hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00441
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PELP1 | Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3) | UniProt NCBI |
| TEX10 | Testis-expressed protein 10 | UniProt NCBI |
| SENP3 | Sentrin-specific protease 3 (EC 3.4.22.-) (SUMO-1-specific protease 3) (Sentrin/SUMO-specific protease SENP3) | UniProt NCBI |
| ISCA1 | Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA) | UniProt NCBI |
| NUDT6 | Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG) | UniProt NCBI |
| LAS1L | Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog) | UniProt NCBI |
| WDR18 | WD repeat-containing protein 18 | UniProt NCBI |
| NOL9 | Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6855 | 8.55866679422e-20 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | LAS1L-PELP1-TEX10-WDR18-NOL9-SENP3 complex |
| CORUM:6854 | 4.24766632997e-16 | 0.625 | TEX10 LAS1L SENP3 WDR18 PELP1 | 5FMC (Friends of Methylated Chtop) complex |
| CORUM:6857 | 4.70911134935e-09 | 0.375 | TEX10 WDR18 PELP1 | PELP1-TEX10-WDR18 complex |
| REAC:R-HSA-6791226 | 1.44265796861e-08 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 1.99852365652e-08 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 2.72213237006e-08 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | rRNA processing |
| CORUM:5386 | 2.76130385377e-08 | 0.5 | LAS1L SENP3 PELP1 TEX10 | MLL1-WDR5 complex |
| GO:0006364 | 3.09258730955e-06 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | rRNA processing |
| GO:0016072 | 4.20649812162e-06 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | rRNA metabolic process |
| GO:0042254 | 1.97441445367e-05 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | ribosome biogenesis |
| GO:0044665 | 2.98220816207e-05 | 0.5 | LAS1L SENP3 PELP1 TEX10 | MLL1/2 complex |
| GO:0071339 | 2.98220816207e-05 | 0.5 | LAS1L SENP3 PELP1 TEX10 | MLL1 complex |
| REAC:R-HSA-8953854 | 3.16815271587e-05 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | Metabolism of RNA |
| GO:0034470 | 0.000115337312222 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | ncRNA processing |
| GO:0022613 | 0.000303124403181 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | ribonucleoprotein complex biogenesis |
| GO:0034660 | 0.000490983461322 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | ncRNA metabolic process |
| GO:0035097 | 0.00265701097616 | 0.5 | LAS1L SENP3 PELP1 TEX10 | histone methyltransferase complex |
| GO:0034708 | 0.00861930713405 | 0.5 | LAS1L SENP3 PELP1 TEX10 | methyltransferase complex |
| GO:0097344 | 0.0126230555186 | 0.25 | WDR18 TEX10 | Rix1 complex |
| HPA:047020_02 | 0.0235902719481 | 0.5 | NUDT6 SENP3 PELP1 LAS1L | soft tissue 1; chondrocytes[Uncertain,Medium] |
| GO:0006396 | 0.0243548281027 | 0.75 | WDR18 LAS1L NOL9 TEX10 SENP3 PELP1 | RNA processing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR18 | PELP1 | 1.0 | 0.949 | hein_WMM bioplex (WDR18) bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| WDR18 | TEX10 | 1.0 | 0.949 | hein_WMM bioplex (WDR18) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR18 | SENP3 | 1.0 | 0.949 | bioplex (WDR18) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| PELP1 | TEX10 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| PELP1 | SENP3 | 1.0 | 0.949 | bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| TEX10 | SENP3 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| LAS1L | NOL9 | 1.0 | 0.949 | bioplex (NOL9) bioplex_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| TEX10 | NOL9 | 0.999 | 0.949 | bioplex (NOL9) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| PELP1 | NOL9 | 0.988 | 0.902 | bioplex (NOL9) bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| PELP1 | LAS1L | 0.976 | 0.892 | hein_WMM bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| WDR18 | NOL9 | 0.976 | 0.888 | bioplex (NOL9,WDR18) bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| TEX10 | LAS1L | 0.879 | 0.813 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR18 | LAS1L | 0.816 | 0.773 | bioplex (WDR18) bioplex_WMM youn_WMM Malo fraction treiber_WMM |
| SENP3 | NOL9 | 0.302 | 0.497 | bioplex (NOL9) bioplex_WMM youn_WMM gupta_WMM |
| WDR18 | ISCA1 | 0.092 | 0.355 | bioplex (WDR18) bioplex_WMM |
| NUDT6 | ISCA1 | 0.034 | 0.264 | bioplex (NUDT6) bioplex_WMM |
| LAS1L | SENP3 | 0.008 | 0.079 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| NUDT6 | NOL9 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| NUDT6 | LAS1L | 0.007 | 0.001 | bioplex_WMM WMM_only |
| LAS1L | ISCA1 | 0.006 | 0.006 | bioplex_WMM WMM_only |
| TEX10 | ISCA1 | 0.006 | 0.007 | bioplex_WMM WMM_only |
| SENP3 | ISCA1 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| NOL9 | ISCA1 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| PELP1 | ISCA1 | 0.006 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00441 has an average edge precision of 0.545 which is ranked 2231 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PELP1 | HuMAP2_00441 HuMAP2_01430 HuMAP2_03649 HuMAP2_04092 HuMAP2_06152 HuMAP2_06210 |
| TEX10 | HuMAP2_00441 HuMAP2_03649 HuMAP2_06152 HuMAP2_06210 |
| SENP3 | HuMAP2_00441 HuMAP2_03649 HuMAP2_06152 |
| ISCA1 | HuMAP2_00441 HuMAP2_04853 HuMAP2_06152 |
| NUDT6 | HuMAP2_00441 HuMAP2_04853 |
| LAS1L | HuMAP2_00441 HuMAP2_03649 HuMAP2_06152 |
| WDR18 | HuMAP2_00441 HuMAP2_03649 HuMAP2_06152 HuMAP2_06210 |
| NOL9 | HuMAP2_00441 HuMAP2_03649 HuMAP2_06152 |