hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00382
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TCTN3 | Tectonic-3 | UniProt NCBI |
| PGRMC1 | Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) | UniProt NCBI |
| SSR1 | Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) | UniProt NCBI |
| ERP29 | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31) | UniProt NCBI |
| ERO1A | ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) | UniProt NCBI |
| TOR1AIP2 | Torsin-1A-interacting protein 2, isoform IFRG15 (15 kDa interferon-responsive protein) (IFRG15) | UniProt NCBI |
| EMD | Emerin | UniProt NCBI |
| VANGL1 | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) | UniProt NCBI |
| DHCR7 | 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Putative sterol reductase SR-2) (Sterol Delta(7)-reductase) | UniProt NCBI |
| SELENOF | Selenoprotein F (15 kDa selenoprotein) | UniProt NCBI |
| EBP | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein) | UniProt NCBI |
| TFRC | Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6807047 | 0.000861672784732 | 0.166666666667 | EBP DHCR7 | Cholesterol biosynthesis via desmosterol |
| REAC:R-HSA-6807062 | 0.000861672784732 | 0.166666666667 | EBP DHCR7 | Cholesterol biosynthesis via lathosterol |
| GO:0005783 | 0.00269698568838 | 0.75 | TOR1AIP2 EMD SELENOF ERP29 PGRMC1 SSR1 EBP DHCR7 ERO1A | endoplasmic reticulum |
| KEGG:00100 | 0.00365409462129 | 0.166666666667 | EBP DHCR7 | Steroid biosynthesis |
| KEGG:04141 | 0.0107159757517 | 0.25 | SSR1 ERP29 ERO1A | Protein processing in endoplasmic reticulum |
| HP:0003107 | 0.0168406410592 | 0.25 | EBP DHCR7 EMD | Abnormal circulating cholesterol concentration |
| HP:0002438 | 0.030977423621 | 0.333333333333 | VANGL1 TCTN3 DHCR7 EBP | Cerebellar malformation |
| REAC:R-HSA-191273 | 0.0392835928601 | 0.166666666667 | EBP DHCR7 | Cholesterol biosynthesis |
| HP:0001829 | 0.0448066771924 | 0.25 | EBP DHCR7 TCTN3 | Foot polydactyly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PGRMC1 | TCTN3 | 0.111 | 0.381 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) boldt gupta_WMM boldt_WMM |
| ERP29 | TCTN3 | 0.099 | 0.358 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) gupta_WMM |
| DHCR7 | TCTN3 | 0.069 | 0.349 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) gupta_WMM |
| SSR1 | TCTN3 | 0.061 | 0.339 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) gupta_WMM |
| EBP | TCTN3 | 0.046 | 0.293 | hein_WMM bioplex_WMM gupta (TCTN3) boldt gupta_WMM boldt_WMM |
| TCTN3 | EMD | 0.045 | 0.286 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) boldt gupta_WMM boldt_WMM |
| ERO1A | TCTN3 | 0.034 | 0.262 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) gupta_WMM |
| TCTN3 | TOR1AIP2 | 0.034 | 0.26 | bioplex (TOR1AIP2) bioplex_WMM gupta (TCTN3) gupta_WMM |
| SELENOF | TCTN3 | 0.032 | 0.24 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) gupta_WMM |
| VANGL1 | TCTN3 | 0.028 | 0.232 | hein_WMM bioplex_WMM gupta (TCTN3) hein (VANGL1) gupta_WMM |
| TCTN3 | TFRC | 0.027 | 0.227 | bioplex (TCTN3) bioplex_WMM gupta (TCTN3) gupta_WMM |
| ERO1A | ERP29 | 0.01 | 0.098 | bioplex (ERP29) bioplex_WMM gupta_WMM fraction |
| SSR1 | DHCR7 | 0.008 | 0.077 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SSR1 | EMD | 0.008 | 0.026 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DHCR7 | EBP | 0.008 | 0.011 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| VANGL1 | TOR1AIP2 | 0.007 | 0.01 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SELENOF | EMD | 0.007 | 0.009 | bioplex_WMM gupta_WMM WMM_only |
| SSR1 | TFRC | 0.007 | 0.006 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DHCR7 | TFRC | 0.007 | 0.011 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SELENOF | TFRC | 0.007 | 0.01 | bioplex_WMM gupta_WMM WMM_only |
| DHCR7 | SELENOF | 0.007 | 0.012 | bioplex_WMM gupta_WMM WMM_only |
| SSR1 | VANGL1 | 0.007 | 0.009 | youn_WMM gupta_WMM WMM_only |
| VANGL1 | DHCR7 | 0.007 | 0.007 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ERO1A | SELENOF | 0.007 | 0.007 | bioplex_WMM gupta_WMM WMM_only |
| VANGL1 | TFRC | 0.007 | 0.006 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TFRC | TOR1AIP2 | 0.007 | 0.007 | bioplex (TOR1AIP2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PGRMC1 | VANGL1 | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ERO1A | TFRC | 0.007 | 0.006 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| ERP29 | TFRC | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| PGRMC1 | TFRC | 0.007 | 0.005 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ERP29 | SELENOF | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| ERO1A | PGRMC1 | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| SSR1 | TOR1AIP2 | 0.007 | 0.005 | bioplex (TOR1AIP2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PGRMC1 | ERP29 | 0.007 | 0.005 | bioplex_WMM gupta_WMM WMM_only |
| VANGL1 | SELENOF | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
| DHCR7 | ERP29 | 0.007 | 0.004 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| EBP | TFRC | 0.007 | 0.003 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ERP29 | EMD | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only |
| ERO1A | DHCR7 | 0.007 | 0.003 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| ERO1A | EMD | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| ERO1A | TOR1AIP2 | 0.007 | 0.0 | bioplex_WMM gupta_WMM WMM_only |
| SELENOF | EBP | 0.007 | 0.0 | bioplex_WMM gupta_WMM WMM_only |
| VANGL1 | EBP | 0.007 | 0.0 | youn_WMM gupta_WMM WMM_only |
| ERP29 | TOR1AIP2 | 0.007 | 0.004 | bioplex_WMM gupta_WMM WMM_only |
| ERO1A | VANGL1 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
| ERO1A | SSR1 | 0.007 | 0.001 | gupta_WMM WMM_only |
| PGRMC1 | EMD | 0.007 | 0.003 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SSR1 | ERP29 | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| SSR1 | EBP | 0.007 | 0.001 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TFRC | EMD | 0.007 | 0.003 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PGRMC1 | SSR1 | 0.007 | 0.005 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ERP29 | EBP | 0.007 | 0.006 | bioplex (EBP) gupta_WMM |
| VANGL1 | EMD | 0.007 | 0.002 | bioplex (VANGL1) bioplex_WMM youn_WMM gupta_WMM |
| PGRMC1 | DHCR7 | 0.006 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| VANGL1 | ERP29 | 0.006 | 0.004 | bioplex (VANGL1) bioplex_WMM gupta_WMM |
| DHCR7 | EMD | 0.006 | 0.004 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| EBP | EMD | 0.006 | 0.006 | hein_WMM bioplex (EBP) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PGRMC1 | EBP | 0.006 | 0.003 | bioplex (EBP) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ERO1A | EBP | 0.006 | 0.005 | bioplex (EBP) bioplex_WMM gupta_WMM |
| TOR1AIP2 | EMD | 0.006 | 0.007 | bioplex (TOR1AIP2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DHCR7 | TOR1AIP2 | 0.006 | 0.005 | bioplex (TOR1AIP2) bioplex_WMM youn_WMM gupta_WMM |
| EBP | TOR1AIP2 | 0.006 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SSR1 | SELENOF | 0.005 | 0.012 | bioplex_WMM gupta_WMM WMM_only |
| PGRMC1 | SELENOF | 0.005 | 0.008 | bioplex_WMM gupta_WMM WMM_only |
| PGRMC1 | TOR1AIP2 | 0.004 | 0.01 | bioplex (TOR1AIP2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SELENOF | TOR1AIP2 | 0.004 | 0.016 | bioplex (TOR1AIP2) bioplex_WMM gupta_WMM |
Images
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Complex HuMAP2_00382 has an average edge precision of 0.056 which is ranked 6974 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TCTN3 | HuMAP2_00382 |
| PGRMC1 | HuMAP2_00382 HuMAP2_03081 HuMAP2_04685 HuMAP2_05852 |
| SSR1 | HuMAP2_00382 HuMAP2_01974 HuMAP2_02313 HuMAP2_03276 |
| ERP29 | HuMAP2_00382 HuMAP2_01860 |
| ERO1A | HuMAP2_00280 HuMAP2_00382 HuMAP2_02165 HuMAP2_02991 HuMAP2_06451 |
| TOR1AIP2 | HuMAP2_00382 HuMAP2_04937 |
| EMD | HuMAP2_00382 HuMAP2_06737 |
| VANGL1 | HuMAP2_00382 HuMAP2_03309 HuMAP2_06761 |
| DHCR7 | HuMAP2_00382 HuMAP2_02541 |
| SELENOF | HuMAP2_00382 HuMAP2_05818 |
| EBP | HuMAP2_00382 HuMAP2_05339 |
| TFRC | HuMAP2_00382 HuMAP2_01484 HuMAP2_05879 |