hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00483
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PLXNA3 | Plexin-A3 (Plexin-4) (Semaphorin receptor SEX) | UniProt NCBI |
| KNTC1 | Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) | UniProt NCBI |
| PMS1 | PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) | UniProt NCBI |
| PMS2 | Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) | UniProt NCBI |
| MLH1 | DNA mismatch repair protein Mlh1 (MutL protein homolog 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0032389 | 9.08185760231e-07 | 0.6 | PMS2 PMS1 MLH1 | MutLalpha complex |
| HP:0100571 | 3.40426201827e-06 | 0.6 | PMS2 PMS1 MLH1 | Cardiac diverticulum |
| CORUM:292 | 6.70868171695e-06 | 0.4 | PMS2 MLH1 | MutL-alpha complex |
| CORUM:380 | 6.70868171695e-06 | 0.4 | PMS1 MLH1 | MutL-beta complex |
| CORUM:379 | 6.70868171695e-06 | 0.4 | PMS2 MLH1 | MutL-alpha complex |
| HP:0012174 | 9.05787850785e-06 | 0.6 | PMS2 PMS1 MLH1 | Glioblastoma multiforme |
| REAC:R-HSA-5545483 | 1.34977069275e-05 | 0.4 | PMS2 MLH1 | Defective Mismatch Repair Associated With MLH1 |
| REAC:R-HSA-5632987 | 1.34977069275e-05 | 0.4 | PMS2 MLH1 | Defective Mismatch Repair Associated With PMS2 |
| CORUM:423 | 2.0123342217e-05 | 0.4 | PMS2 MLH1 | EXO1-MLH1-PMS2 complex |
| CORUM:415 | 2.0123342217e-05 | 0.4 | PMS2 MLH1 | EXO1-MLH1-PMS2 complex |
| CORUM:291 | 2.0123342217e-05 | 0.4 | PMS2 MLH1 | MSH2-MLH1-PMS2 DNA-repair initiation complex |
| CORUM:285 | 2.0123342217e-05 | 0.4 | PMS1 MLH1 | PCNA-MLH1-PMS1 complex |
| HP:0006725 | 2.14866062081e-05 | 0.6 | PMS2 PMS1 MLH1 | Pancreatic adenocarcinoma |
| HP:0010524 | 2.73198472697e-05 | 0.6 | PMS2 PMS1 MLH1 | Agnosia |
| HP:0002893 | 2.73198472697e-05 | 0.6 | PMS2 PMS1 MLH1 | Pituitary adenoma |
| GO:0032300 | 3.17736949706e-05 | 0.6 | PMS2 PMS1 MLH1 | mismatch repair complex |
| CORUM:431 | 4.0241279111e-05 | 0.4 | PMS2 MLH1 | MSH2-MSH6-PMS2-MLH1 complex |
| CORUM:369 | 4.0241279111e-05 | 0.4 | PMS2 MLH1 | MSH2-MSH6-PMS2-MLH1 complex |
| CORUM:370 | 4.0241279111e-05 | 0.4 | PMS1 MLH1 | MSH2-MSH6-PMS1-MLH1 complex |
| CORUM:290 | 4.0241279111e-05 | 0.4 | PMS2 MLH1 | MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex |
| HP:0100576 | 4.63036319887e-05 | 0.6 | PMS2 PMS1 MLH1 | Amaurosis fugax |
| HP:0100743 | 5.09288575021e-05 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the rectum |
| HP:0011750 | 5.09288575021e-05 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the anterior pituitary |
| HP:0040277 | 5.09288575021e-05 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the pituitary gland |
| HP:0009733 | 5.58518220376e-05 | 0.6 | PMS2 PMS1 MLH1 | Glioma |
| HP:0030067 | 6.66279335018e-05 | 0.6 | PMS2 PMS1 MLH1 | Peripheral primitive neuroectodermal neoplasm |
| HP:0100613 | 6.66279335018e-05 | 0.6 | PMS2 PMS1 MLH1 | Death in early adulthood |
| HP:0004376 | 6.66279335018e-05 | 0.6 | PMS2 PMS1 MLH1 | Neuroblastic tumor |
| HP:0003006 | 6.66279335018e-05 | 0.6 | PMS2 PMS1 MLH1 | Neuroblastoma |
| CORUM:376 | 6.7059790554e-05 | 0.4 | PMS2 MLH1 | PCNA-MutS-alpha-MutL-alpha-DNA complex |
| HP:0010526 | 7.24995537039e-05 | 0.6 | PMS2 PMS1 MLH1 | Dysgraphia |
| HP:0003003 | 7.24995537039e-05 | 0.6 | PMS2 PMS1 MLH1 | Colon cancer |
| HP:0030065 | 7.87058594756e-05 | 0.6 | PMS2 PMS1 MLH1 | Primitive neuroectodermal tumor |
| REAC:R-HSA-5423599 | 0.000134922692372 | 0.4 | PMS2 MLH1 | Diseases of Mismatch Repair (MMR) |
| HP:0002671 | 0.00014151146773 | 0.6 | PMS2 PMS1 MLH1 | Basal cell carcinoma |
| HP:0200008 | 0.00014151146773 | 0.6 | PMS2 PMS1 MLH1 | Intestinal polyposis |
| HP:0001402 | 0.000171700780036 | 0.6 | PMS2 PMS1 MLH1 | Hepatocellular carcinoma |
| HP:0005266 | 0.000194037496444 | 0.6 | PMS2 PMS1 MLH1 | Intestinal polyp |
| HP:0100273 | 0.000194037496444 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the colon |
| HP:0100615 | 0.000272465709143 | 0.6 | PMS2 PMS1 MLH1 | Ovarian neoplasm |
| HP:0100031 | 0.000272465709143 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the thyroid gland |
| HP:0030063 | 0.000287298458388 | 0.6 | PMS2 PMS1 MLH1 | Neuroepithelial neoplasm |
| HP:0030061 | 0.000302658877703 | 0.6 | PMS2 PMS1 MLH1 | Neuroectodermal neoplasm |
| HP:0030060 | 0.000302658877703 | 0.6 | PMS2 PMS1 MLH1 | Nervous tissue neoplasm |
| HP:0100836 | 0.000351997622505 | 0.6 | PMS2 PMS1 MLH1 | Malignant neoplasm of the central nervous system |
| HP:0010622 | 0.000387696092352 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the skeletal system |
| HP:0012640 | 0.000406414519902 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of intracranial pressure |
| HP:0002516 | 0.000406414519902 | 0.6 | PMS2 PMS1 MLH1 | Increased intracranial pressure |
| HP:0100834 | 0.000406414519902 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the large intestine |
| HP:0100835 | 0.000531468488208 | 0.6 | PMS2 PMS1 MLH1 | Benign neoplasm of the central nervous system |
| HP:0002894 | 0.000554519771166 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the pancreas |
| HP:0000997 | 0.000696775152219 | 0.4 | PMS2 MLH1 | Axillary freckling |
| HP:0002034 | 0.000734739321212 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the rectum |
| HP:0002896 | 0.000853340168558 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the liver |
| HP:0010785 | 0.000853340168558 | 0.6 | PMS2 PMS1 MLH1 | Gonadal neoplasm |
| KEGG:03430 | 0.0010832092153 | 0.4 | PMS2 MLH1 | Mismatch repair |
| HP:0003401 | 0.00112737333582 | 0.6 | PMS2 PMS1 MLH1 | Paresthesia |
| REAC:R-HSA-5358565 | 0.00122631290825 | 0.4 | PMS2 MLH1 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358606 | 0.00122631290825 | 0.4 | PMS2 MLH1 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| HP:0100568 | 0.00124354263601 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the endocrine system |
| REAC:R-HSA-5358508 | 0.00141478632427 | 0.4 | PMS2 MLH1 | Mismatch Repair |
| HP:0002354 | 0.00163917495247 | 0.6 | PMS2 PMS1 MLH1 | Memory impairment |
| HP:0010786 | 0.00168769249288 | 0.6 | PMS2 PMS1 MLH1 | Urinary tract neoplasm |
| HP:0010787 | 0.00199894912552 | 0.6 | PMS2 PMS1 MLH1 | Genital neoplasm |
| HP:0002239 | 0.00205426749297 | 0.6 | PMS2 PMS1 MLH1 | Gastrointestinal hemorrhage |
| HP:0100006 | 0.00216793536231 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the central nervous system |
| HP:0011772 | 0.00240764613107 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of thyroid morphology |
| HP:0002076 | 0.00240764613107 | 0.6 | PMS2 PMS1 MLH1 | Migraine |
| HP:0100705 | 0.00266433352331 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the glial cells |
| HP:0000737 | 0.00308244473231 | 0.6 | PMS2 PMS1 MLH1 | Irritability |
| HP:0000738 | 0.0031561035898 | 0.6 | PMS2 PMS1 MLH1 | Hallucinations |
| HP:0001522 | 0.00362270778764 | 0.6 | PMS2 PMS1 MLH1 | Death in infancy |
| GO:0006298 | 0.00407078924856 | 0.6 | PMS2 PMS1 MLH1 | mismatch repair |
| HP:0004375 | 0.00422237396976 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the nervous system |
| HP:0002888 | 0.00422256197273 | 0.4 | PMS2 MLH1 | Ependymoma |
| HP:0002885 | 0.00487153229182 | 0.4 | PMS2 MLH1 | Medulloblastoma |
| GO:1990391 | 0.0049400991777 | 0.6 | PMS2 PMS1 MLH1 | DNA repair complex |
| KEGG:03460 | 0.00501742472281 | 0.4 | PMS2 MLH1 | Fanconi anemia pathway |
| HP:0007379 | 0.00518810524287 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the genitourinary tract |
| HP:0008069 | 0.00529202687437 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the skin |
| HP:0000763 | 0.00529202687437 | 0.6 | PMS2 PMS1 MLH1 | Sensory neuropathy |
| HP:0001123 | 0.00572151472074 | 0.6 | PMS2 PMS1 MLH1 | Visual field defect |
| HP:0012114 | 0.00630809873773 | 0.4 | PMS2 MLH1 | Endometrial carcinoma |
| HP:0002250 | 0.00652760684787 | 0.6 | PMS2 PMS1 MLH1 | Abnormal large intestine morphology |
| HP:0009592 | 0.00709565752293 | 0.4 | PMS2 MLH1 | Astrocytoma |
| HP:0004374 | 0.00753710429965 | 0.6 | PMS2 PMS1 MLH1 | Hemiplegia/hemiparesis |
| HP:0100660 | 0.00767012019887 | 0.6 | PMS2 PMS1 MLH1 | Dyskinesia |
| HP:0030126 | 0.00792937512816 | 0.4 | PMS2 MLH1 | Abnormality of the endometrium |
| HP:0100707 | 0.00792937512816 | 0.4 | PMS2 MLH1 | Abnormality of the astrocytes |
| HP:0002024 | 0.00864502491522 | 0.6 | PMS2 PMS1 MLH1 | Malabsorption |
| HP:0002859 | 0.00880923289202 | 0.4 | PMS2 MLH1 | Rhabdomyosarcoma |
| HP:0000137 | 0.00954324061064 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the ovary |
| HP:0007378 | 0.0100146377786 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm of the gastrointestinal tract |
| HP:0011747 | 0.0101751301432 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the anterior pituitary |
| HP:0007018 | 0.0122356792032 | 0.6 | PMS2 PMS1 MLH1 | Attention deficit hyperactivity disorder |
| HP:0002027 | 0.0131698060475 | 0.6 | PMS2 PMS1 MLH1 | Abdominal pain |
| HP:0012503 | 0.0137523076189 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the pituitary gland |
| HP:0009728 | 0.0138999712057 | 0.4 | PMS2 MLH1 | Neoplasm of striated muscle |
| HP:0011029 | 0.0147605976923 | 0.6 | PMS2 PMS1 MLH1 | Internal hemorrhage |
| HP:0012732 | 0.0149679510763 | 0.6 | PMS2 PMS1 MLH1 | Anorectal anomaly |
| HP:0001732 | 0.0158166348953 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the pancreas |
| HP:0001824 | 0.0164736212267 | 0.6 | PMS2 PMS1 MLH1 | Weight loss |
| HP:0011420 | 0.016696561986 | 0.6 | PMS2 PMS1 MLH1 | Age of death |
| HP:0040006 | 0.016696561986 | 0.6 | PMS2 PMS1 MLH1 | Mortality/Aging |
| HP:0011028 | 0.0169214896417 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of blood circulation |
| HP:0000739 | 0.0183132582526 | 0.6 | PMS2 PMS1 MLH1 | Anxiety |
| HP:0100852 | 0.0190366563871 | 0.6 | PMS2 PMS1 MLH1 | Abnormal fear/anxiety-related behavior |
| HP:0002019 | 0.0197787034757 | 0.6 | PMS2 PMS1 MLH1 | Constipation |
| HP:0011792 | 0.0197787034757 | 0.6 | PMS2 PMS1 MLH1 | Neoplasm by histology |
| HP:0002315 | 0.0197787034757 | 0.6 | PMS2 PMS1 MLH1 | Headache |
| HP:0002672 | 0.0215275853758 | 0.4 | PMS2 MLH1 | Gastrointestinal carcinoma |
| HP:0006749 | 0.0215275853758 | 0.4 | PMS2 MLH1 | Malignant gastrointestinal tract tumors |
| REAC:R-HSA-6796648 | 0.0253191001807 | 0.4 | PMS2 MLH1 | TP53 Regulates Transcription of DNA Repair Genes |
| HP:0002376 | 0.0261117985092 | 0.6 | PMS2 PMS1 MLH1 | Developmental regression |
| HP:0000716 | 0.0261117985092 | 0.6 | PMS2 PMS1 MLH1 | Depressivity |
| HP:0000864 | 0.0264139121191 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the hypothalamus-pituitary axis |
| HP:0000736 | 0.0264139121191 | 0.6 | PMS2 PMS1 MLH1 | Short attention span |
| HP:0012378 | 0.0351008048623 | 0.6 | PMS2 PMS1 MLH1 | Fatigue |
| HP:0010784 | 0.0360671162807 | 0.4 | PMS2 MLH1 | Uterine neoplasm |
| HP:0000820 | 0.0365846413997 | 0.6 | PMS2 PMS1 MLH1 | Abnormality of the thyroid gland |
| HP:0001480 | 0.0379116132621 | 0.4 | PMS2 MLH1 | Freckling |
| HP:0007256 | 0.0404739521804 | 0.6 | PMS2 PMS1 MLH1 | Abnormal pyramidal sign |
| CORUM:0000000 | 0.0474603483533 | 1.0 | MLH1 PLXNA3 PMS2 PMS1 KNTC1 | CORUM root |
| CORUM:5669 | 0.0499494897235 | 0.2 | PLXNA3 | PlexinA3-Nrp1 complex |
| CORUM:5759 | 0.0499494897235 | 0.2 | PLXNA3 | PLXNA3-RANBPM complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PMS1 | MLH1 | 0.042 | 0.269 | hein_WMM youn_WMM hein (MLH1) gupta_WMM |
| PMS2 | MLH1 | 0.03 | 0.231 | hein_WMM hein (PMS2) |
| PLXNA3 | MLH1 | 0.021 | 0.194 | hein_WMM hein (MLH1) |
| KNTC1 | MLH1 | 0.021 | 0.185 | youn_WMM fraction |
| PMS1 | PMS2 | 0.007 | 0.005 | hein_WMM WMM_only |
| KNTC1 | PMS1 | 0.007 | 0.001 | youn_WMM WMM_only |
| PLXNA3 | PMS1 | 0.006 | 0.001 | hein_WMM WMM_only |
| PLXNA3 | KNTC1 | 0.006 | 0.004 | hein_WMM bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_00483 has an average edge precision of 0.111 which is ranked 6905 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PLXNA3 | HuMAP2_00483 |
| KNTC1 | HuMAP2_00483 HuMAP2_05736 HuMAP2_06258 HuMAP2_06333 |
| PMS1 | HuMAP2_00483 HuMAP2_03537 |
| PMS2 | HuMAP2_00483 |
| MLH1 | HuMAP2_00483 HuMAP2_03537 |