hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00377
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BAZ1A | Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) | UniProt NCBI |
| CAPN6 | Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM) | UniProt NCBI |
| POLE2 | DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) | UniProt NCBI |
| POLE | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) | UniProt NCBI |
| POLE3 | DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | UniProt NCBI |
| CHRAC1 | Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15) | UniProt NCBI |
| POLE4 | DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008622 | 1.72030486364e-13 | 0.714285714286 | CHRAC1 POLE4 POLE3 POLE POLE2 | epsilon DNA polymerase complex |
| REAC:R-HSA-68952 | 1.99767882788e-10 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA replication initiation |
| REAC:R-HSA-174430 | 1.99767882788e-10 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Telomere C-strand synthesis initiation |
| GO:0042575 | 7.50504170437e-10 | 0.714285714286 | CHRAC1 POLE4 POLE3 POLE POLE2 | DNA polymerase complex |
| CORUM:1108 | 1.23769432954e-09 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 2.15733512906e-09 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 2.15733512906e-09 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA synthesome complex (17 subunits) |
| GO:0003887 | 4.52163386318e-09 | 0.714285714286 | CHRAC1 POLE4 POLE3 POLE POLE2 | DNA-directed DNA polymerase activity |
| CORUM:234 | 1.3523445861e-08 | 0.428571428571 | BAZ1A CHRAC1 POLE3 | HuCHRAC complex |
| GO:0034061 | 1.68636544732e-08 | 0.714285714286 | CHRAC1 POLE4 POLE3 POLE POLE2 | DNA polymerase activity |
| REAC:R-HSA-5651801 | 1.70443817949e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-174417 | 3.02466099648e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03410 | 3.20397186318e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Base excision repair |
| REAC:R-HSA-5696397 | 3.60020594638e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 3.60020594638e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 5.24494259186e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA replication |
| REAC:R-HSA-110314 | 7.7932067567e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 7.7932067567e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 8.94631183986e-08 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Termination of translesion DNA synthesis |
| REAC:R-HSA-68962 | 1.16308570792e-07 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Activation of the pre-replicative complex |
| KEGG:03420 | 1.20717598349e-07 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Nucleotide excision repair |
| REAC:R-HSA-73933 | 1.48776903705e-07 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 2.09638069879e-07 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 2.87472269464e-07 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Dual Incision in GG-NER |
| REAC:R-HSA-73893 | 5.05829239998e-07 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA Damage Bypass |
| WP:WP4022 | 1.3483595963e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Pyrimidine metabolism |
| REAC:R-HSA-6782210 | 1.7969334739e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 1.91445563709e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6782135 | 1.91445563709e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 4.02500875924e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 4.69237324132e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Telomere Maintenance |
| REAC:R-HSA-5696399 | 5.4392781937e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-69002 | 5.70696087866e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-73884 | 6.27176934945e-06 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Base Excision Repair |
| GO:0032201 | 1.49294898514e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-73886 | 1.50487341812e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 1.62062768489e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 2.15138012589e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Synthesis of DNA |
| GO:0016779 | 2.1787412443e-05 | 0.714285714286 | CHRAC1 POLE4 POLE3 POLE POLE2 | nucleotidyltransferase activity |
| GO:0006270 | 2.33016882025e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA replication initiation |
| REAC:R-HSA-69306 | 2.80244760686e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA Replication |
| REAC:R-HSA-5693567 | 3.17830201784e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-69206 | 3.17830201784e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | G1/S Transition |
| REAC:R-HSA-5693538 | 3.81113924647e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Homology Directed Repair |
| GO:0006261 | 4.31404158736e-05 | 0.714285714286 | POLE3 BAZ1A POLE2 POLE POLE4 | DNA-dependent DNA replication |
| REAC:R-HSA-453279 | 5.2101603701e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 7.13974352246e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | S Phase |
| REAC:R-HSA-5693532 | 8.083952191e-05 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA Double-Strand Break Repair |
| GO:0140097 | 0.000217910906533 | 0.714285714286 | CHRAC1 POLE4 POLE3 POLE POLE2 | catalytic activity, acting on DNA |
| GO:0033260 | 0.000229373391109 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | nuclear DNA replication |
| GO:0044786 | 0.000310987597034 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | cell cycle DNA replication |
| GO:0006260 | 0.00051973884636 | 0.714285714286 | POLE3 BAZ1A POLE2 POLE POLE4 | DNA replication |
| GO:0061695 | 0.000737359830084 | 0.714285714286 | CHRAC1 POLE4 POLE3 POLE POLE2 | transferase complex, transferring phosphorus-containing groups |
| CORUM:6665 | 0.000914055366538 | 0.285714285714 | POLE4 POLE3 | ATAC complex, YEATS2-linked |
| REAC:R-HSA-73894 | 0.00117761416591 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | DNA Repair |
| REAC:R-HSA-69278 | 0.0076688970217 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Cell Cycle, Mitotic |
| WP:WP466 | 0.00859430044807 | 0.285714285714 | POLE2 POLE | DNA Replication |
| GO:0008623 | 0.00946729163895 | 0.285714285714 | BAZ1A CHRAC1 | CHRAC |
| REAC:R-HSA-1640170 | 0.0155446721983 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | Cell Cycle |
| GO:0000723 | 0.0168953290765 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | telomere maintenance |
| GO:0051276 | 0.0190987011465 | 0.857142857143 | POLE4 CHRAC1 POLE3 POLE POLE2 BAZ1A | chromosome organization |
| GO:0044454 | 0.0190987011465 | 0.857142857143 | POLE4 CHRAC1 POLE3 POLE POLE2 BAZ1A | nuclear chromosome part |
| WP:WP45 | 0.0194028583033 | 0.285714285714 | POLE2 POLE | G1 to S cell cycle control |
| GO:0000228 | 0.0223767814778 | 0.857142857143 | POLE4 CHRAC1 POLE3 POLE POLE2 BAZ1A | nuclear chromosome |
| GO:0032200 | 0.0235853115521 | 0.571428571429 | POLE4 POLE3 POLE POLE2 | telomere organization |
| WP:WP2446 | 0.0369669918209 | 0.285714285714 | POLE2 POLE | Retinoblastoma Gene in Cancer |
| WP:000000 | 0.0394625231882 | 1.0 | POLE4 CAPN6 CHRAC1 POLE3 POLE POLE2 BAZ1A | WIKIPATHWAYS |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | POLE4 CHRAC1 POLE3 POLE POLE2 BAZ1A | CORUM root |
| CORUM:94 | 0.0499886427319 | 0.142857142857 | BAZ1A | SNF2H-BAZ1A complex |
| CORUM:925 | 0.0499886427319 | 0.142857142857 | BAZ1A | SNF2H-BAZ1A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLE3 | CHRAC1 | 0.988 | 0.901 | bioplex_WMM Guru fraction |
| POLE3 | POLE4 | 0.951 | 0.858 | bioplex_WMM Guru Malo fraction |
| POLE | POLE4 | 0.311 | 0.504 | bioplex_WMM Malo fraction |
| POLE3 | POLE | 0.27 | 0.483 | bioplex_WMM Malo fraction |
| POLE | POLE2 | 0.216 | 0.464 | bioplex (POLE,POLE2) bioplex_WMM Malo fraction |
| BAZ1A | CHRAC1 | 0.064 | 0.349 | bioplex_WMM fraction |
| CAPN6 | BAZ1A | 0.063 | 0.348 | bioplex (CAPN6) bioplex_WMM |
| POLE2 | POLE4 | 0.045 | 0.285 | bioplex (POLE2) bioplex_WMM |
| POLE3 | BAZ1A | 0.027 | 0.227 | bioplex_WMM Guru fraction |
| POLE3 | POLE2 | 0.015 | 0.14 | bioplex (POLE2) bioplex_WMM |
| POLE | BAZ1A | 0.007 | 0.002 | youn_WMM WMM_only |
| CAPN6 | CHRAC1 | 0.007 | 0.007 | bioplex (CAPN6) bioplex_WMM |
| POLE3 | CAPN6 | 0.005 | 0.013 | bioplex (CAPN6) bioplex_WMM |
Images
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Complex HuMAP2_00377 has an average edge precision of 0.352 which is ranked 3906 out of all 6965 complexes.
Related Complexes