hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00486
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MCM7 | DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3) | UniProt NCBI |
| CCDC88C | Protein Daple (Coiled-coil domain-containing protein 88C) (Dvl-associating protein with a high frequency of leucine residues) (hDaple) (Hook-related protein 2) (HkRP2) | UniProt NCBI |
| MCM4 | DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21) | UniProt NCBI |
| PLEKHF2 | Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18) | UniProt NCBI |
| MAPRE2 | Microtubule-associated protein RP/EB family member 2 (APC-binding protein EB2) (End-binding protein 2) (EB2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2791 | 2.0123342217e-05 | 0.4 | MCM4 MCM7 | MCM4-MCM6-MCM7 complex |
| CORUM:2792 | 4.0241279111e-05 | 0.4 | MCM4 MCM7 | MCM2-MCM4-MCM6-MCM7 complex |
| CORUM:387 | 0.000100576175246 | 0.4 | MCM4 MCM7 | MCM complex |
| REAC:R-HSA-176974 | 0.000889652787086 | 0.4 | MCM4 MCM7 | Unwinding of DNA |
| WP:WP4352 | 0.00103118990123 | 0.6 | MCM4 MAPRE2 MCM7 | Ciliary landscape |
| KEGG:03030 | 0.00269260965903 | 0.4 | MCM4 MCM7 | DNA replication |
| WP:WP466 | 0.00285983596887 | 0.4 | MCM4 MCM7 | DNA Replication |
| WP:WP45 | 0.00646864373199 | 0.4 | MCM4 MCM7 | G1 to S cell cycle control |
| REAC:R-HSA-69190 | 0.00666792835349 | 0.4 | MCM4 MCM7 | DNA strand elongation |
| REAC:R-HSA-68962 | 0.00709716303977 | 0.4 | MCM4 MCM7 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.00894729002053 | 0.4 | MCM4 MCM7 | Activation of ATR in response to replication stress |
| WP:WP2446 | 0.0123508080289 | 0.4 | MCM4 MCM7 | Retinoblastoma Gene in Cancer |
| WP:WP179 | 0.0219349325413 | 0.4 | MCM4 MCM7 | Cell Cycle |
| KEGG:04110 | 0.0301730300338 | 0.4 | MCM4 MCM7 | Cell cycle |
| REAC:R-HSA-68867 | 0.0304761248659 | 0.4 | MCM4 MCM7 | Assembly of the pre-replicative complex |
| REAC:R-HSA-68949 | 0.0332320424718 | 0.4 | MCM4 MCM7 | Orc1 removal from chromatin |
| REAC:R-HSA-69002 | 0.0476518941102 | 0.4 | MCM4 MCM7 | DNA Replication Pre-Initiation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCM7 | MCM4 | 1.0 | 0.949 | hein_WMM bioplex (MCM7) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MCM4 | MAPRE2 | 0.201 | 0.451 | bioplex_WMM gupta_WMM fraction |
| MCM7 | CCDC88C | 0.131 | 0.402 | bioplex (MCM7) bioplex_WMM |
| MCM4 | PLEKHF2 | 0.029 | 0.232 | fraction |
| MCM4 | CCDC88C | 0.008 | 0.053 | bioplex_WMM WMM_only |
| PLEKHF2 | MAPRE2 | 0.007 | 0.003 | youn_WMM WMM_only |
| CCDC88C | MAPRE2 | 0.007 | 0.003 | youn_WMM WMM_only |
| MCM7 | PLEKHF2 | 0.003 | 0.014 | fraction |
| MCM7 | MAPRE2 | 0.0 | 0.01 | bioplex_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_00486 has an average edge precision of 0.235 which is ranked 5611 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MCM7 | HuMAP2_00191 HuMAP2_00486 HuMAP2_02127 HuMAP2_02643 HuMAP2_03207 HuMAP2_03737 HuMAP2_04095 HuMAP2_05922 |
| CCDC88C | HuMAP2_00486 HuMAP2_02127 HuMAP2_02643 HuMAP2_03737 HuMAP2_04095 |
| MCM4 | HuMAP2_00191 HuMAP2_00486 HuMAP2_00901 HuMAP2_02127 HuMAP2_03737 HuMAP2_05922 |
| PLEKHF2 | HuMAP2_00486 HuMAP2_03737 |
| MAPRE2 | HuMAP2_00486 HuMAP2_01478 HuMAP2_03288 HuMAP2_05017 |