hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00389
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CASP1 | Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10] | UniProt NCBI |
| CASP12 | Inactive caspase-12 (CASP-12) | UniProt NCBI |
| PI4KB | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) | UniProt NCBI |
| RDM1 | RAD52 motif-containing protein 1 (RAD52 homolog B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2447 | 0.00117729775616 | 0.5 | CASP1 CASP12 | Amyotrophic lateral sclerosis (ALS) |
| KEGG:05014 | 0.00254347186047 | 0.5 | CASP1 CASP12 | Amyotrophic lateral sclerosis (ALS) |
| GO:0072557 | 0.0162267366884 | 0.5 | CASP1 CASP12 | IPAF inflammasome complex |
| KEGG:04621 | 0.0245056398731 | 0.5 | CASP1 CASP12 | NOD-like receptor signaling pathway |
| GO:0097169 | 0.0270421395626 | 0.5 | CASP1 CASP12 | AIM2 inflammasome complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CASP12 | CASP1 | 0.566 | 0.654 | bioplex (CASP1) bioplex_WMM |
| CASP1 | PI4KB | 0.5 | 0.621 | bioplex (CASP1) bioplex_WMM |
| PI4KB | RDM1 | 0.072 | 0.353 | bioplex (RDM1) bioplex_WMM |
| CASP12 | PI4KB | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00389 has an average edge precision of 0.427 which is ranked 3045 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CASP1 | HuMAP2_00389 HuMAP2_01283 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |
| CASP12 | HuMAP2_00389 HuMAP2_01283 HuMAP2_03028 HuMAP2_05088 |
| PI4KB | HuMAP2_00389 HuMAP2_01283 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |
| RDM1 | HuMAP2_00389 HuMAP2_02324 HuMAP2_03028 HuMAP2_05088 |