hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00484
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPLP2 | 60S acidic ribosomal protein P2 (Large ribosomal subunit protein P2) (Renal carcinoma antigen NY-REN-44) | UniProt NCBI |
| RPS15 | 40S ribosomal protein S15 (RIG protein) (Small ribosomal subunit protein uS19) | UniProt NCBI |
| RPL37A | 60S ribosomal protein L37a (Large ribosomal subunit protein eL43) | UniProt NCBI |
| RPS13 | 40S ribosomal protein S13 (Small ribosomal subunit protein uS15) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP477 | 3.37279242457e-08 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Cytoplasmic Ribosomal Proteins |
| CORUM:306 | 6.81307719831e-08 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Ribosome, cytoplasmic |
| CORUM:3055 | 1.92696594112e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Nop56p-associated pre-rRNA complex |
| KEGG:03010 | 2.052638918e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Ribosome |
| REAC:R-HSA-156902 | 2.11478682383e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Peptide chain elongation |
| REAC:R-HSA-192823 | 2.11478682383e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Viral mRNA Translation |
| REAC:R-HSA-2408557 | 2.53401411634e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Selenocysteine synthesis |
| REAC:R-HSA-72764 | 2.53401411634e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Eukaryotic Translation Termination |
| REAC:R-HSA-156842 | 2.53401411634e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Eukaryotic Translation Elongation |
| REAC:R-HSA-975956 | 2.76558694195e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-72689 | 3.55615186106e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Formation of a pool of free 40S subunits |
| REAC:R-HSA-156827 | 5.23569103583e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-1799339 | 5.43141780353e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-72706 | 5.43141780353e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-975957 | 5.83928166169e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 5.83928166169e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-2408522 | 6.05161917666e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Selenoamino acid metabolism |
| REAC:R-HSA-72737 | 6.95938708355e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Cap-dependent Translation Initiation |
| REAC:R-HSA-72613 | 6.95938708355e-07 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Eukaryotic Translation Initiation |
| REAC:R-HSA-168273 | 1.03013477297e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-168255 | 1.31165501648e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Influenza Life Cycle |
| REAC:R-HSA-168254 | 1.74039249687e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Influenza Infection |
| REAC:R-HSA-9010553 | 2.90378915736e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Regulation of expression of SLITs and ROBOs |
| REAC:R-HSA-6791226 | 3.92257636671e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 4.87252320159e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 5.98537842586e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | rRNA processing |
| REAC:R-HSA-376176 | 7.56074356572e-06 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Signaling by ROBO receptors |
| REAC:R-HSA-72766 | 2.61768581314e-05 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Translation |
| REAC:R-HSA-71291 | 5.51007535999e-05 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Metabolism of amino acids and derivatives |
| REAC:R-HSA-5663205 | 6.10347103542e-05 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Infectious disease |
| GO:0006614 | 6.2335294411e-05 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | SRP-dependent cotranslational protein targeting to membrane |
| GO:0006613 | 8.10410789889e-05 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | cotranslational protein targeting to membrane |
| GO:0022626 | 9.183406566e-05 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | cytosolic ribosome |
| GO:0045047 | 0.000112173864937 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | protein targeting to ER |
| GO:0072599 | 0.000130738130864 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | establishment of protein localization to endoplasmic reticulum |
| GO:0000184 | 0.0001570766767 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| REAC:R-HSA-422475 | 0.000258657869731 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Axon guidance |
| GO:0070972 | 0.000285834009959 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | protein localization to endoplasmic reticulum |
| GO:0003735 | 0.000373974563235 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | structural constituent of ribosome |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Metabolism of RNA |
| GO:0006612 | 0.000708715477232 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | protein targeting to membrane |
| GO:0006413 | 0.000781119283329 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | translational initiation |
| GO:0019083 | 0.000838958719738 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | viral transcription |
| GO:0044391 | 0.00100892420578 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | ribosomal subunit |
| GO:0019080 | 0.00122965619632 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | viral gene expression |
| GO:0000956 | 0.00148476668027 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | nuclear-transcribed mRNA catabolic process |
| CORUM:5380 | 0.00150522677415 | 0.5 | RPL37A RPLP2 | TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) |
| GO:0044445 | 0.00161006679656 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | cytosolic part |
| GO:0005840 | 0.00164259339851 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | ribosome |
| CORUM:338 | 0.00233184718322 | 0.5 | RPS13 RPS15 | 40S ribosomal subunit, cytoplasmic |
| CORUM:305 | 0.00264730020974 | 0.5 | RPS13 RPS15 | 40S ribosomal subunit, cytoplasmic |
| REAC:R-HSA-1266738 | 0.00270117638515 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Developmental Biology |
| REAC:R-HSA-1643685 | 0.00304553054305 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Disease |
| CORUM:308 | 0.00518326453487 | 0.5 | RPL37A RPLP2 | 60S ribosomal subunit, cytoplasmic |
| GO:0090150 | 0.005204506391 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | establishment of protein localization to membrane |
| GO:0006402 | 0.0128783441389 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | mRNA catabolic process |
| REAC:R-HSA-72695 | 0.013274030298 | 0.5 | RPS13 RPS15 | Formation of the ternary complex, and subsequently, the 43S complex |
| GO:0005925 | 0.0156937713727 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | focal adhesion |
| GO:0005924 | 0.0160529884266 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | cell-substrate adherens junction |
| GO:0006605 | 0.0167898867297 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | protein targeting |
| GO:0030055 | 0.0169780087099 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | cell-substrate junction |
| REAC:R-HSA-72649 | 0.017117349746 | 0.5 | RPS13 RPS15 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.017117349746 | 0.5 | RPS13 RPS15 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72662 | 0.0177060142151 | 0.5 | RPS13 RPS15 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0006401 | 0.0181401540934 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | RNA catabolic process |
| GO:0016032 | 0.0358963427874 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | viral process |
| REAC:R-HSA-392499 | 0.0403329683602 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Metabolism of proteins |
| GO:0005912 | 0.0433740392707 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | adherens junction |
| GO:0034655 | 0.0445306239544 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | nucleobase-containing compound catabolic process |
| REAC:R-HSA-1430728 | 0.0467536218007 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | Metabolism |
| GO:0070161 | 0.0477280075644 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | anchoring junction |
| GO:0072594 | 0.0498119083732 | 1.0 | RPL37A RPS15 RPLP2 RPS13 | establishment of protein localization to organelle |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPS13 | RPLP2 | 1.0 | 0.949 | bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPS13 | RPL37A | 1.0 | 0.949 | hein_WMM bioplex (RPL37A) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPS13 | RPS15 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo fraction boldt_WMM treiber_WMM |
| RPL37A | RPLP2 | 1.0 | 0.949 | bioplex (RPL37A) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RPL37A | RPS15 | 1.0 | 0.949 | hein_WMM bioplex (RPL37A) bioplex_WMM boldt youn_WMM Malo fraction boldt_WMM treiber_WMM |
| RPS15 | RPLP2 | 0.007 | 0.006 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_00484 has an average edge precision of 0.792 which is ranked 953 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPLP2 | HuMAP2_00484 HuMAP2_02207 HuMAP2_03749 |
| RPS15 | HuMAP2_00484 HuMAP2_02207 HuMAP2_03749 |
| RPL37A | HuMAP2_00484 HuMAP2_02207 HuMAP2_03749 HuMAP2_06227 |
| RPS13 | HuMAP2_00131 HuMAP2_00484 HuMAP2_02207 HuMAP2_03749 |