hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00478
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TNRC6A | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | UniProt NCBI |
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | UniProt NCBI |
| TNRC6B | Trinucleotide repeat-containing gene 6B protein | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 3.17414367033e-12 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 6.34828734067e-12 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-8943723 | 1.14269172132e-11 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Regulation of PTEN mRNA translation |
| REAC:R-HSA-8934593 | 2.15841769583e-10 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9022692 | 2.15397389469e-09 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Regulation of MECP2 expression and activity |
| REAC:R-HSA-2559585 | 3.26120589672e-09 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Oncogene Induced Senescence |
| REAC:R-HSA-4086398 | 2.65562462933e-08 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Ca2+ pathway |
| REAC:R-HSA-8986944 | 2.65562462933e-08 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-5628897 | 1.43433204175e-07 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-5687128 | 2.01866015002e-07 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912408 | 2.42383958954e-07 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-8936459 | 2.53401411634e-07 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| REAC:R-HSA-1912422 | 4.68014787616e-07 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-2559580 | 7.96564050645e-07 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Oxidative Stress Induced Senescence |
| GO:0007223 | 9.98266370523e-07 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Wnt signaling pathway, calcium modulating pathway |
| REAC:R-HSA-211000 | 1.09578558651e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Gene Silencing by RNA |
| REAC:R-HSA-6807070 | 1.20008341302e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | PTEN Regulation |
| REAC:R-HSA-3858494 | 1.2736360305e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Beta-catenin independent WNT signaling |
| REAC:R-HSA-9018519 | 1.43083096128e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Estrogen-dependent gene expression |
| REAC:R-HSA-2559583 | 4.57121262574e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Cellular Senescence |
| REAC:R-HSA-8939211 | 6.35361545823e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | ESR-mediated signaling |
| REAC:R-HSA-8878171 | 8.45593016469e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 8.61252146403e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Signaling by NOTCH |
| REAC:R-HSA-1257604 | 9.42834939261e-06 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | PIP3 activates AKT signaling |
| REAC:R-HSA-5683057 | 1.14261241307e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | MAPK family signaling cascades |
| REAC:R-HSA-9006931 | 1.30669973384e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Signaling by Nuclear Receptors |
| REAC:R-HSA-9006925 | 1.76692529985e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Intracellular signaling by second messengers |
| GO:0045652 | 2.37035812542e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | regulation of megakaryocyte differentiation |
| GO:0030219 | 2.80701671762e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | megakaryocyte differentiation |
| REAC:R-HSA-195721 | 3.42260325769e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Signaling by WNT |
| REAC:R-HSA-3700989 | 5.4469226338e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Transcriptional Regulation by TP53 |
| MIRNA:hsa-miR-148b-3p | 8.96160947521e-05 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-148b-3p |
| REAC:R-HSA-2262752 | 0.00010216546718 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Cellular responses to stress |
| GO:0016442 | 0.000103844122491 | 0.75 | TNRC6A AGO1 AGO3 | RISC complex |
| GO:0031332 | 0.000103844122491 | 0.75 | TNRC6A AGO1 AGO3 | RNAi effector complex |
| GO:0035278 | 0.000103844122491 | 0.75 | TNRC6A AGO1 AGO3 | miRNA mediated inhibition of translation |
| GO:0045974 | 0.000103844122491 | 0.75 | TNRC6A AGO1 AGO3 | regulation of translation, ncRNA-mediated |
| GO:0040033 | 0.000103844122491 | 0.75 | TNRC6A AGO1 AGO3 | negative regulation of translation, ncRNA-mediated |
| REAC:R-HSA-8953897 | 0.00021167720149 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Cellular responses to external stimuli |
| GO:0035567 | 0.000285834009959 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | non-canonical Wnt signaling pathway |
| REAC:R-HSA-426486 | 0.000361772624521 | 0.5 | AGO3 AGO1 | Small interfering RNA (siRNA) biogenesis |
| GO:0035195 | 0.000363289575714 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | gene silencing by miRNA |
| GO:0035194 | 0.000468165581659 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | posttranscriptional gene silencing by RNA |
| GO:0016441 | 0.000481080494257 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | posttranscriptional gene silencing |
| MIRNA:hsa-miR-130b-3p | 0.000497701447562 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-130b-3p |
| GO:0045637 | 0.000535430121219 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | regulation of myeloid cell differentiation |
| MIRNA:hsa-miR-19a-3p | 0.000554239129258 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-19a-3p |
| GO:0031047 | 0.000625429030777 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | gene silencing by RNA |
| MIRNA:hsa-miR-152-3p | 0.00131726147577 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-152-3p |
| MIRNA:hsa-miR-19b-3p | 0.00137896196176 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-19b-3p |
| MIRNA:hsa-miR-652-3p | 0.00145691901299 | 0.75 | TNRC6A AGO1 AGO3 | hsa-miR-652-3p |
| GO:0016458 | 0.00272272763799 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | gene silencing |
| REAC:R-HSA-203927 | 0.00276986547413 | 0.5 | AGO3 AGO1 | MicroRNA (miRNA) biogenesis |
| GO:0030099 | 0.00286921344524 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | myeloid cell differentiation |
| MIRNA:hsa-miR-519d-3p | 0.00319713261193 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-519d-3p |
| MIRNA:hsa-miR-148a-3p | 0.00322772199929 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-148a-3p |
| MIRNA:hsa-miR-20b-5p | 0.00338902843923 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-20b-5p |
| REAC:R-HSA-212436 | 0.00429443977897 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Generic Transcription Pathway |
| MIRNA:hsa-miR-20a-5p | 0.00640277914574 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-20a-5p |
| MIRNA:hsa-miR-106b-5p | 0.00661607610723 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-106b-5p |
| REAC:R-HSA-73857 | 0.00664358115488 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | RNA Polymerase II Transcription |
| GO:0040029 | 0.00733907004762 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | regulation of gene expression, epigenetic |
| GO:1903706 | 0.00785572034373 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | regulation of hemopoiesis |
| MIRNA:hsa-miR-107 | 0.00893658160342 | 0.75 | AGO3 AGO1 TNRC6B | hsa-miR-107 |
| MIRNA:hsa-miR-17-5p | 0.0093305744984 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-17-5p |
| REAC:R-HSA-74160 | 0.0102868657133 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Gene expression (Transcription) |
| MIRNA:hsa-miR-93-5p | 0.0109256735263 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | hsa-miR-93-5p |
| GO:0006402 | 0.0128783441389 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | mRNA catabolic process |
| MIRNA:hsa-miR-3666 | 0.0143985168714 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-3666 |
| MIRNA:hsa-miR-4295 | 0.0145310924579 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-4295 |
| MIRNA:hsa-miR-301b-3p | 0.0159016106407 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-301b-3p |
| GO:0016055 | 0.0175518684514 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | Wnt signaling pathway |
| GO:0006401 | 0.0181401540934 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | RNA catabolic process |
| GO:0198738 | 0.0183394964461 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | cell-cell signaling by wnt |
| MIRNA:hsa-miR-130a-3p | 0.0185794478332 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-130a-3p |
| MIRNA:hsa-miR-301a-3p | 0.0187363860651 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-301a-3p |
| MIRNA:hsa-miR-454-3p | 0.0187363860651 | 0.75 | TNRC6A TNRC6B AGO3 | hsa-miR-454-3p |
| GO:1905114 | 0.0243708967076 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | cell surface receptor signaling pathway involved in cell-cell signaling |
| MIRNA:hsa-miR-299-5p | 0.0302525005955 | 0.5 | TNRC6A TNRC6B | hsa-miR-299-5p |
| MIRNA:hsa-miR-26a-5p | 0.0311440984613 | 0.75 | TNRC6A AGO1 TNRC6B | hsa-miR-26a-5p |
| MIRNA:hsa-miR-103a-3p | 0.0311440984613 | 0.75 | AGO3 AGO1 TNRC6B | hsa-miR-103a-3p |
| GO:0034655 | 0.0445306239544 | 1.0 | TNRC6A AGO3 AGO1 TNRC6B | nucleobase-containing compound catabolic process |
| MIRNA:hsa-miR-4528 | 0.048384308251 | 0.5 | TNRC6A AGO3 | hsa-miR-4528 |
| MIRNA:hsa-miR-382-3p | 0.0497427802251 | 0.5 | TNRC6A AGO3 | hsa-miR-382-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TNRC6A | AGO3 | 0.665 | 0.7 | hein_WMM youn (TNRC6A) bioplex_WMM youn_WMM hein (AGO3) |
| TNRC6B | AGO3 | 0.23 | 0.467 | hein_WMM youn (TNRC6B) bioplex_WMM youn_WMM hein (AGO3) |
| AGO1 | TNRC6A | 0.119 | 0.393 | youn (TNRC6A) bioplex_WMM youn_WMM |
| AGO1 | TNRC6B | 0.043 | 0.269 | youn (TNRC6B) bioplex_WMM youn_WMM |
| AGO1 | AGO3 | 0.013 | 0.149 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| TNRC6A | TNRC6B | 0.01 | 0.1 | hein_WMM youn (TNRC6A,TNRC6B) bioplex_WMM youn_WMM gupta_WMM |
Images
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Complex HuMAP2_00478 has an average edge precision of 0.346 which is ranked 4042 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TNRC6A | HuMAP2_00153 HuMAP2_00478 HuMAP2_01955 HuMAP2_06245 |
| AGO1 | HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_00976 HuMAP2_04674 |
| TNRC6B | HuMAP2_00153 HuMAP2_00478 HuMAP2_01955 |
| AGO3 | HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_01955 HuMAP2_04784 HuMAP2_06154 HuMAP2_06245 |