e-07 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | protein acetyltransferase complex |
| GO:1902493 | 3.20924936678e-07 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | acetyltransferase complex |
| GO:0016573 | 8.70872110173e-07 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | histone acetylation |
| GO:0018393 | 9.57048775295e-07 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | internal peptidyl-lysine acetylation |
| GO:0006475 | 1.20260182295e-06 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | internal protein amino acid acetylation |
| GO:0018394 | 1.25726554218e-06 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | peptidyl-lysine acetylation |
| GO:0006473 | 4.37463273806e-06 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | protein acetylation |
| GO:0043543 | 1.28973467939e-05 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | protein acylation |
| GO:0018205 | 0.000126115844807 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | peptidyl-lysine modification |
| GO:0016570 | 0.000239991949727 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | histone modification |
| CORUM:7221 | 0.000241285563976 | 0.4 | KANSL3 KAT8 | NSL complex |
| GO:0016569 | 0.000301140640782 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | covalent chromatin modification |
| GO:0006325 | 0.00448062284804 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | chromatin organization |
| GO:1990234 | 0.0112296002627 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | transferase complex |
| GO:0018193 | 0.0346157101499 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | peptidyl-amino acid modification |
| GO:0044451 | 0.0442638282809 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | nucleoplasm part |
| GO:0051276 | 0.046479053704 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | chromosome organization |
| CORUM:0000000 | 0.0474603483533 | 1.0 | KANSL3 MSL2 KAT8 MSL3 MSL1 | CORUM root |
| CORUM:724 | 0.0499494897235 | 0.2 | KAT8 | MAF2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MSL1 | KAT8 | 1.0 | 0.949 | hein_WMM bioplex (MSL1) bioplex_WMM hein (KAT8) |
| MSL1 | MSL3 | 0.985 | 0.899 | hein_WMM bioplex (MSL1) bioplex_WMM |
| MSL2 | KAT8 | 0.703 | 0.724 | hein_WMM bioplex (MSL2) bioplex_WMM hein (KAT8) |
| MSL1 | MSL3P1 | 0.638 | 0.685 | bioplex (MSL1) bioplex_WMM |
| MSL2 | MSL1 | 0.306 | 0.501 | hein_WMM bioplex (MSL2) bioplex_WMM |
| KAT8 | MSL3 | 0.146 | 0.409 | hein_WMM bioplex_WMM hein (KAT8) |
| MSL2 | MSL3 | 0.095 | 0.359 | hein_WMM bioplex (MSL2) bioplex_WMM |
| KAT8 | KANSL3 | 0.03 | 0.23 | hein_WMM bioplex_WMM hein (KAT8) |
| KAT8 | MSL3P1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| MSL3 | MSL3P1 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| KANSL3 | MSL3 | 0.008 | 0.024 | hein_WMM WMM_only |
| MSL2 | KANSL3 | 0.007 | 0.01 | hein_WMM WMM_only |
| MSL1 | KANSL3 | 0.007 | 0.001 | hein_WMM WMM_only |
Images
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Complex HuMAP2_00337 has an average edge precision of 0.384 which is ranked 3478 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KANSL3 | HuMAP2_00337 HuMAP2_00495 HuMAP2_04368 HuMAP2_04911 |
| MSL2 | HuMAP2_00337 HuMAP2_03206 HuMAP2_03592 HuMAP2_05119 |
| KAT8 | HuMAP2_00337 HuMAP2_00495 HuMAP2_03592 HuMAP2_05119 |
| MSL1 | HuMAP2_00337 HuMAP2_03153 HuMAP2_05119 HuMAP2_05861 |
| MSL3 | HuMAP2_00337 HuMAP2_03153 HuMAP2_03206 HuMAP2_05119 HuMAP2_05861 |
| MSL3P1 | HuMAP2_00337 HuMAP2_03153 HuMAP2_05119 |