hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00347
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBOX5 | RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5) | UniProt NCBI |
| TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) | UniProt NCBI |
| TAX1BP1 | Tax1-binding protein 1 (TRAF6-binding protein) | UniProt NCBI |
| CEP57 | Centrosomal protein of 57 kDa (Cep57) (FGF2-interacting protein) (Testis-specific protein 57) (Translokin) | UniProt NCBI |
| EMILIN1 | EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) | UniProt NCBI |
| MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) | UniProt NCBI |
| TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) | UniProt NCBI |
| TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) | UniProt NCBI |
| PPFIA3 | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5268 | 1.77634479162e-10 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TNF-alpha/NF-kappa B signaling complex 7 |
| REAC:R-HSA-937042 | 2.56759639518e-09 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | IRAK2 mediated activation of TAK1 complex |
| REAC:R-HSA-75893 | 2.68477408139e-09 | 0.555555555556 | TAB2 TAB3 TAX1BP1 TAB1 MAP3K7 | TNF signaling |
| REAC:R-HSA-9014325 | 4.03371015037e-09 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| CORUM:2758 | 6.30476064954e-09 | 0.333333333333 | TAB2 MAP3K7 TAB1 | TAK1 complex |
| REAC:R-HSA-975163 | 1.2225725792e-08 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| REAC:R-HSA-937072 | 1.2225725792e-08 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| REAC:R-HSA-450321 | 8.91499029266e-08 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| REAC:R-HSA-450302 | 1.07889289355e-07 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-5357956 | 2.88915534454e-07 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TNFR1-induced NFkappaB signaling pathway |
| REAC:R-HSA-445989 | 3.33274424099e-07 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| REAC:R-HSA-168638 | 6.35898309752e-07 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | NOD1/2 Signaling Pathway |
| WP:WP2637 | 7.70585326433e-07 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Structural Pathway of Interleukin 1 (IL-1) |
| WP:WP195 | 9.08387989523e-07 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | IL-1 signaling pathway |
| REAC:R-HSA-73887 | 9.77386993847e-07 | 0.555555555556 | TAB2 TAB3 TAX1BP1 TAB1 MAP3K7 | Death Receptor Signalling |
| CORUM:6344 | 2.85827866265e-06 | 0.333333333333 | TAB2 MAP3K7 TAB1 | TNF-R1-associated signaling complex |
| REAC:R-HSA-168643 | 3.53909458869e-06 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:04064 | 4.63271748137e-06 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | NF-kappa B signaling pathway |
| REAC:R-HSA-450294 | 7.1798681737e-06 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | MAP kinase activation |
| WP:WP75 | 8.3923449037e-06 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll-like Receptor Signaling Pathway |
| WP:WP231 | 8.3923449037e-06 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TNF alpha Signaling Pathway |
| KEGG:04668 | 8.96860597236e-06 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TNF signaling pathway |
| REAC:R-HSA-448424 | 1.04034613479e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Interleukin-17 signaling |
| REAC:R-HSA-2871837 | 1.5410306565e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | FCERI mediated NF-kB activation |
| REAC:R-HSA-168176 | 2.09746804746e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 2.09746804746e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 2.09746804746e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 2.31260502751e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| WP:WP3851 | 2.35896071746e-05 | 0.333333333333 | TAB2 MAP3K7 TAB1 | TLR4 Signaling and Tolerance |
| REAC:R-HSA-168181 | 2.42615347513e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 2.42615347513e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | MyD88 dependent cascade initiated on endosome |
| WP:WP1449 | 2.73950278181e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Regulation of toll-like receptor signaling pathway |
| REAC:R-HSA-168138 | 2.92246982613e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 2.92246982613e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 2.92246982613e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168164 | 3.05757392315e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-181438 | 3.34171946548e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 3.34171946548e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-5607764 | 3.34171946548e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-166166 | 3.49096734462e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 3.49096734462e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | TRIF(TICAM1)-mediated TLR4 signaling |
| WP:WP4329 | 3.67915356407e-05 | 0.333333333333 | TAB2 MAP3K7 TAB1 | miRNAs involvement in the immune response in sepsis |
| CORUM:5215 | 4.02261743042e-05 | 0.222222222222 | TAB2 TAB1 | CS-MAP3K7IP1-MAP3K7IP2 complex |
| REAC:R-HSA-9020702 | 4.13825173994e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Interleukin-1 signaling |
| GO:0002755 | 6.25321605858e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | MyD88-dependent toll-like receptor signaling pathway |
| KEGG:04621 | 7.54323546943e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | NOD-like receptor signaling pathway |
| GO:0070423 | 8.36518804488e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | nucleotide-binding oligomerization domain containing signaling pathway |
| REAC:R-HSA-166016 | 9.11348534984e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll Like Receptor 4 (TLR4) Cascade |
| GO:0035872 | 9.60189204298e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway |
| REAC:R-HSA-2454202 | 9.75039727383e-05 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-446652 | 0.000118612309892 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Interleukin-1 family signaling |
| REAC:R-HSA-5621481 | 0.000118612309892 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | C-type lectin receptors (CLRs) |
| KEGG:05130 | 0.000118681936928 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-168898 | 0.000180976381922 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Toll-like Receptor Cascades |
| WP:WP2018 | 0.000198940296053 | 0.333333333333 | TAB2 MAP3K7 TAB1 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| KEGG:05140 | 0.000224770487371 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Leishmaniasis |
| KEGG:04657 | 0.00041885134954 | 0.333333333333 | TAB2 MAP3K7 TAB3 | IL-17 signaling pathway |
| KEGG:04620 | 0.000779282816557 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Toll-like receptor signaling pathway |
| GO:0002753 | 0.000821491428283 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | cytoplasmic pattern recognition receptor signaling pathway |
| KEGG:05145 | 0.0010182253963 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Toxoplasmosis |
| KEGG:04380 | 0.00133973512852 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Osteoclast differentiation |
| KEGG:05135 | 0.00172190181766 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Yersinia infection |
| WP:WP4666 | 0.00435511396435 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Hepatitis B infection |
| KEGG:05161 | 0.00453889033858 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Hepatitis B |
| KEGG:05169 | 0.0074286719289 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Epstein-Barr virus infection |
| WP:WP4496 | 0.00782479344974 | 0.222222222222 | MAP3K7 TAB1 | Signal transduction through IL1R |
| KEGG:05170 | 0.00951877888355 | 0.333333333333 | TAB2 MAP3K7 TAB1 | Human immunodeficiency virus 1 infection |
| GO:0070498 | 0.00954888715776 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | interleukin-1-mediated signaling pathway |
| GO:0000187 | 0.0122267246852 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | activation of MAPK activity |
| GO:0038095 | 0.0127223411758 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Fc-epsilon receptor signaling pathway |
| GO:0002223 | 0.0127223411758 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | stimulatory C-type lectin receptor signaling pathway |
| GO:0002220 | 0.0132328037428 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | innate immune response activating cell surface receptor signaling pathway |
| WP:WP382 | 0.0147748088741 | 0.333333333333 | TAB2 MAP3K7 TAB1 | MAPK Signaling Pathway |
| REAC:R-HSA-168249 | 0.0160414992365 | 0.555555555556 | TAB2 TAB3 TAX1BP1 TAB1 MAP3K7 | Innate Immune System |
| KEGG:04010 | 0.0199835466862 | 0.333333333333 | TAB2 MAP3K7 TAB1 | MAPK signaling pathway |
| GO:0002224 | 0.0213554237042 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | toll-like receptor signaling pathway |
| GO:0051090 | 0.0226128455423 | 0.555555555556 | TAB2 TAB3 TAX1BP1 TAB1 MAP3K7 | regulation of DNA-binding transcription factor activity |
| GO:0051092 | 0.0228748482281 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | positive regulation of NF-kappaB transcription factor activity |
| HP:0001682 | 0.0235719846951 | 0.222222222222 | TAB2 CEP57 | Subvalvular aortic stenosis |
| HP:0011103 | 0.026930967926 | 0.222222222222 | TAB2 CEP57 | Abnormal left ventricular outflow tract morphology |
| REAC:R-HSA-449147 | 0.029733118853 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | Signaling by Interleukins |
| REAC:R-HSA-168256 | 0.0324601785032 | 0.666666666667 | TAB2 TAX1BP1 UBOX5 TAB3 TAB1 MAP3K7 | Immune System |
| GO:0071347 | 0.0348035698233 | 0.444444444444 | TAB2 MAP3K7 TAB1 TAB3 | cellular response to interleukin-1 |
| CORUM:748 | 0.0499262710315 | 0.111111111111 | MAP3K7 | TRAF6-TAK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EMILIN1 | PPFIA3 | 0.492 | 0.619 | bioplex (EMILIN1) bioplex_WMM |
| TAB3 | EMILIN1 | 0.461 | 0.6 | bioplex (EMILIN1) bioplex_WMM |
| TAB2 | EMILIN1 | 0.436 | 0.58 | bioplex (EMILIN1) bioplex_WMM |
| UBOX5 | EMILIN1 | 0.329 | 0.519 | bioplex (EMILIN1) bioplex_WMM |
| EMILIN1 | TAX1BP1 | 0.234 | 0.471 | bioplex (EMILIN1) bioplex_WMM |
| EMILIN1 | MAP3K7 | 0.088 | 0.353 | bioplex (EMILIN1) bioplex_WMM |
| EMILIN1 | TAB1 | 0.055 | 0.308 | bioplex (EMILIN1) bioplex_WMM |
| EMILIN1 | CEP57 | 0.037 | 0.266 | bioplex (EMILIN1) bioplex_WMM |
| TAB1 | MAP3K7 | 0.021 | 0.188 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| TAB2 | TAB1 | 0.014 | 0.137 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TAB2 | MAP3K7 | 0.014 | 0.137 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| UBOX5 | TAB3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| UBOX5 | CEP57 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| TAB3 | CEP57 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| TAB3 | PPFIA3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| UBOX5 | PPFIA3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| TAB3 | TAB2 | 0.008 | 0.086 | bioplex_WMM youn_WMM WMM_only |
| TAB3 | MAP3K7 | 0.008 | 0.065 | bioplex_WMM youn_WMM WMM_only |
| UBOX5 | TAB2 | 0.008 | 0.065 | bioplex_WMM WMM_only |
| CEP57 | PPFIA3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| TAB3 | TAB1 | 0.008 | 0.033 | bioplex_WMM youn_WMM WMM_only |
| UBOX5 | MAP3K7 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| TAB3 | TAX1BP1 | 0.008 | 0.031 | bioplex_WMM WMM_only |
| UBOX5 | TAX1BP1 | 0.008 | 0.031 | bioplex_WMM WMM_only |
| TAB2 | CEP57 | 0.008 | 0.019 | bioplex_WMM youn_WMM WMM_only |
| TAB2 | PPFIA3 | 0.008 | 0.016 | bioplex_WMM WMM_only |
| UBOX5 | TAB1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CEP57 | MAP3K7 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| MAP3K7 | PPFIA3 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| TAX1BP1 | PPFIA3 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| CEP57 | TAX1BP1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| TAB1 | CEP57 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| TAB1 | PPFIA3 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| TAB2 | TAX1BP1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| TAX1BP1 | MAP3K7 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| TAB1 | TAX1BP1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00347 has an average edge precision of 0.142 which is ranked 6759 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UBOX5 | HuMAP2_00142 HuMAP2_00347 |
| TAB2 | HuMAP2_00142 HuMAP2_00347 HuMAP2_04881 |
| TAX1BP1 | HuMAP2_00347 HuMAP2_00623 HuMAP2_06282 |
| CEP57 | HuMAP2_00330 HuMAP2_00347 HuMAP2_03975 HuMAP2_05567 HuMAP2_05749 HuMAP2_05751 HuMAP2_06345 |
| EMILIN1 | HuMAP2_00142 HuMAP2_00347 |
| MAP3K7 | HuMAP2_00347 HuMAP2_04653 |
| TAB3 | HuMAP2_00142 HuMAP2_00347 |
| TAB1 | HuMAP2_00142 HuMAP2_00347 HuMAP2_01481 HuMAP2_04653 |
| PPFIA3 | HuMAP2_00347 HuMAP2_03605 HuMAP2_03962 HuMAP2_05013 HuMAP2_05428 HuMAP2_06343 |