hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00383
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NSMCE3 | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | UniProt NCBI |
| NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27) | UniProt NCBI |
| SMC5 | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | UniProt NCBI |
| NSMCE4A | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | UniProt NCBI |
| NSMCE2 | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | UniProt NCBI |
| SMC6 | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030915 | 2.31084003444e-17 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | Smc5-Smc6 complex |
| GO:0106068 | 2.31084003444e-17 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | SUMO ligase complex |
| REAC:R-HSA-3108214 | 1.55014611982e-12 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-3108232 | 2.87080624572e-10 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 3.56389945589e-10 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | SUMOylation |
| GO:0000793 | 8.340685199e-09 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | condensed chromosome |
| REAC:R-HSA-597592 | 5.91578058515e-05 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | Post-translational protein modification |
| GO:0000722 | 0.000217734118711 | 0.5 | NSMCE2 SMC6 SMC5 | telomere maintenance via recombination |
| REAC:R-HSA-392499 | 0.000522475750064 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | Metabolism of proteins |
| GO:1990234 | 0.00052342955083 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | transferase complex |
| GO:0006259 | 0.000579923761468 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | DNA metabolic process |
| GO:0006974 | 0.000584852292019 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | cellular response to DNA damage stimulus |
| GO:0006312 | 0.00123252169378 | 0.5 | NSMCE2 SMC6 SMC5 | mitotic recombination |
| GO:0051984 | 0.00416378298645 | 0.5 | NSMCE2 SMC6 SMC5 | positive regulation of chromosome segregation |
| GO:0006281 | 0.00761654730624 | 0.833333333333 | NSMCE1 NSMCE2 SMC5 NSMCE4A NSMCE3 | DNA repair |
| GO:1902494 | 0.013185208462 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | catalytic complex |
| GO:0044427 | 0.0151552637177 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | chromosomal part |
| GO:0005694 | 0.0188325821521 | 1.0 | SMC5 NSMCE4A NSMCE2 SMC6 NSMCE1 NSMCE3 | chromosome |
| GO:0035061 | 0.020283420769 | 0.333333333333 | SMC6 SMC5 | interchromatin granule |
| GO:0006310 | 0.0255854514322 | 0.666666666667 | NSMCE1 NSMCE2 SMC6 SMC5 | DNA recombination |
| GO:0090398 | 0.0353486827187 | 0.5 | NSMCE2 SMC6 SMC5 | cellular senescence |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMC6 | NSMCE1 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM hein (SMC6) Malo fraction |
| NSMCE1 | SMC5 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM Malo fraction |
| NSMCE1 | NSMCE2 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM Malo fraction |
| NSMCE1 | NSMCE3 | 1.0 | 0.949 | hein_WMM bioplex (NSMCE1) bioplex_WMM Malo fraction |
| SMC6 | NSMCE3 | 0.999 | 0.948 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| SMC5 | NSMCE3 | 0.995 | 0.924 | hein_WMM bioplex_WMM Malo fraction |
| SMC6 | SMC5 | 0.991 | 0.911 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| SMC6 | NSMCE2 | 0.99 | 0.909 | hein_WMM bioplex_WMM hein (SMC6) Malo fraction |
| NSMCE3 | NSMCE2 | 0.966 | 0.875 | hein_WMM bioplex_WMM Malo fraction |
| NSMCE1 | NSMCE4A | 0.961 | 0.869 | hein_WMM bioplex (NSMCE1,NSMCE4A) bioplex_WMM |
| SMC5 | NSMCE2 | 0.886 | 0.817 | hein_WMM bioplex_WMM Malo fraction |
| NSMCE3 | NSMCE4A | 0.88 | 0.814 | hein_WMM bioplex (NSMCE4A) bioplex_WMM |
| SMC6 | NSMCE4A | 0.408 | 0.567 | hein_WMM bioplex (NSMCE4A) bioplex_WMM hein (SMC6) |
| NSMCE4A | NSMCE2 | 0.023 | 0.209 | hein_WMM bioplex (NSMCE4A) bioplex_WMM |
| SMC5 | NSMCE4A | 0.0 | 0.001 | hein_WMM bioplex (NSMCE4A) bioplex_WMM |
Images
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Complex HuMAP2_00383 has an average edge precision of 0.776 which is ranked 1013 out of all 6965 complexes.
Related Complexes