hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00388
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CEP131 | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) | UniProt NCBI |
| KIAA0753 | Protein moonraker (MNR) (OFD1- and FOPNL-interacting protein) | UniProt NCBI |
| PIBF1 | Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) | UniProt NCBI |
| OFD1 | Oral-facial-digital syndrome 1 protein (Protein 71-7A) | UniProt NCBI |
| SSX2IP | Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) | UniProt NCBI |
| CCDC138 | Coiled-coil domain-containing protein 138 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0034451 | 2.60849957036e-09 | 0.833333333333 | KIAA0753 CEP131 PIBF1 OFD1 SSX2IP | centriolar satellite |
| GO:0044450 | 2.42948199319e-05 | 0.833333333333 | KIAA0753 CEP131 PIBF1 OFD1 SSX2IP | microtubule organizing center part |
| CORUM:6441 | 2.51655344529e-05 | 0.333333333333 | KIAA0753 OFD1 | KIAA0753-FOR20-OFD1 complex |
| HP:0002876 | 9.03344198146e-05 | 0.5 | KIAA0753 OFD1 PIBF1 | Episodic tachypnea |
| HP:0002419 | 0.000120203751216 | 0.5 | KIAA0753 OFD1 PIBF1 | Molar tooth sign on MRI |
| WP:WP4536 | 0.000261486952439 | 0.5 | KIAA0753 OFD1 PIBF1 | Genes related to primary cilium development (based on CRISPR) |
| HP:0002418 | 0.000417247653264 | 0.5 | KIAA0753 OFD1 PIBF1 | Abnormality of midbrain morphology |
| HP:0004422 | 0.000684694628873 | 0.5 | KIAA0753 OFD1 PIBF1 | Biparietal narrowing |
| HP:0009084 | 0.00210158306671 | 0.333333333333 | KIAA0753 OFD1 | Midline notch of upper alveolar ridge |
| HP:0007036 | 0.00210158306671 | 0.333333333333 | KIAA0753 OFD1 | Hypoplasia of olfactory tract |
| HP:0006145 | 0.00270155144475 | 0.333333333333 | KIAA0753 OFD1 | Central Y-shaped metacarpal |
| HP:0002789 | 0.00275483584429 | 0.5 | KIAA0753 OFD1 PIBF1 | Tachypnea |
| HP:0001829 | 0.00293356764265 | 0.5 | KIAA0753 OFD1 PIBF1 | Foot polydactyly |
| HP:0009136 | 0.00331377105913 | 0.5 | KIAA0753 OFD1 PIBF1 | Duplication involving bones of the feet |
| HP:0002444 | 0.00337633448894 | 0.333333333333 | KIAA0753 OFD1 | Hypothalamic hamartoma |
| HP:0000199 | 0.00412589193299 | 0.333333333333 | KIAA0753 OFD1 | Tongue nodules |
| HP:0002553 | 0.00489918791641 | 0.5 | KIAA0753 OFD1 PIBF1 | Highly arched eyebrow |
| HP:0006042 | 0.00495018352279 | 0.333333333333 | KIAA0753 OFD1 | Y-shaped metacarpals |
| HP:0009731 | 0.00584916901642 | 0.333333333333 | KIAA0753 OFD1 | Cerebral hamartoma |
| HP:0012286 | 0.00584916901642 | 0.333333333333 | KIAA0753 OFD1 | Abnormal hypothalamus morphology |
| HP:0000180 | 0.00584916901642 | 0.333333333333 | KIAA0753 OFD1 | Lobulated tongue |
| GO:0071539 | 0.00592798461195 | 0.5 | CEP131 PIBF1 KIAA0753 | protein localization to centrosome |
| GO:1905508 | 0.00661098268806 | 0.5 | CEP131 PIBF1 KIAA0753 | protein localization to microtubule organizing center |
| GO:0005813 | 0.00753328148896 | 0.833333333333 | KIAA0753 CEP131 PIBF1 OFD1 SSX2IP | centrosome |
| HP:0100260 | 0.00787106080828 | 0.333333333333 | KIAA0753 OFD1 | Mesoaxial polydactyly |
| HP:0011802 | 0.0101912456166 | 0.333333333333 | KIAA0753 OFD1 | Hamartoma of tongue |
| HP:0001161 | 0.0113217289996 | 0.5 | KIAA0753 OFD1 PIBF1 | Hand polydactyly |
| HP:0000426 | 0.0134508380869 | 0.5 | KIAA0753 OFD1 PIBF1 | Prominent nasal bridge |
| HP:0001320 | 0.0139573410906 | 0.5 | KIAA0753 OFD1 PIBF1 | Cerebellar vermis hypoplasia |
| HP:0000276 | 0.0142152524621 | 0.5 | KIAA0753 OFD1 PIBF1 | Long face |
| HP:0008689 | 0.0142301190129 | 0.333333333333 | KIAA0753 OFD1 | Bilateral cryptorchidism |
| WP:WP4656 | 0.0145014121643 | 0.333333333333 | PIBF1 OFD1 | Joubert Syndrome |
| HP:0009997 | 0.0169695716892 | 0.5 | KIAA0753 OFD1 PIBF1 | Duplication of phalanx of hand |
| HP:0004275 | 0.0172629242154 | 0.5 | KIAA0753 OFD1 PIBF1 | Duplication of hand bones |
| HP:0009142 | 0.0172629242154 | 0.5 | KIAA0753 OFD1 PIBF1 | Duplication of bones involving the upper extremities |
| HP:0100729 | 0.0200551569888 | 0.5 | KIAA0753 OFD1 PIBF1 | Large face |
| HP:0006817 | 0.0200551569888 | 0.5 | KIAA0753 OFD1 PIBF1 | Aplasia/Hypoplasia of the cerebellar vermis |
| GO:0072698 | 0.0222806450818 | 0.5 | CEP131 PIBF1 KIAA0753 | protein localization to microtubule cytoskeleton |
| HP:0010442 | 0.0261119911272 | 0.5 | KIAA0753 OFD1 PIBF1 | Polydactyly |
| HP:0100648 | 0.0262553193116 | 0.333333333333 | KIAA0753 OFD1 | Neoplasm of the tongue |
| HP:0002104 | 0.0265015994402 | 0.5 | KIAA0753 OFD1 PIBF1 | Apnea |
| HP:0002334 | 0.0289200021372 | 0.5 | KIAA0753 OFD1 PIBF1 | Abnormality of the cerebellar vermis |
| GO:0044380 | 0.0292571070793 | 0.5 | CEP131 PIBF1 KIAA0753 | protein localization to cytoskeleton |
| GO:0005815 | 0.0297798443372 | 0.833333333333 | KIAA0753 CEP131 PIBF1 OFD1 SSX2IP | microtubule organizing center |
| HP:0006477 | 0.032521154219 | 0.333333333333 | KIAA0753 OFD1 | Abnormality of the alveolar ridges |
| REAC:R-HSA-380259 | 0.0484536768126 | 0.333333333333 | CEP131 OFD1 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0484536768126 | 0.333333333333 | CEP131 OFD1 | Loss of proteins required for interphase microtubule organization from the centrosome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KIAA0753 | OFD1 | 0.988 | 0.901 | hein_WMM gupta (KIAA0753,OFD1) youn_WMM hein (OFD1) gupta_WMM |
| CEP131 | OFD1 | 0.987 | 0.901 | hein_WMM gupta (OFD1) youn_WMM hein (CEP131,OFD1) gupta_WMM |
| CEP131 | CCDC138 | 0.982 | 0.897 | hein_WMM bioplex_WMM youn_WMM hein (CEP131) gupta_WMM |
| CEP131 | PIBF1 | 0.978 | 0.894 | hein_WMM bioplex_WMM boldt (PIBF1) youn_WMM hein (CEP131) gupta_WMM boldt_WMM |
| OFD1 | PIBF1 | 0.978 | 0.894 | hein_WMM gupta (OFD1) youn_WMM hein (OFD1) gupta_WMM |
| OFD1 | CCDC138 | 0.975 | 0.887 | hein_WMM gupta (OFD1) youn_WMM hein (OFD1) gupta_WMM |
| CEP131 | SSX2IP | 0.951 | 0.858 | hein_WMM bioplex_WMM gupta (SSX2IP) youn_WMM hein (CEP131) gupta_WMM |
| CEP131 | KIAA0753 | 0.949 | 0.858 | hein_WMM gupta (KIAA0753) youn_WMM hein (CEP131) gupta_WMM |
| SSX2IP | OFD1 | 0.815 | 0.773 | hein_WMM gupta (OFD1,SSX2IP) youn_WMM hein (OFD1) gupta_WMM |
| SSX2IP | PIBF1 | 0.101 | 0.364 | hein_WMM gupta (SSX2IP) youn_WMM gupta_WMM |
| KIAA0753 | SSX2IP | 0.038 | 0.263 | hein_WMM gupta (KIAA0753,SSX2IP) youn_WMM gupta_WMM |
| KIAA0753 | PIBF1 | 0.021 | 0.19 | hein_WMM gupta (KIAA0753) youn_WMM gupta_WMM |
| PIBF1 | CCDC138 | 0.015 | 0.145 | hein_WMM youn_WMM gupta_WMM WMM_only |
| SSX2IP | CCDC138 | 0.009 | 0.09 | hein_WMM gupta (SSX2IP) youn_WMM gupta_WMM |
| KIAA0753 | CCDC138 | 0.007 | 0.001 | hein_WMM gupta (KIAA0753) youn_WMM gupta_WMM |
Images
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Complex HuMAP2_00388 has an average edge precision of 0.594 which is ranked 1967 out of all 6965 complexes.
Related Complexes