hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00491
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GAREM1 | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | UniProt NCBI |
| GRAP2 | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | UniProt NCBI |
| ZSCAN21 | Zinc finger and SCAN domain-containing protein 21 (Renal carcinoma antigen NY-REN-21) (Zinc finger protein 38 homolog) (Zfp-38) | UniProt NCBI |
| DDHD2 | Phospholipase DDHD2 (EC 3.1.1.-) (DDHD domain-containing protein 2) (KIAA0725p) (SAM, WWE and DDHD domain-containing protein 1) | UniProt NCBI |
| GAB2 | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | UniProt NCBI |
| PTPN23 | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | UniProt NCBI |
| GAB1 | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | UniProt NCBI |
| TGM4 | Protein-glutamine gamma-glutamyltransferase 4 (EC 2.3.2.13) (Fibrinoligase) (Prostate transglutaminase) (Prostate-specific transglutaminase) (Transglutaminase P) (TG(P)) (TGP) (TGase P) (Transglutaminase-4) (TGase-4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3676 | 0.00628620228572 | 0.25 | GAB2 GAB1 | BDNF-TrkB Signaling |
| REAC:R-HSA-109704 | 0.0156064896573 | 0.25 | GAB2 GAB1 | PI3K Cascade |
| REAC:R-HSA-112399 | 0.0206530496387 | 0.25 | GAB2 GAB1 | IRS-mediated signalling |
| REAC:R-HSA-8853659 | 0.0206530496387 | 0.25 | GAB2 GAB1 | RET signaling |
| REAC:R-HSA-5655302 | 0.0206530496387 | 0.25 | GAB2 GAB1 | Signaling by FGFR1 in disease |
| REAC:R-HSA-2428924 | 0.0248968222949 | 0.25 | GAB2 GAB1 | IGF1R signaling cascade |
| REAC:R-HSA-2428928 | 0.0248968222949 | 0.25 | GAB2 GAB1 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-1433557 | 0.0263986242322 | 0.25 | GRAP2 GAB2 | Signaling by SCF-KIT |
| REAC:R-HSA-2404192 | 0.0263986242322 | 0.25 | GAB2 GAB1 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-74751 | 0.0279439725577 | 0.25 | GAB2 GAB1 | Insulin receptor signalling cascade |
| WP:WP69 | 0.0366375493841 | 0.25 | GRAP2 GAB2 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| WP:WP23 | 0.0477902143581 | 0.25 | GAB2 GAB1 | B Cell Receptor Signaling Pathway |
| CORUM:904 | 0.0497224828424 | 0.125 | GAB1 | SHC3-GAB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRAP2 | GAB2 | 1.0 | 0.949 | bioplex (GRAP2) bioplex_WMM |
| GAREM1 | GRAP2 | 0.98 | 0.896 | bioplex (GRAP2) bioplex_WMM |
| GRAP2 | PTPN23 | 0.979 | 0.895 | bioplex (GRAP2) bioplex_WMM |
| GAB1 | GRAP2 | 0.888 | 0.818 | bioplex (GRAP2) bioplex_WMM |
| TGM4 | GAB2 | 0.369 | 0.544 | bioplex (TGM4) bioplex_WMM |
| ZSCAN21 | GRAP2 | 0.103 | 0.366 | bioplex (GRAP2) bioplex_WMM |
| TGM4 | DDHD2 | 0.053 | 0.301 | bioplex (TGM4) bioplex_WMM |
| GAREM1 | GAB2 | 0.01 | 0.134 | bioplex_WMM WMM_only |
| GAB2 | PTPN23 | 0.01 | 0.126 | bioplex_WMM WMM_only |
| GAB1 | GAB2 | 0.01 | 0.116 | bioplex_WMM WMM_only |
| GAREM1 | PTPN23 | 0.01 | 0.101 | bioplex_WMM WMM_only |
| GAB1 | GAREM1 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| GAB1 | PTPN23 | 0.009 | 0.111 | bioplex_WMM youn_WMM WMM_only |
| ZSCAN21 | GAB2 | 0.008 | 0.075 | bioplex_WMM WMM_only |
| ZSCAN21 | GAREM1 | 0.008 | 0.065 | bioplex_WMM WMM_only |
| ZSCAN21 | PTPN23 | 0.008 | 0.042 | bioplex_WMM WMM_only |
| ZSCAN21 | GAB1 | 0.008 | 0.032 | bioplex_WMM WMM_only |
| GAB2 | DDHD2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| DDHD2 | PTPN23 | 0.007 | 0.002 | youn_WMM WMM_only |
Images
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Complex HuMAP2_00491 has an average edge precision of 0.299 which is ranked 4606 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GAREM1 | HuMAP2_00491 HuMAP2_01641 |
| GRAP2 | HuMAP2_00491 HuMAP2_01641 HuMAP2_06196 |
| ZSCAN21 | HuMAP2_00491 HuMAP2_00897 HuMAP2_01099 HuMAP2_02145 |
| DDHD2 | HuMAP2_00491 HuMAP2_05521 |
| GAB2 | HuMAP2_00491 HuMAP2_01641 HuMAP2_05521 |
| PTPN23 | HuMAP2_00491 HuMAP2_01641 HuMAP2_04541 |
| GAB1 | HuMAP2_00491 HuMAP2_01641 |
| TGM4 | HuMAP2_00491 HuMAP2_05521 |