hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00392
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BIRC7 | Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] | UniProt NCBI |
| DUSP22 | Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x) | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | UniProt NCBI |
| OSTM1 | Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) | UniProt NCBI |
| LRRN2 | Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5) | UniProt NCBI |
| DIABLO | Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) | UniProt NCBI |
| XPNPEP3 | Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) | UniProt NCBI |
| GNA14 | Guanine nucleotide-binding protein subunit alpha-14 (G alpha-14) (G-protein subunit alpha-14) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04215 | 0.00428986512 | 0.285714285714 | XIAP BIRC7 | Apoptosis - multiple species |
| HP:0003256 | 0.00614659531063 | 0.428571428571 | XIAP GNA14 OSTM1 | Abnormality of the coagulation cascade |
| MIRNA:hsa-miR-593-3p | 0.00762919743866 | 0.428571428571 | XIAP OSTM1 XPNPEP3 | hsa-miR-593-3p |
| MIRNA:hsa-miR-6818-3p | 0.00941984745118 | 0.428571428571 | XIAP OSTM1 XPNPEP3 | hsa-miR-6818-3p |
| MIRNA:hsa-miR-6895-3p | 0.0106166991977 | 0.428571428571 | XIAP OSTM1 XPNPEP3 | hsa-miR-6895-3p |
| MIRNA:hsa-miR-4421 | 0.0110368546879 | 0.428571428571 | XIAP OSTM1 XPNPEP3 | hsa-miR-4421 |
| MIRNA:hsa-miR-5699-3p | 0.0110368546879 | 0.428571428571 | XIAP OSTM1 XPNPEP3 | hsa-miR-5699-3p |
| HP:0005561 | 0.0135169732343 | 0.428571428571 | XIAP GNA14 OSTM1 | Abnormality of bone marrow cell morphology |
| HP:0001928 | 0.0233252077163 | 0.428571428571 | XIAP GNA14 OSTM1 | Abnormality of coagulation |
| WP:WP1772 | 0.0320594299787 | 0.285714285714 | XIAP BIRC7 | Apoptosis Modulation and Signaling |
| HP:0004311 | 0.0344585130221 | 0.285714285714 | XIAP OSTM1 | Abnormal macrophage morphology |
| KEGG:05222 | 0.0407115897186 | 0.285714285714 | XIAP BIRC7 | Small cell lung cancer |
| KEGG:05145 | 0.0424917688807 | 0.285714285714 | XIAP BIRC7 | Toxoplasmosis |
| HP:0011900 | 0.0499089185913 | 0.285714285714 | XIAP GNA14 | Hypofibrinogenemia |
| HP:0011898 | 0.0499089185913 | 0.285714285714 | XIAP GNA14 | Abnormality of circulating fibrinogen |
| CORUM:6292 | 0.0499886427319 | 0.142857142857 | XIAP | HAX-1-XIAP complex |
| CORUM:3177 | 0.0499886427319 | 0.142857142857 | GNA14 | GNA14-p115RhoGEF complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XIAP | DIABLO | 0.528 | 0.633 | bioplex (DIABLO) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| BIRC7 | DIABLO | 0.181 | 0.436 | bioplex (BIRC7) bioplex_WMM |
| DUSP22 | DIABLO | 0.151 | 0.411 | bioplex (DIABLO) bioplex_WMM |
| BIRC7 | OSTM1 | 0.031 | 0.239 | bioplex (BIRC7) bioplex_WMM |
| XIAP | LRRN2 | 0.025 | 0.218 | bioplex (LRRN2) bioplex_WMM |
| DUSP22 | GNA14 | 0.024 | 0.214 | bioplex (DUSP22) bioplex_WMM |
| BIRC7 | XPNPEP3 | 0.022 | 0.208 | bioplex (BIRC7) bioplex_WMM |
| DUSP22 | XIAP | 0.008 | 0.014 | bioplex_WMM WMM_only |
| DIABLO | OSTM1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| XIAP | OSTM1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| DIABLO | XPNPEP3 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| XPNPEP3 | OSTM1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| DUSP22 | XPNPEP3 | 0.007 | 0.003 | bioplex (DUSP22) |
| XIAP | XPNPEP3 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| XIAP | BIRC7 | 0.0 | 0.003 | bioplex (BIRC7) bioplex_WMM |
Images
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Complex HuMAP2_00392 has an average edge precision of 0.16 which is ranked 6625 out of all 6965 complexes.
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