hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00448
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBE2D3 | Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3) | UniProt NCBI |
| UBE2D4 | Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) | UniProt NCBI |
| RNF25 | E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING-type E3 ubiquitin transferase RNF25) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05131 | 0.000900335185999 | 0.666666666667 | UBE2D4 UBE2D3 | Shigellosis |
| REAC:R-HSA-983168 | 0.00184648552156 | 1.0 | UBE2D3 UBE2D4 RNF25 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-983169 | 0.00315795701338 | 1.0 | UBE2D3 UBE2D4 RNF25 | Class I MHC mediated antigen processing & presentation |
| KEGG:04120 | 0.00373360278335 | 0.666666666667 | UBE2D4 UBE2D3 | Ubiquitin mediated proteolysis |
| KEGG:04141 | 0.00544616782939 | 0.666666666667 | UBE2D4 UBE2D3 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-1280218 | 0.0202947578047 | 1.0 | UBE2D3 UBE2D4 RNF25 | Adaptive Immune System |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBE2D4 | RNF25 | 1.0 | 0.949 | bioplex (RNF25) bioplex_WMM |
| RNF25 | UBE2D3 | 0.058 | 0.328 | bioplex (RNF25) bioplex_WMM |
| UBE2D4 | UBE2D3 | 0.008 | 0.009 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00448 has an average edge precision of 0.429 which is ranked 3037 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UBE2D3 | HuMAP2_00448 HuMAP2_01204 HuMAP2_01572 HuMAP2_03533 |
| UBE2D4 | HuMAP2_00448 HuMAP2_00522 HuMAP2_01204 HuMAP2_01572 HuMAP2_03533 HuMAP2_06009 |
| RNF25 | HuMAP2_00448 HuMAP2_00522 HuMAP2_01204 HuMAP2_01572 HuMAP2_03533 HuMAP2_03702 HuMAP2_06009 |