hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00450
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKCZ | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | UniProt NCBI |
| PRKCI | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | UniProt NCBI |
| PARD6B | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:955 | 1.00675659188e-05 | 0.666666666667 | PRKCI PARD6B | LLGL2-PAR-6B-PRKCI complex |
| CORUM:959 | 1.00675659188e-05 | 0.666666666667 | PRKCI PARD6B | LLGL1-PAR-6B-PRKCI complex |
| CORUM:956 | 1.00675659188e-05 | 0.666666666667 | PRKCI PARD6B | PAR-3-PAR-6B-PRKCI complex |
| KEGG:04390 | 1.40492126975e-05 | 1.0 | PRKCZ PARD6B PRKCI | Hippo signaling pathway |
| KEGG:04530 | 1.49652172755e-05 | 1.0 | PRKCZ PARD6B PRKCI | Tight junction |
| KEGG:04015 | 2.55027583186e-05 | 1.0 | PRKCZ PARD6B PRKCI | Rap1 signaling pathway |
| KEGG:04144 | 6.09806140287e-05 | 1.0 | PRKCZ PARD6B PRKCI | Endocytosis |
| KEGG:05165 | 0.000150762444884 | 1.0 | PRKCZ PARD6B PRKCI | Human papillomavirus infection |
| WP:WP2012 | 0.000311404659219 | 0.666666666667 | PRKCZ PRKCI | miRs in Muscle Cell Differentiation |
| REAC:R-HSA-420029 | 0.000702607572674 | 0.666666666667 | PRKCI PARD6B | Tight junction interactions |
| KEGG:04611 | 0.00272070891872 | 0.666666666667 | PRKCZ PRKCI | Platelet activation |
| WP:WP2261 | 0.00317409068183 | 0.666666666667 | PRKCZ PRKCI | Signaling Pathways in Glioblastoma |
| KEGG:04910 | 0.00345163215546 | 0.666666666667 | PRKCZ PRKCI | Insulin signaling pathway |
| WP:WP35 | 0.00357470816736 | 0.666666666667 | PRKCZ PRKCI | G Protein Signaling Pathways |
| WP:WP4540 | 0.00357470816736 | 0.666666666667 | PRKCZ PRKCI | Pathways Regulating Hippo Signaling |
| WP:WP399 | 0.00444703604854 | 0.666666666667 | PRKCZ PRKCI | Wnt Signaling Pathway and Pluripotency |
| KEGG:04360 | 0.00601503157228 | 0.666666666667 | PRKCZ PARD6B | Axon guidance |
| REAC:R-HSA-421270 | 0.00632193682699 | 0.666666666667 | PRKCI PARD6B | Cell-cell junction organization |
| WP:WP481 | 0.0112234268693 | 0.666666666667 | PRKCZ PRKCI | Insulin Signaling |
| WP:WP437 | 0.0121147085229 | 0.666666666667 | PRKCZ PRKCI | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-446728 | 0.0165866686159 | 0.666666666667 | PRKCI PARD6B | Cell junction organization |
| WP:WP3888 | 0.0226746026379 | 0.666666666667 | PRKCZ PRKCI | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-1500931 | 0.0350118981581 | 0.666666666667 | PRKCI PARD6B | Cell-Cell communication |
| CORUM:6790 | 0.0499776345577 | 0.333333333333 | PRKCZ | NHERF1-PRKCZ complex |
| CORUM:5558 | 0.0499776345577 | 0.333333333333 | PARD6B | PAR6-CDC42 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKCZ | PARD6B | 1.0 | 0.949 | hein_WMM bioplex (PARD6B,PRKCZ) bioplex_WMM hein (PARD6B) |
| PRKCI | PARD6B | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B,PRKCI) |
| PRKCZ | PRKCI | 0.068 | 0.35 | hein_WMM bioplex (PRKCZ) bioplex_WMM |
Images
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Complex HuMAP2_00450 has an average edge precision of 0.749 which is ranked 1156 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKCZ | HuMAP2_00362 HuMAP2_00450 HuMAP2_01528 HuMAP2_02503 |
| PRKCI | HuMAP2_00450 HuMAP2_01276 HuMAP2_01528 HuMAP2_02503 |
| PARD6B | HuMAP2_00450 HuMAP2_01276 HuMAP2_01528 HuMAP2_02149 HuMAP2_02503 HuMAP2_05511 |