hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00451
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUMF1 | Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1) | UniProt NCBI |
| IDS | Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003541 | 0.000350640431072 | 1.0 | SUMF1 IDS | Urinary glycosaminoglycan excretion |
| HP:0008155 | 0.000350640431072 | 1.0 | SUMF1 IDS | Mucopolysacchariduria |
| HP:0000943 | 0.000634492208607 | 1.0 | SUMF1 IDS | Dysostosis multiplex |
| KEGG:04142 | 0.00100713074717 | 1.0 | SUMF1 IDS | Lysosome |
| REAC:R-HSA-2206296 | 0.0249595281251 | 0.5 | IDS | MPS II - Hunter syndrome |
| KEGG:00531 | 0.0369186440558 | 0.5 | IDS | Glycosaminoglycan degradation |
| HP:0000280 | 0.0462878763342 | 1.0 | SUMF1 IDS | Coarse facial features |
| HP:0007307 | 0.0497341708567 | 0.5 | SUMF1 | Rapid neurologic deterioration |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IDS | SUMF1 | 0.049 | 0.294 | bioplex (IDS) bioplex_WMM |
Images
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Complex HuMAP2_00451 has an average edge precision of 0.294 which is ranked 4687 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUMF1 | HuMAP2_00451 HuMAP2_02252 HuMAP2_03210 |
| IDS | HuMAP2_00114 HuMAP2_00451 HuMAP2_00786 |