hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00485
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| STT3A | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC) | UniProt NCBI |
| EIF2AK3 | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) | UniProt NCBI |
| TMEM258 | Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258) | UniProt NCBI |
| MLEC | Malectin | UniProt NCBI |
| RPN2 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1199 | 0.000100576175246 | 0.4 | STT3A RPN2 | Oligosaccharyltransferase complex (Stt3A variant) |
| GO:0008250 | 0.000149729915117 | 0.6 | STT3A RPN2 TMEM258 | oligosaccharyltransferase complex |
| CORUM:6131 | 0.000301566439547 | 0.4 | STT3A RPN2 | SELK multiprotein complex |
| KEGG:04141 | 0.000538800909475 | 0.6 | STT3A RPN2 EIF2AK3 | Protein processing in endoplasmic reticulum |
| KEGG:00513 | 0.00269260965903 | 0.4 | STT3A RPN2 | Various types of N-glycan biosynthesis |
| KEGG:00510 | 0.00403884103568 | 0.4 | STT3A RPN2 | N-Glycan biosynthesis |
| GO:0005789 | 0.00914809389328 | 1.0 | STT3A EIF2AK3 RPN2 TMEM258 MLEC | endoplasmic reticulum membrane |
| GO:0042175 | 0.00992532516881 | 1.0 | STT3A EIF2AK3 RPN2 TMEM258 MLEC | nuclear outer membrane-endoplasmic reticulum membrane network |
| REAC:R-HSA-446203 | 0.0100880466408 | 0.6 | STT3A RPN2 MLEC | Asparagine N-linked glycosylation |
| GO:0044432 | 0.0440230022293 | 1.0 | STT3A EIF2AK3 RPN2 TMEM258 MLEC | endoplasmic reticulum part |
| GO:0006487 | 0.0452171392335 | 0.6 | STT3A RPN2 TMEM258 | protein N-linked glycosylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STT3A | RPN2 | 0.22 | 0.466 | hein_WMM bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RPN2 | EIF2AK3 | 0.138 | 0.406 | bioplex (RPN2) bioplex_WMM youn_WMM gupta_WMM |
| RPN2 | MLEC | 0.136 | 0.406 | hein_WMM bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RPN2 | TMEM258 | 0.105 | 0.37 | bioplex (RPN2) bioplex_WMM |
| EIF2AK3 | TMEM258 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| STT3A | TMEM258 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| MLEC | TMEM258 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| STT3A | EIF2AK3 | 0.006 | 0.006 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| MLEC | EIF2AK3 | 0.005 | 0.006 | bioplex_WMM gupta_WMM WMM_only |
| STT3A | MLEC | 0.004 | 0.014 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_00485 has an average edge precision of 0.168 which is ranked 6544 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| STT3A | HuMAP2_00485 HuMAP2_01092 HuMAP2_02541 HuMAP2_05631 HuMAP2_06974 |
| EIF2AK3 | HuMAP2_00485 HuMAP2_01092 HuMAP2_05631 HuMAP2_06974 |
| TMEM258 | HuMAP2_00485 HuMAP2_01092 HuMAP2_02727 HuMAP2_05631 HuMAP2_06974 |
| MLEC | HuMAP2_00485 HuMAP2_01092 HuMAP2_06974 |
| RPN2 | HuMAP2_00485 HuMAP2_01092 HuMAP2_05228 HuMAP2_05631 HuMAP2_06974 |