hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00369
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUDT5 | ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) | UniProt NCBI |
| SKA1 | Spindle and kinetochore-associated protein 1 | UniProt NCBI |
| SARS2 | Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | UniProt NCBI |
| PYCR3 | Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein) | UniProt NCBI |
| KLHDC10 | Kelch domain-containing protein 10 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 2.33456820519e-06 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | Glutamate and glutamine metabolism |
| GO:0004735 | 1.27120391093e-05 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 1.27120391093e-05 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | L-proline biosynthetic process |
| GO:0006561 | 3.17736949706e-05 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | proline biosynthetic process |
| KEGG:00330 | 5.71082541759e-05 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | Arginine and proline metabolism |
| KEGG:01230 | 0.000187840964122 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | Biosynthesis of amino acids |
| GO:0006560 | 0.000380900357231 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | proline metabolic process |
| GO:0009084 | 0.00115446662879 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | glutamine family amino acid biosynthetic process |
| WP:WP497 | 0.00210605462929 | 0.285714285714 | PYCR1 PYCR3 | Urea cycle and metabolism of amino groups |
| GO:0016646 | 0.00215539204286 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor |
| GO:0016645 | 0.00727854676446 | 0.428571428571 | PYCR1 PYCR2 PYCR3 | oxidoreductase activity, acting on the CH-NH group of donors |
| WP:WP4290 | 0.00859430044807 | 0.285714285714 | PYCR1 PYCR2 | Metabolic reprogramming in colon cancer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.949 | hein_WMM bioplex (PYCR1,PYCR2) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT5 | PYCR2 | 0.992 | 0.912 | bioplex (PYCR2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NUDT5 | PYCR1 | 0.971 | 0.882 | bioplex (PYCR1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| PYCR3 | PYCR1 | 0.251 | 0.475 | bioplex (PYCR1) bioplex_WMM boldt youn_WMM boldt_WMM |
| PYCR3 | PYCR2 | 0.11 | 0.379 | bioplex (PYCR2) bioplex_WMM youn_WMM |
| PYCR2 | SKA1 | 0.059 | 0.333 | bioplex (PYCR2) bioplex_WMM youn_WMM gupta_WMM |
| PYCR1 | KLHDC10 | 0.037 | 0.265 | bioplex (PYCR1) bioplex_WMM |
| NUDT5 | SKA1 | 0.034 | 0.26 | hein_WMM bioplex_WMM youn_WMM hein (SKA1) gupta_WMM |
| PYCR1 | SARS2 | 0.033 | 0.254 | bioplex_WMM youn_WMM fraction |
| PYCR2 | SARS2 | 0.009 | 0.096 | bioplex_WMM youn_WMM gupta_WMM fraction |
| NUDT5 | KLHDC10 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| NUDT5 | PYCR3 | 0.008 | 0.033 | bioplex_WMM youn_WMM WMM_only |
| PYCR2 | KLHDC10 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| SKA1 | SARS2 | 0.007 | 0.002 | youn_WMM gupta_WMM WMM_only |
| NUDT5 | SARS2 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
| PYCR3 | KLHDC10 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| PYCR1 | SKA1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PYCR3 | SKA1 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| PYCR3 | SARS2 | 0.003 | 0.014 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_00369 has an average edge precision of 0.262 which is ranked 5193 out of all 6965 complexes.
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