hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00359
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRPF4B | Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog) | UniProt NCBI |
| MTREX | Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) | UniProt NCBI |
| NCBP2 | Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) | UniProt NCBI |
| SRRT | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2) | UniProt NCBI |
| ZC3H18 | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:351 | 2.76221697912e-06 | 0.8 | MTREX NCBP2 SRRT PRPF4B | Spliceosome |
| REAC:R-HSA-72163 | 0.00246885319177 | 0.6 | NCBP2 SRRT MTREX | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00281668881241 | 0.6 | NCBP2 SRRT MTREX | mRNA Splicing |
| REAC:R-HSA-72203 | 0.00567167369058 | 0.6 | NCBP2 SRRT MTREX | Processing of Capped Intron-Containing Pre-mRNA |
| HPA:009020_13 | 0.0136400669622 | 0.6 | NCBP2 SRRT MTREX | cervix, uterine; squamous epithelial cells[Supported,High] |
| HPA:009010_13 | 0.0174086151451 | 0.6 | NCBP2 SRRT MTREX | cervix, uterine; glandular cells[Supported,High] |
| CORUM:1181 | 0.0199413185249 | 0.4 | PRPF4B MTREX | C complex spliceosome |
| HPA:044010_13 | 0.0234185559543 | 0.6 | NCBP2 SRRT MTREX | skin 2; epidermal cells[Supported,High] |
| HPA:039010_13 | 0.0236024900229 | 0.6 | NCBP2 SRRT MTREX | salivary gland; glandular cells[Supported,High] |
| WP:WP411 | 0.0254557044772 | 0.4 | NCBP2 PRPF4B | mRNA Processing |
| HPA:003010_13 | 0.0280991888292 | 0.6 | NCBP2 SRRT MTREX | bone marrow; hematopoietic cells[Supported,High] |
| HPA:016010_13 | 0.0293581469203 | 0.6 | NCBP2 SRRT MTREX | esophagus; squamous epithelial cells[Supported,High] |
| HPA:024020_13 | 0.0319860664233 | 0.6 | NCBP2 SRRT MTREX | kidney; cells in tubules[Supported,High] |
| REAC:R-HSA-6807505 | 0.0361060371214 | 0.4 | NCBP2 SRRT | RNA polymerase II transcribes snRNA genes |
| HPA:009020_03 | 0.0397374089383 | 0.6 | NCBP2 SRRT MTREX | cervix, uterine; squamous epithelial cells[Uncertain,High] |
| HPA:055010_13 | 0.0397374089383 | 0.6 | NCBP2 SRRT MTREX | thyroid gland; glandular cells[Supported,High] |
| HPA:053020_13 | 0.0399976212256 | 0.6 | NCBP2 SRRT MTREX | testis; cells in seminiferous ducts[Supported,High] |
| HPA:057010_13 | 0.0437586981176 | 0.6 | NCBP2 SRRT MTREX | urinary bladder; urothelial cells[Supported,High] |
| HPA:008010_12 | 0.0437586981176 | 0.6 | NCBP2 SRRT MTREX | cerebral cortex; endothelial cells[Supported,Medium] |
| HPA:001040_13 | 0.0437586981176 | 0.6 | NCBP2 SRRT MTREX | adrenal gland; glandular cells[Supported,High] |
| GO:0000398 | 0.0464577202339 | 0.8 | MTREX NCBP2 SRRT PRPF4B | mRNA splicing, via spliceosome |
| GO:0000377 | 0.0464577202339 | 0.8 | MTREX NCBP2 SRRT PRPF4B | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| HPA:032010_13 | 0.0468711310654 | 0.6 | NCBP2 SRRT MTREX | pancreas; exocrine glandular cells[Supported,High] |
| GO:0000375 | 0.0482714880996 | 0.8 | MTREX NCBP2 SRRT PRPF4B | RNA splicing, via transesterification reactions |
| HPA:029010_13 | 0.0489253257786 | 0.6 | NCBP2 SRRT MTREX | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0492235080566 | 0.6 | NCBP2 SRRT MTREX | bronchus; respiratory epithelial cells[Supported,High] |
| CORUM:775 | 0.0499494897235 | 0.2 | NCBP2 | CBC complex (cap binding complex) |
| CORUM:1172 | 0.0499494897235 | 0.2 | NCBP2 | CBC complex (cap binding complex) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NCBP2 | MTREX | 0.968 | 0.88 | hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2) fraction |
| SRRT | NCBP2 | 0.959 | 0.863 | hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2) |
| ZC3H18 | NCBP2 | 0.929 | 0.846 | hein_WMM youn (NCBP2) bioplex (ZC3H18) bioplex_WMM Guru youn_WMM hein (NCBP2) fraction |
| NCBP2 | PRPF4B | 0.749 | 0.742 | hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2) |
| SRRT | ZC3H18 | 0.46 | 0.598 | hein_WMM bioplex (ZC3H18) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| ZC3H18 | PRPF4B | 0.109 | 0.376 | hein_WMM bioplex (ZC3H18) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
| ZC3H18 | MTREX | 0.01 | 0.132 | hein_WMM bioplex (ZC3H18) bioplex_WMM youn_WMM gupta_WMM |
| SRRT | PRPF4B | 0.009 | 0.094 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| PRPF4B | MTREX | 0.006 | 0.007 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SRRT | MTREX | 0.0 | 0.01 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_00359 has an average edge precision of 0.455 which is ranked 2843 out of all 6965 complexes.
Related Complexes