hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00435
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CISD1 | CDGSH iron-sulfur domain-containing protein 1 (MitoNEET) | UniProt NCBI |
| CISD2 | CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1) | UniProt NCBI |
| VDAC1 | Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) | UniProt NCBI |
| VDAC3 | Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | UniProt NCBI |
| DPM1 | Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8949215 | 0.00340529843133 | 0.4 | VDAC1 VDAC3 | Mitochondrial calcium ion transport |
| KEGG:04979 | 0.00385577589725 | 0.4 | VDAC1 VDAC3 | Cholesterol metabolism |
| KEGG:05012 | 0.0332521613209 | 0.4 | VDAC1 VDAC3 | Parkinson disease |
| KEGG:04022 | 0.0415917953149 | 0.4 | VDAC1 VDAC3 | cGMP-PKG signaling pathway |
| KEGG:04218 | 0.0439700127241 | 0.4 | VDAC1 VDAC3 | Cellular senescence |
| KEGG:04217 | 0.0482876775804 | 0.4 | VDAC1 VDAC3 | Necroptosis |
| CORUM:5244 | 0.0499494897235 | 0.2 | DPM1 | Dolichol-phosphate mannose (DPM) synthase |
| CORUM:7275 | 0.0499494897235 | 0.2 | CISD2 | BCL2-CISD2 complex |
| CORUM:7418 | 0.0499494897235 | 0.2 | VDAC1 | HK1-VDAC1 complex |
| CORUM:7529 | 0.0499494897235 | 0.2 | VDAC1 | APP-Abeta42-VDAC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CISD1 | VDAC1 | 0.331 | 0.522 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM |
| CISD1 | VDAC3 | 0.244 | 0.468 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM |
| VDAC3 | CISD2 | 0.043 | 0.27 | bioplex_WMM Guru gupta_WMM fraction |
| CISD1 | DPM1 | 0.025 | 0.211 | bioplex_WMM boldt fraction boldt_WMM |
| VDAC1 | CISD2 | 0.025 | 0.21 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| VDAC1 | VDAC3 | 0.019 | 0.184 | hein_WMM bioplex (VDAC1,VDAC3) bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM |
| CISD1 | CISD2 | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
| DPM1 | CISD2 | 0.006 | 0.006 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| VDAC1 | DPM1 | 0.006 | 0.009 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| VDAC3 | DPM1 | 0.003 | 0.018 | bioplex (VDAC3) bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_00435 has an average edge precision of 0.19 which is ranked 6308 out of all 6965 complexes.
Related Complexes