hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00461
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CEP85 | Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) | UniProt NCBI |
| SOX1 | Transcription factor SOX-1 | UniProt NCBI |
| SOX6 | Transcription factor SOX-6 | UniProt NCBI |
| SOX11 | Transcription factor SOX-11 | UniProt NCBI |
| SOX13 | Transcription factor SOX-13 (Islet cell antigen 12) (SRY (Sex determining region Y)-box 13) (Type 1 diabetes autoantigen ICA12) | UniProt NCBI |
| SOX5 | Transcription factor SOX-5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4304 | 0.000585450803921 | 0.333333333333 | SOX5 SOX6 | Oligodendrocyte Specification and differentiation(including remyelination), leading to Myelin Components for CNS |
| WP:WP474 | 0.0070633221054 | 0.333333333333 | SOX5 SOX6 | Endochondral Ossification |
| REAC:R-HSA-3769402 | 0.0163206320028 | 0.333333333333 | SOX13 SOX6 | Deactivation of the beta-catenin transactivating complex |
| GO:2000741 | 0.020283420769 | 0.333333333333 | SOX5 SOX6 | positive regulation of mesenchymal stem cell differentiation |
| MIRNA:hsa-miR-136-3p | 0.0388499553328 | 0.333333333333 | SOX5 SOX11 | hsa-miR-136-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SOX13 | SOX5 | 1.0 | 0.949 | bioplex (SOX5) bioplex_WMM |
| SOX6 | SOX5 | 1.0 | 0.949 | bioplex (SOX5) bioplex_WMM |
| CEP85 | SOX13 | 0.94 | 0.853 | bioplex (CEP85) bioplex_WMM |
| SOX11 | SOX5 | 0.901 | 0.826 | bioplex (SOX5) bioplex_WMM |
| CEP85 | SOX5 | 0.762 | 0.749 | bioplex (CEP85) bioplex_WMM |
| SOX1 | SOX5 | 0.702 | 0.723 | bioplex (SOX5) bioplex_WMM |
| SOX1 | SOX6 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOX1 | SOX11 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOX6 | SOX11 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| SOX1 | SOX13 | 0.008 | 0.093 | bioplex_WMM WMM_only |
| SOX11 | SOX13 | 0.008 | 0.093 | bioplex_WMM WMM_only |
| SOX6 | SOX13 | 0.008 | 0.093 | bioplex_WMM WMM_only |
| CEP85 | SOX6 | 0.007 | 0.001 | youn_WMM WMM_only |
Images
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Complex HuMAP2_00461 has an average edge precision of 0.432 which is ranked 3009 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CEP85 | HuMAP2_00461 HuMAP2_00563 HuMAP2_00643 HuMAP2_05597 HuMAP2_06966 |
| SOX1 | HuMAP2_00461 HuMAP2_05597 |
| SOX6 | HuMAP2_00461 HuMAP2_05597 |
| SOX11 | HuMAP2_00461 HuMAP2_05597 |
| SOX13 | HuMAP2_00461 HuMAP2_00643 HuMAP2_05597 HuMAP2_06966 |
| SOX5 | HuMAP2_00461 HuMAP2_05597 HuMAP2_06966 |