hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00474
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HAUS7 | HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) (X-linked protein STS1769) | UniProt NCBI |
| HAUS1 | HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) (Enhancer of invasion-cluster) (HEI-C) | UniProt NCBI |
| HAUS2 | HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27) | UniProt NCBI |
| HAUS4 | HAUS augmin-like complex subunit 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070652 | 1.70768929464e-09 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | HAUS complex |
| CORUM:6435 | 2.3628325482e-08 | 0.75 | HAUS7 HAUS2 HAUS1 | HAUS augmin-like complex |
| REAC:R-HSA-380284 | 6.95119325839e-08 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-380259 | 6.95119325839e-08 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-8854518 | 8.31530417317e-08 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 1.36261543966e-07 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 1.36261543966e-07 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Centrosome maturation |
| REAC:R-HSA-2565942 | 1.74986096744e-07 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-380320 | 2.31729719e-07 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-5620912 | 2.88715120313e-07 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Anchoring of the basal body to the plasma membrane |
| REAC:R-HSA-69275 | 4.77048083087e-06 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | G2/M Transition |
| REAC:R-HSA-5617833 | 4.87252320159e-06 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Cilium Assembly |
| REAC:R-HSA-68877 | 4.87252320159e-06 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Mitotic Prometaphase |
| REAC:R-HSA-453274 | 4.976193908e-06 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Mitotic G2-G2/M phases |
| REAC:R-HSA-1852241 | 2.24070737955e-05 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Organelle biogenesis and maintenance |
| GO:0051225 | 6.2335294411e-05 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | spindle assembly |
| GO:0097711 | 7.43942887385e-05 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | ciliary basal body-plasma membrane docking |
| REAC:R-HSA-68886 | 7.5124113335e-05 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | M Phase |
| GO:0007098 | 0.000130738130864 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | centrosome cycle |
| GO:0031023 | 0.000180861495173 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | microtubule organizing center organization |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Cell Cycle, Mitotic |
| GO:0005875 | 0.000313257328826 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | microtubule associated complex |
| GO:0007051 | 0.000419088323416 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | spindle organization |
| GO:0140056 | 0.000430977353868 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | organelle localization by membrane tethering |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | Cell Cycle |
| GO:0022406 | 0.000549708257785 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | membrane docking |
| GO:0010389 | 0.000942422491033 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | regulation of G2/M transition of mitotic cell cycle |
| GO:1902749 | 0.00133859616125 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | regulation of cell cycle G2/M phase transition |
| GO:0000086 | 0.00249113752463 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | G2/M transition of mitotic cell cycle |
| GO:0044839 | 0.00340048705072 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | cell cycle G2/M phase transition |
| GO:0060271 | 0.0104598779665 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | cilium assembly |
| GO:0044782 | 0.0128783441389 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | cilium organization |
| GO:1901990 | 0.0146522218849 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | regulation of mitotic cell cycle phase transition |
| GO:1901987 | 0.0193609640933 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | regulation of cell cycle phase transition |
| GO:0120031 | 0.0400391581053 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | plasma membrane bounded cell projection assembly |
| GO:0005813 | 0.0426155998333 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | centrosome |
| GO:0030031 | 0.0433740392707 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | cell projection assembly |
| GO:0000226 | 0.0445306239544 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | microtubule cytoskeleton organization |
| GO:0044772 | 0.0485535587519 | 1.0 | HAUS7 HAUS4 HAUS2 HAUS1 | mitotic cell cycle phase transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HAUS7 | HAUS1 | 1.0 | 0.949 | hein_WMM bioplex (HAUS7) bioplex_WMM youn_WMM hein (HAUS1) gupta_WMM |
| HAUS7 | HAUS2 | 1.0 | 0.949 | hein_WMM bioplex (HAUS7) bioplex_WMM youn_WMM hein (HAUS2) gupta_WMM |
| HAUS7 | HAUS4 | 1.0 | 0.949 | hein_WMM bioplex (HAUS7) bioplex_WMM youn_WMM hein (HAUS4) gupta_WMM |
| HAUS1 | HAUS4 | 0.997 | 0.934 | hein_WMM bioplex_WMM boldt youn_WMM hein (HAUS1,HAUS4) gupta_WMM boldt_WMM |
| HAUS4 | HAUS2 | 0.963 | 0.871 | hein_WMM bioplex_WMM youn_WMM hein (HAUS2,HAUS4) gupta_WMM |
| HAUS1 | HAUS2 | 0.905 | 0.828 | hein_WMM bioplex_WMM youn_WMM hein (HAUS1,HAUS2) gupta_WMM |
Images
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Complex HuMAP2_00474 has an average edge precision of 0.913 which is ranked 499 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HAUS7 | HuMAP2_00474 HuMAP2_03612 HuMAP2_04538 HuMAP2_05337 HuMAP2_06334 |
| HAUS1 | HuMAP2_00474 HuMAP2_04538 HuMAP2_05337 HuMAP2_06334 |
| HAUS2 | HuMAP2_00474 HuMAP2_04538 HuMAP2_05337 HuMAP2_06334 |
| HAUS4 | HuMAP2_00474 HuMAP2_04538 HuMAP2_05337 HuMAP2_06334 |