hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00430
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RFC1 | Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) | UniProt NCBI |
| RFC2 | Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) | UniProt NCBI |
| RFC3 | Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) | UniProt NCBI |
| RFC5 | Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:279 | 2.26724547881e-13 | 1.0 | RFC5 RFC1 RFC2 RFC3 | RFC complex |
| CORUM:277 | 2.26724547881e-13 | 1.0 | RFC5 RFC1 RFC2 RFC3 | RFC complex |
| CORUM:2799 | 2.26724547881e-13 | 1.0 | RFC5 RFC1 RFC2 RFC3 | RFC complex |
| CORUM:2203 | 6.80173643643e-13 | 1.0 | RFC5 RFC1 RFC2 RFC3 | BRD4-RFC complex |
| CORUM:1003 | 5.7134586066e-12 | 1.0 | RFC5 RFC1 RFC2 RFC3 | RC complex (Replication competent complex) |
| REAC:R-HSA-69109 | 9.07805089715e-11 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Leading Strand Synthesis |
| REAC:R-HSA-69091 | 9.07805089715e-11 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Polymerase switching |
| REAC:R-HSA-174411 | 9.07805089715e-11 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Polymerase switching on the C-strand of the telomere |
| GO:0005663 | 1.2197780676e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA replication factor C complex |
| KEGG:03430 | 1.60016811683e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Mismatch repair |
| REAC:R-HSA-110312 | 1.65055470857e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Translesion synthesis by REV1 |
| REAC:R-HSA-5656121 | 2.15841769583e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Translesion synthesis by POLI |
| REAC:R-HSA-5655862 | 2.15841769583e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Translesion synthesis by POLK |
| REAC:R-HSA-110320 | 3.51513739035e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Translesion Synthesis by POLH |
| REAC:R-HSA-69186 | 4.39392173793e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 5.42778567627e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-174417 | 9.63670018313e-10 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03030 | 1.06445966033e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA replication |
| REAC:R-HSA-110373 | 1.14722621228e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 1.14722621228e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| WP:WP466 | 1.69602185225e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA Replication |
| KEGG:03420 | 2.45312729563e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Nucleotide excision repair |
| REAC:R-HSA-110314 | 2.48535449387e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 2.48535449387e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Extension of Telomeres |
| CORUM:2200 | 2.70078815927e-09 | 0.75 | RFC5 RFC2 RFC3 | RFC2-5 subcomplex |
| REAC:R-HSA-5656169 | 2.85355515963e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 3.26120589672e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA strand elongation |
| REAC:R-HSA-73933 | 4.74851893082e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 6.69426900073e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| CORUM:2810 | 6.75163031135e-09 | 0.75 | RFC5 RFC2 RFC3 | RAD17-RFC complex |
| CORUM:2201 | 6.75163031135e-09 | 0.75 | RFC5 RFC2 RFC3 | PCNA-RFC2-5 complex |
| CORUM:2202 | 6.75163031135e-09 | 0.75 | RFC5 RFC2 RFC3 | CHTF18-RFC2-5 complex |
| CORUM:270 | 6.75163031135e-09 | 0.75 | RFC5 RFC2 RFC3 | RAD17-RFC complex |
| CORUM:2199 | 6.75163031135e-09 | 0.75 | RFC5 RFC2 RFC3 | CHTF18-RFC2-5 complex |
| CORUM:266 | 6.75163031135e-09 | 0.75 | RFC5 RFC2 RFC3 | RAD17-RFC complex |
| REAC:R-HSA-5696400 | 9.18415798556e-09 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Dual Incision in GG-NER |
| CORUM:2797 | 1.3502580449e-08 | 0.75 | RFC5 RFC2 RFC3 | PCNA-CHL12-RFC2-5 complex |
| REAC:R-HSA-73893 | 1.61758895931e-08 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA Damage Bypass |
| CORUM:2804 | 2.3628325482e-08 | 0.75 | RFC5 RFC2 RFC3 | CTF18-cohesion-RFC complex |
| CORUM:274 | 3.78034162849e-08 | 0.75 | RFC5 RFC2 RFC3 | 9-1-1-RAD17-RFC complex |
| CORUM:3070 | 3.78034162849e-08 | 0.75 | RFC5 RFC2 RFC3 | CTF18-cohesion-RFC-POLH complex |
| CORUM:268 | 3.78034162849e-08 | 0.75 | RFC5 RFC2 RFC3 | 9-1-1-RAD17-RFC complex |
| REAC:R-HSA-6782210 | 5.76221345338e-08 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 6.14006351589e-08 | 1.0 | RFC5 RFC1 RFC2 RFC3 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6782135 | 6.14006351589e-08 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Dual incision in TC-NER |
| GO:0070987 | 1.1819649475e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | error-free translesion synthesis |
| GO:0042276 | 1.1819649475e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | error-prone translesion synthesis |
| REAC:R-HSA-6781827 | 1.29362225284e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 1.50884279717e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Telomere Maintenance |
| REAC:R-HSA-5696399 | 1.74986096744e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-73884 | 2.01866015002e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Base Excision Repair |
| GO:0006297 | 2.16022695772e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | nucleotide-excision repair, DNA gap filling |
| GO:0032201 | 4.28142101727e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | telomere maintenance via semi-conservative replication |
| REAC:R-HSA-73886 | 4.8601535637e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 5.23569103583e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 6.95938708355e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Synthesis of DNA |
| REAC:R-HSA-69306 | 9.07725736124e-07 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA Replication |
| REAC:R-HSA-5693567 | 1.03013477297e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 1.23644957705e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Homology Directed Repair |
| GO:0042769 | 1.43702054144e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA damage response, detection of DNA damage |
| GO:0006296 | 1.61120484949e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| GO:0033683 | 2.00655931676e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | nucleotide-excision repair, DNA incision |
| GO:0019985 | 2.22951035196e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | translesion synthesis |
| REAC:R-HSA-69242 | 2.3250149843e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | S Phase |
| REAC:R-HSA-5693532 | 2.63463002689e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA Double-Strand Break Repair |
| GO:0000731 | 3.98098967922e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA synthesis involved in DNA repair |
| GO:0006301 | 5.61829777936e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | postreplication repair |
| GO:0033260 | 6.60448834702e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | nuclear DNA replication |
| GO:0044786 | 8.96024572897e-06 | 1.0 | RFC5 RFC1 RFC2 RFC3 | cell cycle DNA replication |
| REAC:R-HSA-5685938 | 9.62627312117e-06 | 0.75 | RFC5 RFC2 RFC3 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 1.04751216664e-05 | 0.75 | RFC5 RFC2 RFC3 | Activation of ATR in response to replication stress |
| REAC:R-HSA-5693616 | 1.13724154433e-05 | 0.75 | RFC5 RFC2 RFC3 | Presynaptic phase of homologous DNA pairing and strand exchange |
| GO:1900264 | 1.27120391093e-05 | 0.75 | RFC5 RFC2 RFC3 | positive regulation of DNA-directed DNA polymerase activity |
| GO:1900262 | 1.27120391093e-05 | 0.75 | RFC5 RFC2 RFC3 | regulation of DNA-directed DNA polymerase activity |
| REAC:R-HSA-5693579 | 1.436837348e-05 | 0.75 | RFC5 RFC2 RFC3 | Homologous DNA Pairing and Strand Exchange |
| CORUM:278 | 1.50819606993e-05 | 0.5 | RFC2 RFC5 | RFC core complex |
| GO:0005657 | 1.55003541896e-05 | 1.0 | RFC5 RFC1 RFC2 RFC3 | replication fork |
| GO:0003689 | 2.03382379613e-05 | 0.75 | RFC5 RFC2 RFC3 | DNA clamp loader activity |
| GO:0033170 | 2.03382379613e-05 | 0.75 | RFC5 RFC2 RFC3 | protein-DNA loading ATPase activity |
| GO:0031390 | 2.03382379613e-05 | 0.75 | RFC5 RFC2 RFC3 | Ctf18 RFC-like complex |
| GO:0006283 | 2.65528608423e-05 | 1.0 | RFC5 RFC1 RFC2 RFC3 | transcription-coupled nucleotide-excision repair |
| REAC:R-HSA-73894 | 3.93749583955e-05 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA Repair |
| CORUM:435 | 7.53895486054e-05 | 0.5 | RFC2 RFC1 | BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) |
| GO:0006289 | 0.000116616394242 | 1.0 | RFC5 RFC1 RFC2 RFC3 | nucleotide-excision repair |
| CORUM:434 | 0.000140701954484 | 0.5 | RFC2 RFC1 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) |
| REAC:R-HSA-6804756 | 0.000163333735977 | 0.75 | RFC5 RFC2 RFC3 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 0.000180191665247 | 0.75 | RFC5 RFC2 RFC3 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.000198169454442 | 0.75 | RFC5 RFC2 RFC3 | Processing of DNA double-strand break ends |
| GO:0017116 | 0.000246852342475 | 0.75 | RFC5 RFC2 RFC3 | single-stranded DNA helicase activity |
| GO:0006261 | 0.000252118978237 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA-dependent DNA replication |
| GO:0090305 | 0.000260251848503 | 1.0 | RFC5 RFC1 RFC2 RFC3 | nucleic acid phosphodiester bond hydrolysis |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Cell Cycle, Mitotic |
| CORUM:433 | 0.000331535811226 | 0.5 | RFC2 RFC1 | BASC complex (BRCA1-associated genome surveillance complex) |
| CORUM:1004 | 0.000391779955301 | 0.5 | RFC2 RFC1 | RC complex during S-phase of cell cycle |
| CORUM:1005 | 0.000391779955301 | 0.5 | RFC2 RFC1 | RC complex during G2/M-phase of cell cycle |
| GO:0071897 | 0.000407446981099 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA biosynthetic process |
| GO:0000723 | 0.000494260781771 | 1.0 | RFC5 RFC1 RFC2 RFC3 | telomere maintenance |
| GO:0051606 | 0.000535430121219 | 1.0 | RFC5 RFC1 RFC2 RFC3 | detection of stimulus |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | RFC5 RFC1 RFC2 RFC3 | Cell Cycle |
| GO:0032200 | 0.000691429733885 | 1.0 | RFC5 RFC1 RFC2 RFC3 | telomere organization |
| REAC:R-HSA-5633007 | 0.000847823442334 | 0.75 | RFC5 RFC2 RFC3 | Regulation of TP53 Activity |
| REAC:R-HSA-69481 | 0.001021027578 | 0.75 | RFC5 RFC2 RFC3 | G2/M Checkpoints |
| GO:0006260 | 0.00184822285327 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA replication |
| GO:0042623 | 0.00195799214531 | 1.0 | RFC5 RFC1 RFC2 RFC3 | ATPase activity, coupled |
| GO:0090329 | 0.00331394418715 | 0.75 | RFC5 RFC2 RFC3 | regulation of DNA-dependent DNA replication |
| REAC:R-HSA-69620 | 0.00518999523011 | 0.75 | RFC5 RFC2 RFC3 | Cell Cycle Checkpoints |
| WP:WP2446 | 0.00623747495525 | 0.5 | RFC3 RFC5 | Retinoblastoma Gene in Cancer |
| GO:0060249 | 0.00629241325149 | 1.0 | RFC5 RFC1 RFC2 RFC3 | anatomical structure homeostasis |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | RFC5 RFC2 RFC3 | Transcriptional Regulation by TP53 |
| GO:0016887 | 0.0096936769593 | 1.0 | RFC5 RFC1 RFC2 RFC3 | ATPase activity |
| GO:2000573 | 0.0106004966657 | 0.75 | RFC5 RFC2 RFC3 | positive regulation of DNA biosynthetic process |
| GO:0003678 | 0.0106004966657 | 0.75 | RFC5 RFC2 RFC3 | DNA helicase activity |
| GO:0006275 | 0.0275320606423 | 0.75 | RFC5 RFC2 RFC3 | regulation of DNA replication |
| GO:2000278 | 0.0396936057372 | 0.75 | RFC5 RFC2 RFC3 | regulation of DNA biosynthetic process |
| GO:0004386 | 0.0424904593616 | 0.75 | RFC5 RFC2 RFC3 | helicase activity |
| GO:0006281 | 0.042993565242 | 1.0 | RFC5 RFC1 RFC2 RFC3 | DNA repair |
| GO:0008094 | 0.0454154921687 | 0.75 | RFC5 RFC2 RFC3 | DNA-dependent ATPase activity |
| CORUM:1131 | 0.0499140284799 | 0.25 | RFC2 | RFC2-RIalpha complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RFC3 | RFC5 | 1.0 | 0.949 | hein_WMM bioplex (RFC5) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| RFC2 | RFC3 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RFC2 | RFC5 | 0.999 | 0.948 | hein_WMM bioplex (RFC5) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| RFC1 | RFC5 | 0.988 | 0.901 | hein_WMM bioplex (RFC5) bioplex_WMM Guru youn_WMM fraction |
| RFC3 | RFC1 | 0.936 | 0.85 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
| RFC2 | RFC1 | 0.098 | 0.357 | hein_WMM bioplex_WMM Guru youn_WMM fraction |
Images
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Complex HuMAP2_00430 has an average edge precision of 0.826 which is ranked 851 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RFC1 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02847 HuMAP2_03572 |
| RFC2 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 |
| RFC3 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 |
| RFC5 | HuMAP2_00430 HuMAP2_00874 HuMAP2_02712 HuMAP2_02847 |