hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00418
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DDR1 | Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) | UniProt NCBI |
| TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | UniProt NCBI |
| IL37 | Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37) | UniProt NCBI |
| FAS | Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95) | UniProt NCBI |
| TNFRSF10A | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) | UniProt NCBI |
| FADD | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) (Protein FADD) | UniProt NCBI |
| DECR1 | 2,4-dienoyl-CoA reductase, mitochondrial (EC 1.3.1.34) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1) | UniProt NCBI |
| RNF149 | E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149) | UniProt NCBI |
| LSS | Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC) | UniProt NCBI |
| CASP8 | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | UniProt NCBI |
| FAM118B | Protein FAM118B | UniProt NCBI |
| UGCG | Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371378 | 3.94303577381e-12 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Regulation by c-FLIP |
| REAC:R-HSA-5218900 | 3.94303577381e-12 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | CASP8 activity is inhibited |
| REAC:R-HSA-69416 | 3.94303577381e-12 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Dimerization of procaspase-8 |
| REAC:R-HSA-140534 | 4.02121974515e-11 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Caspase activation via Death Receptors in the presence of ligand |
| REAC:R-HSA-5675482 | 1.36317345883e-10 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Regulation of necroptotic cell death |
| REAC:R-HSA-5218859 | 2.67182124456e-10 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Regulated Necrosis |
| REAC:R-HSA-5213460 | 2.67182124456e-10 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5357769 | 8.19905076071e-10 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Caspase activation via extrinsic apoptotic signalling pathway |
| REAC:R-HSA-75158 | 2.03917063449e-09 | 0.333333333333 | CASP8 TNFRSF10A FADD TNFRSF10B | TRAIL signaling |
| CORUM:5473 | 2.47891894852e-08 | 0.25 | CASP8 FADD FAS | DISC complex (FAS, FADD, CASP8) |
| CORUM:5860 | 2.47891894852e-08 | 0.25 | CASP8 FADD FAS | DISC complex (FAS, FADD, CASP8) |
| CORUM:5800 | 2.47891894852e-08 | 0.25 | CASP8 FADD FAS | DISC complex (FAS, FADD, CASP8) |
| CORUM:5799 | 9.91118107838e-08 | 0.25 | CASP8 FADD FAS | DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced |
| CORUM:5859 | 9.91118107838e-08 | 0.25 | CASP8 FADD FAS | FAS-FADD-CASP8-CASP10 complex |
| WP:WP1772 | 2.17156134625e-07 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Apoptosis Modulation and Signaling |
| GO:1902042 | 6.31917241051e-07 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO:0036462 | 8.43853741187e-07 | 0.333333333333 | CASP8 TNFRSF10A FADD TNFRSF10B | TRAIL-activated apoptotic signaling pathway |
| REAC:R-HSA-75157 | 9.64346710801e-07 | 0.25 | CASP8 FADD FAS | FasL/ CD95L signaling |
| KEGG:04210 | 1.31959523039e-06 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Apoptosis |
| GO:0071260 | 2.41637335758e-06 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | cellular response to mechanical stimulus |
| KEGG:05164 | 3.0816478757e-06 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Influenza A |
| KEGG:04217 | 3.52204638828e-06 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Necroptosis |
| GO:1902041 | 3.68603808788e-06 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| REAC:R-HSA-73887 | 7.2992311452e-06 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Death Receptor Signalling |
| KEGG:05130 | 7.53821467369e-06 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Pathogenic Escherichia coli infection |
| REAC:R-HSA-6803211 | 1.15459538873e-05 | 0.25 | TNFRSF10A FAS TNFRSF10B | TP53 Regulates Transcription of Death Receptors and Ligands |
| WP:WP254 | 1.71722889401e-05 | 0.333333333333 | CASP8 TNFRSF10B FADD FAS | Apoptosis |
| WP:WP384 | 2.17943847471e-05 | 0.25 | CASP8 FADD FAS | Apoptosis Modulation by HSP70 |
| WP:WP2507 | 2.58690961365e-05 | 0.25 | CASP8 FADD FAS | Nanomaterial induced apoptosis |
| GO:0008625 | 2.66173721416e-05 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | extrinsic apoptotic signaling pathway via death domain receptors |
| REAC:R-HSA-109581 | 3.18015361064e-05 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Apoptosis |
| REAC:R-HSA-5357801 | 3.47215092867e-05 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | Programmed Cell Death |
| CORUM:5808 | 3.69160609814e-05 | 0.166666666667 | CASP8 FADD | DISC complex (CD95, FADD, CASP8) |
| GO:2001237 | 5.23432147235e-05 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0006919 | 6.59802516794e-05 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO:0009612 | 7.65466862041e-05 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | response to mechanical stimulus |
| CORUM:6414 | 0.000110698604565 | 0.166666666667 | CASP8 FADD | RIPK1-FADD-caspase-8 complex |
| CORUM:5991 | 0.000110698604565 | 0.166666666667 | CASP8 FADD | LRRK2-FADD-CASP8 complex |
| CORUM:5798 | 0.000110698604565 | 0.166666666667 | CASP8 FADD | Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced |
| CORUM:5861 | 0.000110698604565 | 0.166666666667 | FADD FAS | FAS-FADD-CASP10 complex |
| KEGG:04061 | 0.000127762236376 | 0.25 | TNFRSF10A TNFRSF10B IL37 | Viral protein interaction with cytokine and cytokine receptor |
| GO:0031265 | 0.000199619769136 | 0.25 | CASP8 FADD FAS | CD95 death-inducing signaling complex |
| CORUM:2054 | 0.00022129809732 | 0.166666666667 | CASP8 FADD | CASP8-FADD-MALT1-BCL10 complex |
| KEGG:04060 | 0.000269881821086 | 0.333333333333 | IL37 TNFRSF10A FAS TNFRSF10B | Cytokine-cytokine receptor interaction |
| GO:2001236 | 0.00029170314364 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | regulation of extrinsic apoptotic signaling pathway |
| WP:WP314 | 0.000303296658252 | 0.25 | CASP8 FADD FAS | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| GO:0043280 | 0.000424804937495 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| KEGG:04115 | 0.000736115308299 | 0.25 | CASP8 FAS TNFRSF10B | p53 signaling pathway |
| GO:2001056 | 0.00087285688034 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | positive regulation of cysteine-type endopeptidase activity |
| REAC:R-HSA-5633008 | 0.00093776778838 | 0.25 | TNFRSF10A FAS TNFRSF10B | TP53 Regulates Transcription of Cell Death Genes |
| KEGG:01524 | 0.00104989263753 | 0.25 | CASP8 FADD FAS | Platinum drug resistance |
| GO:0031264 | 0.00111635111712 | 0.25 | CASP8 FADD FAS | death-inducing signaling complex |
| WP:WP707 | 0.00125134777341 | 0.25 | CASP8 FAS TNFRSF10B | DNA Damage Response |
| WP:WP1530 | 0.00142794130111 | 0.25 | CASP8 FAS TNFRSF10B | miRNA Regulation of DNA Damage Response |
| GO:0010950 | 0.00170079035084 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | positive regulation of endopeptidase activity |
| KEGG:05142 | 0.00191778644203 | 0.25 | CASP8 FADD FAS | Chagas disease (American trypanosomiasis) |
| WP:WP2059 | 0.00213350484968 | 0.25 | CASP8 FADD FAS | Alzheimers Disease |
| GO:0097191 | 0.00213734750928 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | extrinsic apoptotic signaling pathway |
| REAC:R-HSA-9013957 | 0.00215225370556 | 0.166666666667 | CASP8 FADD | TLR3-mediated TICAM1-dependent programmed cell death |
| GO:0010952 | 0.00221805105113 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | positive regulation of peptidase activity |
| KEGG:04668 | 0.0022626923312 | 0.25 | CASP8 FADD FAS | TNF signaling pathway |
| WP:WP2513 | 0.00263124287192 | 0.166666666667 | CASP8 FADD | Nanoparticle triggered regulated necrosis |
| KEGG:04650 | 0.00272748489508 | 0.25 | TNFRSF10A FAS TNFRSF10B | Natural killer cell mediated cytotoxicity |
| GO:2001234 | 0.00285335690316 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | negative regulation of apoptotic signaling pathway |
| GO:0043281 | 0.00338981266327 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| REAC:R-HSA-2562578 | 0.00401394410135 | 0.166666666667 | CASP8 FADD | TRIF-mediated programmed cell death |
| KEGG:05162 | 0.00585853039674 | 0.25 | CASP8 FADD FAS | Measles |
| GO:2000116 | 0.00639067988615 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | regulation of cysteine-type endopeptidase activity |
| KEGG:05160 | 0.0070113553479 | 0.25 | CASP8 FADD FAS | Hepatitis C |
| GO:0071496 | 0.00852832096842 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | cellular response to external stimulus |
| WP:WP3982 | 0.00916820913052 | 0.166666666667 | CASP8 TNFRSF10B | miRNA regulation of p53 pathway in prostate cancer |
| REAC:R-HSA-933543 | 0.00944450943881 | 0.166666666667 | CASP8 FADD | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| REAC:R-HSA-5357786 | 0.00944450943881 | 0.166666666667 | CASP8 FADD | TNFR1-induced proapoptotic signaling |
| KEGG:05010 | 0.0101233513321 | 0.25 | CASP8 FADD FAS | Alzheimer disease |
| KEGG:05161 | 0.0103184585809 | 0.25 | CASP8 FADD FAS | Hepatitis B |
| KEGG:04215 | 0.0116199008721 | 0.166666666667 | CASP8 FADD | Apoptosis - multiple species |
| KEGG:05167 | 0.0124053831682 | 0.25 | CASP8 FADD FAS | Kaposi sarcoma-associated herpesvirus infection |
| WP:WP4666 | 0.0125463419785 | 0.25 | CASP8 FADD FAS | Hepatitis B infection |
| GO:0104004 | 0.0148607633535 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | cellular response to environmental stimulus |
| GO:0071214 | 0.0148607633535 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | cellular response to abiotic stimulus |
| KEGG:05169 | 0.016816576084 | 0.25 | CASP8 FADD FAS | Epstein-Barr virus infection |
| KEGG:05170 | 0.0214959632141 | 0.25 | CASP8 FADD FAS | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0224572432878 | 0.25 | CASP8 FADD FAS | Human cytomegalovirus infection |
| GO:0045569 | 0.029754345151 | 0.166666666667 | TNFRSF10B TNFRSF10A | TRAIL binding |
| WP:WP2036 | 0.0307091204693 | 0.166666666667 | CASP8 FADD | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| GO:0052548 | 0.0376326817762 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | regulation of endopeptidase activity |
| GO:2001233 | 0.0451459861019 | 0.416666666667 | CASP8 TNFRSF10B TNFRSF10A FADD FAS | regulation of apoptotic signaling pathway |
| CORUM:6158 | 0.0499809905632 | 0.0833333333333 | TNFRSF10B | TRIAL-DR5 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FADD | IL37 | 0.528 | 0.633 | bioplex (FADD) bioplex_WMM |
| CASP8 | TNFRSF10B | 0.268 | 0.482 | bioplex (TNFRSF10B) bioplex_WMM |
| FADD | TNFRSF10B | 0.244 | 0.468 | bioplex (TNFRSF10B) bioplex_WMM |
| CASP8 | TNFRSF10A | 0.126 | 0.4 | bioplex (TNFRSF10A) bioplex_WMM |
| FAS | FADD | 0.075 | 0.357 | bioplex (FAS) bioplex_WMM |
| FAS | FAM118B | 0.07 | 0.348 | bioplex (FAM118B,FAS) bioplex_WMM |
| UGCG | TNFRSF10B | 0.059 | 0.328 | bioplex (TNFRSF10B) bioplex_WMM |
| FADD | TNFRSF10A | 0.053 | 0.298 | bioplex (TNFRSF10A) bioplex_WMM |
| FAS | CASP8 | 0.052 | 0.301 | bioplex (FAS) bioplex_WMM |
| FAM118B | DECR1 | 0.036 | 0.265 | bioplex (FAM118B) bioplex_WMM |
| RNF149 | TNFRSF10B | 0.035 | 0.26 | bioplex (TNFRSF10B) bioplex_WMM |
| DDR1 | TNFRSF10B | 0.035 | 0.266 | bioplex (TNFRSF10B) bioplex_WMM |
| LSS | TNFRSF10A | 0.026 | 0.216 | bioplex (TNFRSF10A) bioplex_WMM |
| TNFRSF10B | TNFRSF10A | 0.019 | 0.186 | bioplex (TNFRSF10A) bioplex_WMM |
| UGCG | TNFRSF10A | 0.016 | 0.165 | bioplex (TNFRSF10A) bioplex_WMM |
| CASP8 | FADD | 0.013 | 0.15 | bioplex_WMM WMM_only |
| RNF149 | UGCG | 0.012 | 0.149 | bioplex_WMM WMM_only |
| DDR1 | CASP8 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| DDR1 | FADD | 0.009 | 0.091 | bioplex_WMM WMM_only |
| FADD | UGCG | 0.008 | 0.088 | bioplex_WMM WMM_only |
| CASP8 | UGCG | 0.008 | 0.088 | bioplex_WMM WMM_only |
| DDR1 | UGCG | 0.008 | 0.081 | bioplex_WMM WMM_only |
| RNF149 | DDR1 | 0.008 | 0.032 | bioplex_WMM WMM_only |
| LSS | FADD | 0.007 | 0.005 | bioplex_WMM WMM_only |
| LSS | CASP8 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| RNF149 | FADD | 0.007 | 0.007 | bioplex_WMM WMM_only |
| RNF149 | CASP8 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| FADD | FAM118B | 0.007 | 0.008 | bioplex_WMM WMM_only |
| CASP8 | FAM118B | 0.007 | 0.008 | bioplex_WMM WMM_only |
| RNF149 | TNFRSF10A | 0.007 | 0.009 | bioplex (TNFRSF10A) bioplex_WMM |
| LSS | UGCG | 0.007 | 0.004 | bioplex_WMM WMM_only |
| LSS | TNFRSF10B | 0.007 | 0.002 | bioplex_WMM WMM_only |
| RNF149 | LSS | 0.007 | 0.005 | bioplex_WMM WMM_only |
| FAS | UGCG | 0.006 | 0.003 | bioplex_WMM WMM_only |
| FAS | RNF149 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| FAS | DECR1 | 0.006 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00418 has an average edge precision of 0.162 which is ranked 6615 out of all 6965 complexes.
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