hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00481
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GTF2E2 | Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2) | UniProt NCBI |
| GTF2E1 | General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha) | UniProt NCBI |
| GTF2F2 | General transcription factor IIF subunit 2 (EC 3.6.4.12) (ATP-dependent helicase GTF2F2) (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30) | UniProt NCBI |
| GTF2F1 | General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:103 | 4.81835009157e-10 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA polymerase II holoenzyme complex |
| CORUM:2825 | 6.77906398164e-10 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | BRCA1-RNA polymerase II complex |
| KEGG:03022 | 2.02266309787e-09 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | Basal transcription factors |
| REAC:R-HSA-167161 | 1.61758895931e-08 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | HIV Transcription Initiation |
| REAC:R-HSA-73779 | 1.61758895931e-08 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-76042 | 1.61758895931e-08 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-75953 | 1.61758895931e-08 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-73776 | 1.61758895931e-08 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-167162 | 1.61758895931e-08 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-167172 | 8.81174024321e-08 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 1.04350063852e-07 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 1.58621935087e-07 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-162599 | 1.12976343415e-06 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 1.64727717851e-06 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | HIV Life Cycle |
| WP:WP405 | 2.40067855039e-06 | 0.75 | GTF2E2 GTF2E1 GTF2F2 | Eukaryotic Transcription Initiation |
| CORUM:152 | 5.02777038712e-06 | 0.5 | GTF2E2 GTF2E1 | TFIIE complex |
| CORUM:153 | 5.02777038712e-06 | 0.5 | GTF2F1 GTF2F2 | TFIIF complex (transcription factor IIF) |
| REAC:R-HSA-162906 | 9.09536403708e-06 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | HIV Infection |
| GO:0042795 | 2.23681682258e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | snRNA transcription by RNA polymerase II |
| GO:0009301 | 2.37035812542e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | snRNA transcription |
| GO:0016591 | 2.50979095633e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA polymerase II, holoenzyme |
| REAC:R-HSA-5663205 | 6.10347103542e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | Infectious disease |
| GO:0055029 | 8.10410789889e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 8.45267167948e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | DNA-directed RNA polymerase complex |
| GO:0030880 | 9.56604850625e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA polymerase complex |
| GO:0098781 | 9.96052473331e-05 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | ncRNA transcription |
| GO:0016251 | 0.000103844122491 | 0.75 | GTF2E2 GTF2E1 GTF2F1 | RNA polymerase II general transcription initiation factor activity |
| GO:0140223 | 0.000296207880886 | 0.75 | GTF2E2 GTF2E1 GTF2F1 | general transcription initiation factor activity |
| GO:0090575 | 0.000443117561019 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA polymerase II transcription factor complex |
| CORUM:3064 | 0.000527301616081 | 0.5 | GTF2F1 GTF2E1 | RNA polymerase II complex, chromatin structure modifying |
| CORUM:2685 | 0.000682858782186 | 0.5 | GTF2F1 GTF2F2 | RNA polymerase II (RNAPII) |
| GO:0006367 | 0.000819333954364 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | transcription initiation from RNA polymerase II promoter |
| GO:0044798 | 0.000921003798055 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | nuclear transcription factor complex |
| REAC:R-HSA-8851708 | 0.00171688133139 | 0.5 | GTF2F1 GTF2F2 | Signaling by FGFR2 IIIa TM |
| GO:0006352 | 0.00188428573822 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | DNA-templated transcription, initiation |
| GO:0005669 | 0.00217043933003 | 0.75 | GTF2E2 GTF2E1 GTF2F1 | transcription factor TFIID complex |
| GO:0061695 | 0.00244665292597 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-167242 | 0.00253927088831 | 0.5 | GTF2F1 GTF2F2 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| GO:0005674 | 0.00270494046827 | 0.5 | GTF2F1 GTF2F2 | transcription factor TFIIF complex |
| GO:0005673 | 0.00270494046827 | 0.5 | GTF2E2 GTF2E1 | transcription factor TFIIE complex |
| REAC:R-HSA-1839126 | 0.00301045354831 | 0.5 | GTF2F1 GTF2F2 | FGFR2 mutant receptor activation |
| REAC:R-HSA-1643685 | 0.00304553054305 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | Disease |
| REAC:R-HSA-6803529 | 0.00326103241616 | 0.5 | GTF2F1 GTF2F2 | FGFR2 alternative splicing |
| REAC:R-HSA-167160 | 0.00352159938331 | 0.5 | GTF2F1 GTF2F2 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-77075 | 0.00352159938331 | 0.5 | GTF2F1 GTF2F2 | RNA Pol II CTD phosphorylation and interaction with CE |
| GO:0005667 | 0.00406662724791 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | transcription factor complex |
| REAC:R-HSA-72086 | 0.00407268683926 | 0.5 | GTF2F1 GTF2F2 | mRNA Capping |
| REAC:R-HSA-167238 | 0.00497416142364 | 0.5 | GTF2F1 GTF2F2 | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 0.00497416142364 | 0.5 | GTF2F1 GTF2F2 | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-113418 | 0.00529460041948 | 0.5 | GTF2F1 GTF2F2 | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 0.00529460041948 | 0.5 | GTF2F1 GTF2F2 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-167290 | 0.00562500866147 | 0.5 | GTF2F1 GTF2F2 | Pausing and recovery of HIV elongation |
| REAC:R-HSA-5655253 | 0.00562500866147 | 0.5 | GTF2F1 GTF2F2 | Signaling by FGFR2 in disease |
| REAC:R-HSA-167287 | 0.00562500866147 | 0.5 | GTF2F1 GTF2F2 | HIV elongation arrest and recovery |
| REAC:R-HSA-73857 | 0.00664358115488 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | RNA Polymerase II Transcription |
| REAC:R-HSA-168325 | 0.0078166615373 | 0.5 | GTF2F1 GTF2F2 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-167246 | 0.00947680746611 | 0.5 | GTF2F1 GTF2F2 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167169 | 0.00947680746611 | 0.5 | GTF2F1 GTF2F2 | HIV Transcription Elongation |
| REAC:R-HSA-167200 | 0.00947680746611 | 0.5 | GTF2F1 GTF2F2 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-74160 | 0.0102868657133 | 1.0 | GTF2E2 GTF2F1 GTF2E1 GTF2F2 | Gene expression (Transcription) |
| REAC:R-HSA-167152 | 0.0103665290697 | 0.5 | GTF2F1 GTF2F2 | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-72165 | 0.013274030298 | 0.5 | GTF2F1 GTF2F2 | mRNA Splicing - Minor Pathway |
| REAC:R-HSA-1226099 | 0.0137933430055 | 0.5 | GTF2F1 GTF2F2 | Signaling by FGFR in disease |
| GO:0001097 | 0.0162267366884 | 0.5 | GTF2E2 GTF2E1 | TFIIH-class transcription factor complex binding |
| REAC:R-HSA-5654738 | 0.0165385846138 | 0.5 | GTF2F1 GTF2F2 | Signaling by FGFR2 |
| REAC:R-HSA-75955 | 0.017117349746 | 0.5 | GTF2F1 GTF2F2 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 0.017117349746 | 0.5 | GTF2F1 GTF2F2 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-6796648 | 0.0189130304237 | 0.5 | GTF2F1 GTF2F2 | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-190236 | 0.0221036214141 | 0.5 | GTF2F1 GTF2F2 | Signaling by FGFR |
| KEGG:05203 | 0.03463652866 | 0.5 | GTF2E2 GTF2E1 | Viral carcinogenesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GTF2E2 | GTF2E1 | 1.0 | 0.949 | hein_WMM bioplex (GTF2E2) bioplex_WMM Guru youn_WMM hein (GTF2E2) gupta_WMM fraction |
| GTF2F2 | GTF2F1 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| GTF2E2 | GTF2F1 | 0.988 | 0.901 | youn_WMM gupta_WMM fraction |
| GTF2E1 | GTF2F1 | 0.987 | 0.902 | youn_WMM gupta_WMM fraction |
| GTF2E1 | GTF2F2 | 0.909 | 0.832 | youn_WMM gupta_WMM fraction |
| GTF2E2 | GTF2F2 | 0.718 | 0.73 | youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_00481 has an average edge precision of 0.877 which is ranked 671 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GTF2E2 | HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04413 HuMAP2_04857 HuMAP2_05709 HuMAP2_06800 |
| GTF2E1 | HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04413 HuMAP2_04857 HuMAP2_06800 |
| GTF2F2 | HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04857 |
| GTF2F1 | HuMAP2_00481 HuMAP2_00694 HuMAP2_02992 HuMAP2_04857 |