hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00480
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NADK2 | NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial) | UniProt NCBI |
| STRADB | STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2) | UniProt NCBI |
| STRADA | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | UniProt NCBI |
| SDR39U1 | Epimerase family protein SDR39U1 (EC 1.1.1.-) (Short-chain dehydrogenase/reductase family 39U member 1) | UniProt NCBI |
| CAB39 | Calcium-binding protein 39 (MO25alpha) (Protein Mo25) | UniProt NCBI |
| FDXR | NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase) | UniProt NCBI |
| TP53I3 | Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein) | UniProt NCBI |
| MVD | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | UniProt NCBI |
| CAB39L | Calcium-binding protein 39-like (Antigen MLAA-34) (MO25beta) (Mo25-like protein) | UniProt NCBI |
| BPNT1 | 3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380972 | 1.61883151402e-09 | 0.454545454545 | STRADB STK11 CAB39 CAB39L STRADA | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 9.44863380121e-09 | 0.454545454545 | STRADB STK11 CAB39 CAB39L STRADA | mTOR signalling |
| CORUM:6053 | 2.02774899104e-08 | 0.272727272727 | STK11 STRADA CAB39 | LKB1-STRAD-MO25 complex |
| KEGG:04152 | 4.41224982084e-07 | 0.454545454545 | STRADB STK11 CAB39 CAB39L STRADA | AMPK signaling pathway |
| KEGG:04150 | 1.56500177776e-06 | 0.454545454545 | STRADB STK11 CAB39 CAB39L STRADA | mTOR signaling pathway |
| WP:WP1403 | 6.76702157808e-06 | 0.363636363636 | STK11 STRADB STRADA CAB39 | AMP-activated Protein Kinase (AMPK) Signaling |
| WP:WP3595 | 0.00050247669008 | 0.181818181818 | STK11 STRADB | mir-124 predicted interactions with cell cycle and differentiation |
| WP:WP3932 | 0.00173111929325 | 0.363636363636 | STK11 CAB39 CAB39L STRADA | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0007050 | 0.00677695590772 | 0.454545454545 | STRADB STK11 CAB39 CAB39L STRADA | cell cycle arrest |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAB39L | CAB39 | 0.992 | 0.912 | bioplex (CAB39L) bioplex_WMM |
| STRADA | STK11 | 0.976 | 0.889 | bioplex (STK11) bioplex_WMM |
| CAB39 | STRADB | 0.907 | 0.83 | bioplex (STRADB) bioplex_WMM |
| CAB39L | STRADA | 0.893 | 0.819 | bioplex (CAB39L) bioplex_WMM |
| STK11 | STRADB | 0.602 | 0.671 | bioplex (STK11,STRADB) bioplex_WMM |
| STK11 | CAB39 | 0.09 | 0.354 | bioplex (STK11) bioplex_WMM |
| CAB39 | BPNT1 | 0.082 | 0.351 | fraction |
| CAB39 | MVD | 0.037 | 0.265 | fraction |
| SDR39U1 | BPNT1 | 0.033 | 0.249 | bioplex (BPNT1) bioplex_WMM |
| NADK2 | MVD | 0.03 | 0.235 | fraction |
| CAB39L | STK11 | 0.029 | 0.231 | bioplex (CAB39L) bioplex_WMM |
| CAB39L | MVD | 0.023 | 0.208 | fraction |
| BPNT1 | TP53I3 | 0.021 | 0.194 | fraction |
| FDXR | BPNT1 | 0.02 | 0.187 | bioplex (BPNT1) bioplex_WMM gupta_WMM |
| CAB39L | BPNT1 | 0.02 | 0.188 | fraction |
| STRADA | CAB39 | 0.012 | 0.15 | bioplex_WMM WMM_only |
| STRADA | STRADB | 0.008 | 0.038 | bioplex_WMM WMM_only |
| SDR39U1 | FDXR | 0.007 | 0.005 | bioplex_WMM WMM_only |
| FDXR | NADK2 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| NADK2 | BPNT1 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| FDXR | MVD | 0.003 | 0.011 | fraction |
Images
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Complex HuMAP2_00480 has an average edge precision of 0.324 which is ranked 4293 out of all 6965 complexes.
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