hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00374
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SETD2 | Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.43) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP) | UniProt NCBI |
| SCAF8 | SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16) | UniProt NCBI |
| CPSF4 | Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) | UniProt NCBI |
| FIP1L1 | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | UniProt NCBI |
| CPSF2 | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | UniProt NCBI |
| KLK6 | Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme) | UniProt NCBI |
| WDR33 | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | UniProt NCBI |
| CPSF1 | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | UniProt NCBI |
| CPSF3 | Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1144 | 8.53043734036e-16 | 0.555555555556 | CPSF3 CPSF1 CPSF2 CPSF4 FIP1L1 | Cleavage and polyadenylation factor (CPSF) |
| GO:0005849 | 2.81157896746e-15 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | mRNA cleavage factor complex |
| REAC:R-HSA-77595 | 2.99077451557e-14 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Processing of Intronless Pre-mRNAs |
| GO:0006369 | 3.74512784636e-13 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | termination of RNA polymerase II transcription |
| REAC:R-HSA-75067 | 4.14636766617e-13 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Processing of Capped Intronless Pre-mRNA |
| GO:0005847 | 2.21679144479e-12 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | mRNA cleavage and polyadenylation specificity factor complex |
| REAC:R-HSA-159231 | 2.55465677902e-12 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 3.03313006004e-12 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-72187 | 2.82975378725e-11 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 7.43285481803e-11 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | RNA Polymerase II Transcription Termination |
| GO:0006353 | 9.03387421086e-11 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | DNA-templated transcription, termination |
| KEGG:03015 | 1.51647608583e-10 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | mRNA surveillance pathway |
| REAC:R-HSA-72202 | 2.58738494576e-10 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Transport of Mature Transcript to Cytoplasm |
| GO:0031124 | 5.24023196712e-10 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | mRNA 3'-end processing |
| GO:0071427 | 1.43997958758e-09 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | mRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0006406 | 1.43997958758e-09 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | mRNA export from nucleus |
| GO:0051028 | 1.99941099403e-09 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | mRNA transport |
| GO:0071426 | 3.69244429764e-09 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | ribonucleoprotein complex export from nucleus |
| GO:0071166 | 3.91480088245e-09 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | ribonucleoprotein complex localization |
| GO:0006405 | 6.1454064317e-09 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | RNA export from nucleus |
| GO:0031123 | 7.22507601688e-09 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | RNA 3'-end processing |
| GO:0050657 | 1.61589955315e-08 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | nucleic acid transport |
| GO:0050658 | 1.61589955315e-08 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | RNA transport |
| GO:0051236 | 1.86075212896e-08 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | establishment of RNA localization |
| GO:0006611 | 2.33954431519e-08 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | protein export from nucleus |
| GO:0051168 | 3.93768979374e-08 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | nuclear export |
| REAC:R-HSA-72163 | 4.35030872703e-08 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | mRNA Splicing - Major Pathway |
| GO:0015931 | 4.45883752586e-08 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | nucleobase-containing compound transport |
| REAC:R-HSA-72172 | 5.67646923533e-08 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | mRNA Splicing |
| GO:0006403 | 7.45753454688e-08 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | RNA localization |
| CORUM:1147 | 2.20399991956e-07 | 0.333333333333 | CPSF1 CPSF2 CPSF3 | Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3) |
| REAC:R-HSA-72203 | 2.32875887239e-07 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0031503 | 3.25115875236e-07 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | protein-containing complex localization |
| GO:0006378 | 6.73878294428e-07 | 0.555555555556 | SCAF8 CPSF1 CPSF3 WDR33 FIP1L1 | mRNA polyadenylation |
| GO:0043631 | 8.70794256443e-07 | 0.555555555556 | SCAF8 CPSF1 CPSF3 WDR33 FIP1L1 | RNA polyadenylation |
| GO:0006913 | 9.86309878033e-07 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | nucleocytoplasmic transport |
| GO:0051169 | 1.06679808822e-06 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | nuclear transport |
| GO:0006379 | 9.37062910447e-06 | 0.444444444444 | CPSF3 CPSF1 CPSF4 FIP1L1 | mRNA cleavage |
| GO:0006397 | 1.58765085867e-05 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | mRNA processing |
| WP:WP411 | 3.45321495109e-05 | 0.444444444444 | CPSF1 CPSF2 CPSF4 CPSF3 | mRNA Processing |
| REAC:R-HSA-8953854 | 0.000102817629694 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Metabolism of RNA |
| GO:0000377 | 0.000320916780497 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000320916780497 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000339860325549 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | RNA splicing, via transesterification reactions |
| GO:0090501 | 0.00059107223237 | 0.444444444444 | CPSF3 CPSF1 CPSF4 FIP1L1 | RNA phosphodiester bond hydrolysis |
| GO:0008380 | 0.000890330753188 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | RNA splicing |
| GO:0016071 | 0.000926406488347 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | mRNA metabolic process |
| GO:0006396 | 0.00160817529083 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | RNA processing |
| GO:0098789 | 0.00167376753379 | 0.333333333333 | CPSF1 CPSF4 FIP1L1 | pre-mRNA cleavage required for polyadenylation |
| GO:0098787 | 0.00217524004777 | 0.333333333333 | CPSF1 CPSF4 FIP1L1 | mRNA cleavage involved in mRNA processing |
| REAC:R-HSA-73857 | 0.00289990133995 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | RNA Polymerase II Transcription |
| GO:0006886 | 0.00537320209692 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 SETD2 WDR33 CPSF4 CPSF3 | intracellular protein transport |
| GO:0044451 | 0.00537320209692 | 0.777777777778 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 SCAF8 CPSF3 | nucleoplasm part |
| REAC:R-HSA-74160 | 0.00545442724115 | 0.666666666667 | CPSF2 FIP1L1 CPSF1 WDR33 CPSF4 CPSF3 | Gene expression (Transcription) |
| GO:0006366 | 0.00553073226606 | 0.888888888889 | CPSF2 FIP1L1 CPSF1 WDR33 SETD2 CPSF4 SCAF8 CPSF3 | transcription by RNA polymerase II |
| GO:0090305 | 0.0317143436917 | 0.444444444444 | CPSF3 CPSF1 CPSF4 FIP1L1 | nucleic acid phosphodiester bond hydrolysis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CPSF1 | FIP1L1 | 1.0 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM youn_WMM hein (FIP1L1) Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF1 | 1.0 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| CPSF3 | CPSF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| FIP1L1 | CPSF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (FIP1L1) Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF4 | 1.0 | 0.949 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| CPSF1 | CPSF3 | 0.999 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM Guru youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| FIP1L1 | CPSF4 | 0.999 | 0.949 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM hein (FIP1L1) gupta_WMM treiber_WMM |
| CPSF1 | CPSF2 | 0.999 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF3 | 0.999 | 0.947 | hein_WMM bioplex_WMM Guru youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| CPSF4 | CPSF2 | 0.995 | 0.924 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| CPSF1 | CPSF4 | 0.988 | 0.901 | hein_WMM youn (CPSF1) bioplex (CPSF4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| WDR33 | CPSF2 | 0.974 | 0.886 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR33 | FIP1L1 | 0.969 | 0.88 | hein_WMM bioplex_WMM youn_WMM hein (FIP1L1) gupta_WMM treiber_WMM |
| CPSF3 | CPSF4 | 0.469 | 0.605 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM hein (CPSF3) gupta_WMM |
| FIP1L1 | CPSF3 | 0.141 | 0.405 | hein_WMM bioplex_WMM youn_WMM hein (CPSF3,FIP1L1) gupta_WMM treiber_WMM |
| CPSF4 | KLK6 | 0.041 | 0.269 | bioplex (CPSF4) bioplex_WMM |
| WDR33 | SETD2 | 0.023 | 0.209 | bioplex_WMM youn_WMM fraction |
| WDR33 | SCAF8 | 0.022 | 0.199 | bioplex_WMM youn_WMM fraction |
| CPSF1 | SCAF8 | 0.008 | 0.095 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| FIP1L1 | SETD2 | 0.008 | 0.025 | bioplex_WMM youn_WMM WMM_only |
| FIP1L1 | SCAF8 | 0.008 | 0.014 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CPSF2 | SCAF8 | 0.007 | 0.007 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| WDR33 | KLK6 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| SCAF8 | SETD2 | 0.007 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| CPSF1 | KLK6 | 0.007 | 0.01 | bioplex (KLK6) bioplex_WMM |
| CPSF2 | SETD2 | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only |
| CPSF1 | SETD2 | 0.007 | 0.007 | youn (CPSF1) bioplex_WMM youn_WMM |
| CPSF3 | SETD2 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CPSF4 | SETD2 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CPSF3 | SCAF8 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CPSF3 | KLK6 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| FIP1L1 | KLK6 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| CPSF2 | KLK6 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| CPSF4 | SCAF8 | 0.004 | 0.009 | bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_00374 has an average edge precision of 0.413 which is ranked 3173 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SETD2 | HuMAP2_00374 HuMAP2_03898 HuMAP2_05059 HuMAP2_05568 |
| SCAF8 | HuMAP2_00374 HuMAP2_00529 HuMAP2_05059 HuMAP2_05881 |
| CPSF4 | HuMAP2_00220 HuMAP2_00374 HuMAP2_03166 HuMAP2_04008 HuMAP2_06540 |
| FIP1L1 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |
| CPSF2 | HuMAP2_00220 HuMAP2_00374 HuMAP2_02763 HuMAP2_06540 |
| KLK6 | HuMAP2_00220 HuMAP2_00374 HuMAP2_03166 HuMAP2_04008 |
| WDR33 | HuMAP2_00220 HuMAP2_00374 HuMAP2_05059 HuMAP2_06540 |
| CPSF1 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |
| CPSF3 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |