hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00408
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFAF4 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | UniProt NCBI |
| NDUFA13 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic and interferon-induced mortality 19 protein) (GRIM-19) (Gene associated with retinoic and IFN-induced mortality 19 protein) (NADH-ubiquinone oxidoreductase B16.6 subunit) | UniProt NCBI |
| ERCC8 | DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA) | UniProt NCBI |
| NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Complex I subunit B13) (Complex I-13kD-B) (CI-13kD-B) (NADH-ubiquinone oxidoreductase 13 kDa-B subunit) | UniProt NCBI |
| NDUFA3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 (Complex I-B9) (CI-B9) (NADH-ubiquinone oxidoreductase B9 subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 2.63882357435e-08 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-6799198 | 9.86146100692e-08 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | Complex I biogenesis |
| REAC:R-HSA-611105 | 1.10830176838e-06 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | Respiratory electron transport |
| REAC:R-HSA-163200 | 2.59920773791e-06 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:04714 | 8.87396200102e-06 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | Thermogenesis |
| REAC:R-HSA-1428517 | 1.07790500798e-05 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | The citric acid (TCA) cycle and respiratory electron transport |
| CORUM:178 | 1.33027752945e-05 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Respiratory chain complex I (holoenzyme), mitochondrial |
| GO:0032981 | 6.3459788413e-05 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | mitochondrial respiratory chain complex I assembly |
| GO:0010257 | 6.3459788413e-05 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | NADH dehydrogenase complex assembly |
| KEGG:00190 | 0.000228199807064 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Oxidative phosphorylation |
| KEGG:05012 | 0.000278060757653 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Parkinson disease |
| WP:WP4396 | 0.000278228795868 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Nonalcoholic fatty liver disease |
| GO:0033108 | 0.000310236355112 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | mitochondrial respiratory chain complex assembly |
| KEGG:04723 | 0.000319861510109 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Retrograde endocannabinoid signaling |
| KEGG:04932 | 0.000327209764734 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:05010 | 0.000508464109821 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Alzheimer disease |
| KEGG:05016 | 0.000759162382225 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | Huntington disease |
| CORUM:2920 | 0.000803529153956 | 0.4 | NDUFA5 NDUFA13 | Respiratory chain complex I (lambda subunit) mitochondrial |
| HPA:040010_03 | 0.00138757999701 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | seminal vesicle; glandular cells[Uncertain,High] |
| HPA:004020_03 | 0.00141761796239 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | breast; glandular cells[Uncertain,High] |
| HPA:039010_03 | 0.0020194015879 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | salivary gland; glandular cells[Uncertain,High] |
| HPA:053010_03 | 0.00274389756005 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | testis; Leydig cells[Uncertain,High] |
| HPA:016010_03 | 0.00301776600893 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | esophagus; squamous epithelial cells[Uncertain,High] |
| HPA:002010_03 | 0.00465470253249 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | appendix; glandular cells[Uncertain,High] |
| WP:WP623 | 0.00492385173449 | 0.4 | NDUFA5 NDUFA3 | Oxidative phosphorylation |
| HPA:050020_13 | 0.00528686324555 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | spleen; cells in white pulp[Supported,High] |
| HPA:032010_03 | 0.0057419029171 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | pancreas; exocrine glandular cells[Uncertain,High] |
| HPA:008050_12 | 0.00607910367342 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | cerebral cortex; neuropil[Supported,Medium] |
| HPA:008050_02 | 0.00762440114631 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | cerebral cortex; neuropil[Uncertain,Medium] |
| GO:0003954 | 0.00763446836913 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | NADH dehydrogenase activity |
| GO:0008137 | 0.00763446836913 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | NADH dehydrogenase (ubiquinone) activity |
| GO:0050136 | 0.00763446836913 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | NADH dehydrogenase (quinone) activity |
| HPA:001040_03 | 0.00897794495935 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | adrenal gland; glandular cells[Uncertain,High] |
| HPA:007020_13 | 0.00901475212821 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | cerebellum; cells in granular layer[Supported,High] |
| HPA:024020_03 | 0.00901792299187 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | kidney; cells in tubules[Uncertain,High] |
| HP:0011400 | 0.0090867811499 | 0.6 | NDUFAF4 ERCC8 NDUFA13 | Abnormal CNS myelination |
| HPA:021010_13 | 0.00941151154461 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | heart muscle; myocytes[Supported,High] |
| HPA:052010_03 | 0.00980294859364 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | stomach 2; glandular cells[Uncertain,High] |
| HPA:008050_13 | 0.0114904123749 | 0.4 | NDUFA5 NDUFA3 | cerebral cortex; neuropil[Supported,High] |
| HPA:051010_03 | 0.0116204846712 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | stomach 1; glandular cells[Uncertain,High] |
| HPA:006020_13 | 0.0118008675053 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | caudate; neuronal cells[Supported,High] |
| GO:0045271 | 0.0119783897598 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | respiratory chain complex I |
| GO:0005747 | 0.0119783897598 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | mitochondrial respiratory chain complex I |
| GO:0030964 | 0.0119783897598 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | NADH dehydrogenase complex |
| GO:0006120 | 0.0128326937391 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | mitochondrial electron transport, NADH to ubiquinone |
| HPA:011020_03 | 0.0140075399642 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | colon; glandular cells[Uncertain,High] |
| WP:WP111 | 0.0141122881464 | 0.4 | NDUFA5 NDUFA3 | Electron Transport Chain (OXPHOS system in mitochondria) |
| HPA:026020_03 | 0.0141605257552 | 0.6 | NDUFAF4 NDUFA3 NDUFA13 | liver; hepatocytes[Uncertain,High] |
| HPA:022020_13 | 0.0142926539929 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | hippocampus; neuronal cells[Supported,High] |
| HPA:040010_13 | 0.0165184888819 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | seminal vesicle; glandular cells[Supported,High] |
| HPA:050020_03 | 0.0165184888819 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | spleen; cells in white pulp[Uncertain,High] |
| HPA:007010_13 | 0.0168117813986 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | cerebellum; Purkinje cells[Supported,High] |
| HPA:004020_13 | 0.017108483906 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | breast; glandular cells[Supported,High] |
| HPA:033010_13 | 0.0186438016587 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | parathyroid gland; glandular cells[Supported,High] |
| HPA:012010_03 | 0.018724590353 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | duodenum; glandular cells[Uncertain,High] |
| HPA:019010_03 | 0.019211507936 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | gallbladder; glandular cells[Uncertain,High] |
| GO:0016655 | 0.0199719657189 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| HPA:053010_13 | 0.0201008073159 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | testis; Leydig cells[Supported,High] |
| HPA:004010_01 | 0.022333020999 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | breast; adipocytes[Uncertain,Low] |
| HPA:039010_13 | 0.0236024900229 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | salivary gland; glandular cells[Supported,High] |
| HPA:004030_03 | 0.0249166933231 | 0.6 | NDUFA5 NDUFA3 NDUFAF4 | breast; myoepithelial cells[Uncertain,High] |
| HPA:007020_03 | 0.0254943343705 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | cerebellum; cells in granular layer[Uncertain,High] |
| HPA:002010_13 | 0.0293581469203 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | appendix; glandular cells[Supported,High] |
| HPA:016010_13 | 0.0293581469203 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | esophagus; squamous epithelial cells[Supported,High] |
| HPA:008030_13 | 0.0302177023038 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | cerebral cortex; neuronal cells[Supported,High] |
| HPA:024020_13 | 0.0319860664233 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | kidney; cells in tubules[Supported,High] |
| HPA:035010_02 | 0.0370687019401 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | placenta; decidual cells[Uncertain,Medium] |
| HPA:046010_02 | 0.0381079541693 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | smooth muscle; smooth muscle cells[Uncertain,Medium] |
| HPA:006020_03 | 0.0384529972986 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | caudate; neuronal cells[Uncertain,High] |
| HPA:043010_02 | 0.0389310484763 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | skin 1; Langerhans[Uncertain,Medium] |
| HPA:007020_02 | 0.0396469664079 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | cerebellum; cells in granular layer[Uncertain,Medium] |
| HPA:047010_01 | 0.0407390500899 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | soft tissue 1; adipocytes[Uncertain,Low] |
| HPA:001040_13 | 0.0437586981176 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | adrenal gland; glandular cells[Supported,High] |
| HPA:048010_01 | 0.0446716220879 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | soft tissue 2; adipocytes[Uncertain,Low] |
| GO:0098803 | 0.0452171392335 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | respiratory chain complex |
| HPA:032020_02 | 0.0468077801381 | 0.8 | NDUFA5 NDUFA3 NDUFA13 NDUFAF4 | pancreas; islets of Langerhans[Uncertain,Medium] |
| HPA:032010_13 | 0.0468711310654 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | pancreas; exocrine glandular cells[Supported,High] |
| HPA:008050_11 | 0.0471610584035 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | cerebral cortex; neuropil[Supported,Low] |
| GO:0005746 | 0.0472676873043 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | mitochondrial respirasome |
| HPA:022020_03 | 0.0498234389619 | 0.6 | NDUFA5 NDUFA3 NDUFA13 | hippocampus; neuronal cells[Uncertain,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERCC8 | NDUFA13 | 0.103 | 0.366 | bioplex (NDUFA13) bioplex_WMM |
| NDUFA3 | NDUFA13 | 0.091 | 0.354 | bioplex (NDUFA13) bioplex_WMM boldt boldt_WMM |
| NDUFAF4 | NDUFA13 | 0.059 | 0.328 | bioplex (NDUFA13) bioplex_WMM boldt boldt_WMM |
| NDUFA5 | NDUFA13 | 0.027 | 0.23 | hein_WMM bioplex (NDUFA13) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| NDUFA5 | NDUFA3 | 0.008 | 0.057 | bioplex_WMM boldt boldt_WMM |
| NDUFA3 | ERCC8 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| NDUFA5 | ERCC8 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| ERCC8 | NDUFAF4 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| NDUFA3 | NDUFAF4 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| NDUFA5 | NDUFAF4 | 0.006 | 0.011 | bioplex_WMM boldt youn_WMM boldt_WMM |
Images
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Complex HuMAP2_00408 has an average edge precision of 0.137 which is ranked 6794 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFAF4 | HuMAP2_00408 HuMAP2_01573 HuMAP2_03703 HuMAP2_04606 HuMAP2_04892 HuMAP2_05273 |
| NDUFA13 | HuMAP2_00408 HuMAP2_01573 HuMAP2_02247 HuMAP2_04606 HuMAP2_05273 |
| ERCC8 | HuMAP2_00408 HuMAP2_04606 HuMAP2_05273 HuMAP2_06252 |
| NDUFA5 | HuMAP2_00408 HuMAP2_01573 HuMAP2_06566 |
| NDUFA3 | HuMAP2_00408 HuMAP2_01573 HuMAP2_04606 HuMAP2_05273 |