hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00427

Confidence: Medium

Genename	Protein Name	Links
NCBP1	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)	UniProt NCBI
NCBP2	Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (Cell proliferation-inducing gene 55 protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1)	UniProt NCBI
PHAX	Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein)	UniProt NCBI
LENG1	Leukocyte receptor cluster member 1	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1174	6.75231048499e-10	0.75	NCBP2 NCBP1 PHAX	PHAX-CBC complex (cap binding complex)
CORUM:1176	6.75163031135e-09	0.75	NCBP2 NCBP1 PHAX	CRM1-RAN-PHAX-CBC complex (cap binding complex)
CORUM:1172	5.02777038712e-06	0.5	NCBP2 NCBP1	CBC complex (cap binding complex)
CORUM:775	5.02777038712e-06	0.5	NCBP2 NCBP1	CBC complex (cap binding complex)
REAC:R-HSA-191859	2.64063995051e-05	0.75	NCBP2 NCBP1 PHAX	snRNP Assembly
REAC:R-HSA-194441	2.64063995051e-05	0.75	NCBP2 NCBP1 PHAX	Metabolism of non-coding RNA
CORUM:6129	7.53895486054e-05	0.5	NCBP2 NCBP1	CBP80/20- dependent translation complex
REAC:R-HSA-6807505	8.72293047842e-05	0.75	NCBP2 NCBP1 PHAX	RNA polymerase II transcribes snRNA genes
KEGG:03013	0.000156303289806	0.75	NCBP2 NCBP1 PHAX	RNA transport
REAC:R-HSA-111367	0.000452175281072	0.5	NCBP2 NCBP1	SLBP independent Processing of Histone Pre-mRNAs
REAC:R-HSA-77588	0.000552609179875	0.5	NCBP2 NCBP1	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
REAC:R-HSA-8851708	0.00171688133139	0.5	NCBP2 NCBP1	Signaling by FGFR2 IIIa TM
REAC:R-HSA-77595	0.00171688133139	0.5	NCBP2 NCBP1	Processing of Intronless Pre-mRNAs
REAC:R-HSA-167242	0.00253927088831	0.5	NCBP2 NCBP1	Abortive elongation of HIV-1 transcript in the absence of Tat
GO:0005846	0.00270494046827	0.5	NCBP2 NCBP1	nuclear cap binding complex
GO:0006408	0.00270494046827	0.5	NCBP2 PHAX	snRNA export from nucleus
REAC:R-HSA-1839126	0.00301045354831	0.5	NCBP2 NCBP1	FGFR2 mutant receptor activation
REAC:R-HSA-6803529	0.00326103241616	0.5	NCBP2 NCBP1	FGFR2 alternative splicing
REAC:R-HSA-75067	0.00379215175563	0.5	NCBP2 NCBP1	Processing of Capped Intronless Pre-mRNA
REAC:R-HSA-72086	0.00407268683926	0.5	NCBP2 NCBP1	mRNA Capping
REAC:R-HSA-159227	0.00436320194063	0.5	NCBP2 NCBP1	Transport of the SLBP independent Mature mRNA
REAC:R-HSA-159230	0.00466369436644	0.5	NCBP2 NCBP1	Transport of the SLBP Dependant Mature mRNA
REAC:R-HSA-113418	0.00529460041948	0.5	NCBP2 NCBP1	Formation of the Early Elongation Complex
REAC:R-HSA-167158	0.00529460041948	0.5	NCBP2 NCBP1	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-5655253	0.00562500866147	0.5	NCBP2 NCBP1	Signaling by FGFR2 in disease
REAC:R-HSA-159231	0.00667602194349	0.5	NCBP2 NCBP1	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-159234	0.0070462802506	0.5	NCBP2 NCBP1	Transport of Mature mRNAs Derived from Intronless Transcripts
KEGG:03015	0.00761107721317	0.5	NCBP2 NCBP1	mRNA surveillance pathway
GO:0051030	0.00811409485621	0.5	NCBP2 PHAX	snRNA transport
REAC:R-HSA-167200	0.00947680746611	0.5	NCBP2 NCBP1	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167169	0.00947680746611	0.5	NCBP2 NCBP1	HIV Transcription Elongation
REAC:R-HSA-167246	0.00947680746611	0.5	NCBP2 NCBP1	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167152	0.0103665290697	0.5	NCBP2 NCBP1	Formation of HIV elongation complex in the absence of HIV Tat
WP:WP411	0.0128777248997	0.5	NCBP2 NCBP1	mRNA Processing
REAC:R-HSA-72165	0.013274030298	0.5	NCBP2 NCBP1	mRNA Splicing - Minor Pathway
REAC:R-HSA-1226099	0.0137933430055	0.5	NCBP2 NCBP1	Signaling by FGFR in disease
REAC:R-HSA-72187	0.0143225711665	0.5	NCBP2 NCBP1	mRNA 3'-end processing
REAC:R-HSA-5654738	0.0165385846138	0.5	NCBP2 NCBP1	Signaling by FGFR2
KEGG:03040	0.016608760826	0.5	NCBP2 NCBP1	Spliceosome
REAC:R-HSA-75955	0.017117349746	0.5	NCBP2 NCBP1	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	0.017117349746	0.5	NCBP2 NCBP1	Formation of RNA Pol II elongation complex
REAC:R-HSA-73856	0.0195313767937	0.5	NCBP2 NCBP1	RNA Polymerase II Transcription Termination
GO:0042795	0.0198185309013	0.75	NCBP2 NCBP1 PHAX	snRNA transcription by RNA polymerase II
GO:0009301	0.0206918321066	0.75	NCBP2 NCBP1 PHAX	snRNA transcription
REAC:R-HSA-190236	0.0221036214141	0.5	NCBP2 NCBP1	Signaling by FGFR
REAC:R-HSA-159236	0.0227713839361	0.5	NCBP2 NCBP1	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-167172	0.0248339118539	0.5	NCBP2 NCBP1	Transcription of the HIV genome
REAC:R-HSA-72202	0.0292253078855	0.5	NCBP2 NCBP1	Transport of Mature Transcript to Cytoplasm
REAC:R-HSA-674695	0.0331557329305	0.5	NCBP2 NCBP1	RNA Polymerase II Pre-transcription Events
REAC:R-HSA-975956	0.0435915557177	0.5	NCBP2 NCBP1	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
CORUM:351	0.0483178514014	0.5	NCBP2 NCBP1	Spliceosome
CORUM:1190	0.0499140284799	0.25	NCBP1	NCBP-NIP1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
NCBP2	PHAX	0.093	0.355	hein_WMM youn (NCBP2) bioplex_WMM youn_WMM hein (NCBP2)
NCBP2	NCBP1	0.048	0.293	hein_WMM youn (NCBP2) bioplex_WMM Guru youn_WMM hein (NCBP1,NCBP2) fraction
NCBP1	PHAX	0.026	0.22	hein_WMM bioplex_WMM youn_WMM hein (NCBP1,PHAX) gupta_WMM
NCBP2	LENG1	0.023	0.208	hein_WMM hein (NCBP2)
LENG1	PHAX	0.007	0.003	hein_WMM youn_WMM WMM_only
NCBP1	LENG1	0.007	0.004	hein_WMM youn_WMM WMM_only

Images

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Complex HuMAP2_00427 has an average edge precision of 0.18 which is ranked 6425 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NCBP1	HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06277
NCBP2	HuMAP2_00359 HuMAP2_00427 HuMAP2_01066 HuMAP2_06019 HuMAP2_06262 HuMAP2_06277 HuMAP2_06561
PHAX	HuMAP2_00427 HuMAP2_06019 HuMAP2_06277
LENG1	HuMAP2_00427 HuMAP2_06019 HuMAP2_06277

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00427