hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_00343
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTNNB1 | Catenin beta-1 (Beta-catenin) | UniProt NCBI |
| CTNNA2 | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | UniProt NCBI |
| CTNNA1 | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | UniProt NCBI |
| CDH10 | Cadherin-10 (T2-cadherin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-525793 | 3.10262114446e-06 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Myogenesis |
| REAC:R-HSA-418990 | 3.94532681474e-06 | 0.75 | CTNNA1 CTNNB1 CDH10 | Adherens junctions interactions |
| CORUM:4096 | 5.02777038712e-06 | 0.5 | CTNNA1 CTNNB1 | CTNNA1-CTNNB1 complex |
| KEGG:05213 | 7.85221975235e-06 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Endometrial cancer |
| WP:WP4155 | 8.50820332609e-06 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Endometrial cancer |
| WP:WP2118 | 1.1782685669e-05 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| KEGG:04520 | 1.40519436497e-05 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Adherens junction |
| KEGG:05412 | 1.59928783462e-05 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| KEGG:05100 | 1.66774444702e-05 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-421270 | 1.78485863117e-05 | 0.75 | CTNNA1 CTNNB1 CDH10 | Cell-cell junction organization |
| KEGG:04670 | 2.94026709165e-05 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Leukocyte transendothelial migration |
| WP:WP4541 | 3.85485625527e-05 | 0.75 | CTNNA1 CTNNB1 CDH10 | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-446728 | 7.69213089466e-05 | 0.75 | CTNNA1 CTNNB1 CDH10 | Cell junction organization |
| KEGG:05226 | 9.7891531883e-05 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Gastric cancer |
| KEGG:04390 | 0.000124834325776 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Hippo signaling pathway |
| REAC:R-HSA-1500931 | 0.000237627678426 | 0.75 | CTNNA1 CTNNB1 CDH10 | Cell-Cell communication |
| GO:0016342 | 0.000558907067709 | 0.75 | CTNNA1 CTNNB1 CDH10 | catenin complex |
| WP:WP4534 | 0.00137286558226 | 0.5 | CTNNA1 CTNNB1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| REAC:R-HSA-5218920 | 0.00326103241616 | 0.5 | CTNNA1 CTNNB1 | VEGFR2 mediated vascular permeability |
| REAC:R-HSA-5626467 | 0.00379215175563 | 0.5 | CTNNA1 CTNNB1 | RHO GTPases activate IQGAPs |
| KEGG:05200 | 0.00437599198048 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | Pathways in cancer |
| GO:0051149 | 0.00480126971785 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | positive regulation of muscle cell differentiation |
| WP:WP4540 | 0.00623747495525 | 0.5 | CTNNB1 CDH10 | Pathways Regulating Hippo Signaling |
| GO:0045296 | 0.0101996106268 | 1.0 | CTNNA1 CDH10 CTNNB1 CTNNA2 | cadherin binding |
| WP:WP2858 | 0.0132924049077 | 0.5 | CTNNB1 CTNNA2 | Ectoderm Differentiation |
| CORUM:6680 | 0.0249595281251 | 0.25 | CTNNB1 | CTNNB1-GLIS2 complex |
| GO:0071680 | 0.0270421395626 | 0.5 | CTNNA1 CTNNB1 | response to indole-3-methanol |
| GO:0071681 | 0.0270421395626 | 0.5 | CTNNA1 CTNNB1 | cellular response to indole-3-methanol |
| GO:0051147 | 0.0320435644688 | 0.75 | CTNNA1 CTNNB1 CTNNA2 | regulation of muscle cell differentiation |
| GO:0050839 | 0.0382716890733 | 1.0 | CTNNA1 CDH10 CTNNB1 CTNNA2 | cell adhesion molecule binding |
| WP:WP3888 | 0.0393304030404 | 0.5 | CTNNA1 CTNNB1 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-4420097 | 0.0408500448467 | 0.5 | CTNNA1 CTNNB1 | VEGFA-VEGFR2 Pathway |
| GO:0005912 | 0.0433740392707 | 1.0 | CTNNA1 CDH10 CTNNB1 CTNNA2 | adherens junction |
| GO:0070161 | 0.0477280075644 | 1.0 | CTNNA1 CDH10 CTNNB1 CTNNA2 | anchoring junction |
| REAC:R-HSA-194138 | 0.0483568152087 | 0.5 | CTNNA1 CTNNB1 | Signaling by VEGF |
| CORUM:6334 | 0.0499140284799 | 0.25 | CTNNB1 | Afadin-beta-catenin complex |
| CORUM:6359 | 0.0499140284799 | 0.25 | CTNNB1 | RHAMM-beta-catenin complex |
| CORUM:6364 | 0.0499140284799 | 0.25 | CTNNB1 | OVOL2-beta-catenin-TCF4 complex |
| CORUM:6269 | 0.0499140284799 | 0.25 | CTNNB1 | DLL1-CTNNB1-CDH2 complex |
| CORUM:6961 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNB1-GID8 complex |
| CORUM:7312 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNB1-ESR1 complex |
| CORUM:5281 | 0.0499140284799 | 0.25 | CTNNB1 | Cell-cell junction complex (CDH1-CTNNB1) |
| CORUM:5274 | 0.0499140284799 | 0.25 | CTNNA1 | Cell-cell junction complex (ARHGAP10-CTNNA1) |
| CORUM:5262 | 0.0499140284799 | 0.25 | CTNNB1 | TCF4-CTNNB1 complex |
| CORUM:4095 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNAL1-CTNNB1 complex |
| CORUM:3155 | 0.0499140284799 | 0.25 | CTNNB1 | TFC4-CTNNB1 complex |
| CORUM:6336 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNB1-DNMT1 complex |
| CORUM:6339 | 0.0499140284799 | 0.25 | CTNNB1 | beta-catenin-B-cell lymphoma 9 protein complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CTNNA1 | CTNNA2 | 0.632 | 0.681 | bioplex_WMM fraction |
| CTNNB1 | CTNNA1 | 0.25 | 0.474 | hein_WMM bioplex_WMM Guru boldt hein (CTNNB1) gupta_WMM fraction boldt_WMM treiber_WMM |
| CTNNB1 | CDH10 | 0.232 | 0.47 | hein_WMM bioplex_WMM hein (CTNNB1) |
| CTNNB1 | CTNNA2 | 0.009 | 0.109 | bioplex_WMM Guru fraction |
| CTNNA1 | CDH10 | 0.009 | 0.092 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00343 has an average edge precision of 0.365 which is ranked 3690 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTNNB1 | HuMAP2_00343 HuMAP2_01868 HuMAP2_02943 HuMAP2_05814 |
| CTNNA2 | HuMAP2_00343 HuMAP2_01868 HuMAP2_06526 |
| CTNNA1 | HuMAP2_00343 HuMAP2_01868 HuMAP2_02943 HuMAP2_06526 |
| CDH10 | HuMAP2_00343 HuMAP2_00625 HuMAP2_02943 |