hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00495
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PHF20 | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | UniProt NCBI |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | UniProt NCBI |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | UniProt NCBI |
| KAT8 | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF) | UniProt NCBI |
| KANSL2 | KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) | UniProt NCBI |
| MCRS1 | Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) | UniProt NCBI |
| DUS2 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7221 | 2.0646493241e-18 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | NSL complex |
| GO:0046972 | 4.85164652475e-15 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone acetyltransferase activity (H4-K16 specific) |
| GO:0043996 | 4.85164652475e-15 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone acetyltransferase activity (H4-K8 specific) |
| GO:0043995 | 4.85164652475e-15 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone acetyltransferase activity (H4-K5 specific) |
| GO:0043982 | 1.15597615235e-13 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone H4-K8 acetylation |
| GO:0043981 | 1.15597615235e-13 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone H4-K5 acetylation |
| GO:0043984 | 2.85808445453e-13 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone H4-K16 acetylation |
| GO:0010485 | 2.85808445453e-13 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | H4 histone acetyltransferase activity |
| GO:0043967 | 5.29075120199e-10 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone H4 acetylation |
| GO:0004402 | 7.48133794918e-10 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone acetyltransferase activity |
| REAC:R-HSA-3214847 | 7.84516863433e-10 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | HATs acetylate histones |
| GO:0061733 | 9.32520630106e-10 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | peptide-lysine-N-acetyltransferase activity |
| GO:0034212 | 2.29801995212e-09 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | peptide N-acetyltransferase activity |
| GO:0044545 | 4.26853511465e-09 | 0.571428571429 | KANSL1 KANSL2 MCRS1 KANSL3 | NSL complex |
| GO:0008080 | 5.4564622564e-09 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | N-acetyltransferase activity |
| GO:0000123 | 5.91082572553e-09 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone acetyltransferase complex |
| GO:0031248 | 1.24640425525e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | protein acetyltransferase complex |
| GO:1902493 | 1.24640425525e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | acetyltransferase complex |
| GO:0016410 | 1.43180479835e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | N-acyltransferase activity |
| CORUM:5386 | 1.58824360121e-08 | 0.571428571429 | KANSL1 MCRS1 PHF20 KAT8 | MLL1-WDR5 complex |
| GO:0016407 | 2.13116011423e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | acetyltransferase activity |
| REAC:R-HSA-4839726 | 3.78677718328e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | Chromatin organization |
| REAC:R-HSA-3247509 | 3.78677718328e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | Chromatin modifying enzymes |
| GO:0016573 | 4.15197125222e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone acetylation |
| GO:0018393 | 4.65175563472e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | internal peptidyl-lysine acetylation |
| GO:0006475 | 6.12451997474e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | internal protein amino acid acetylation |
| GO:0018394 | 6.4612751722e-08 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | peptidyl-lysine acetylation |
| GO:1902562 | 1.2840030418e-07 | 0.714285714286 | KANSL1 KANSL2 MCRS1 KAT8 KANSL3 | H4 histone acetyltransferase complex |
| GO:0006473 | 2.89682706438e-07 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | protein acetylation |
| GO:0043543 | 1.06238783089e-06 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | protein acylation |
| GO:0016747 | 1.13529365231e-06 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | transferase activity, transferring acyl groups other than amino-acyl groups |
| GO:0016746 | 2.31980443934e-06 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | transferase activity, transferring acyl groups |
| GO:0044665 | 1.49294898514e-05 | 0.571428571429 | KANSL1 MCRS1 PHF20 KAT8 | MLL1/2 complex |
| GO:0071339 | 1.49294898514e-05 | 0.571428571429 | KANSL1 MCRS1 PHF20 KAT8 | MLL1 complex |
| GO:0018205 | 1.63926986258e-05 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | peptidyl-lysine modification |
| GO:0016570 | 3.54428703858e-05 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | histone modification |
| GO:0016569 | 4.65172651246e-05 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | covalent chromatin modification |
| CORUM:610 | 6.04024714829e-05 | 0.285714285714 | KANSL1 KAT8 | MSL complex |
| GO:0006325 | 0.00117516939098 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | chromatin organization |
| GO:0035097 | 0.0013339504969 | 0.571428571429 | KANSL1 MCRS1 PHF20 KAT8 | histone methyltransferase complex |
| GO:1990234 | 0.00351782066073 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | transferase complex |
| GO:0034708 | 0.00433362278423 | 0.571428571429 | KANSL1 MCRS1 PHF20 KAT8 | methyltransferase complex |
| GO:0018193 | 0.0134503806881 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | peptidyl-amino acid modification |
| GO:0044451 | 0.0180209467821 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | nucleoplasm part |
| GO:0051276 | 0.0190987011465 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | chromosome organization |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | KANSL1 KANSL2 KAT8 PHF20 KANSL3 MCRS1 | CORUM root |
| CORUM:6314 | 0.0499886427319 | 0.142857142857 | MCRS1 | MSP58-RINT1 complex |
| CORUM:724 | 0.0499886427319 | 0.142857142857 | KAT8 | MAF2 complex |
| CORUM:1057 | 0.0499886427319 | 0.142857142857 | MCRS1 | DIPA-MCRS1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PHF20 | KANSL1 | 0.51 | 0.63 | bioplex (KANSL1,PHF20) bioplex_WMM |
| KAT8 | KANSL1 | 0.276 | 0.487 | hein_WMM bioplex_WMM hein (KAT8) |
| DUS2 | KANSL1 | 0.197 | 0.45 | bioplex (KANSL1) bioplex_WMM |
| KANSL2 | KANSL1 | 0.09 | 0.355 | bioplex (KANSL1) bioplex_WMM |
| KANSL3 | PHF20 | 0.065 | 0.348 | bioplex (PHF20) bioplex_WMM |
| MCRS1 | KANSL1 | 0.055 | 0.311 | hein_WMM bioplex (KANSL1) bioplex_WMM |
| KANSL2 | PHF20 | 0.038 | 0.263 | bioplex (PHF20) bioplex_WMM |
| KAT8 | KANSL3 | 0.03 | 0.23 | hein_WMM bioplex_WMM hein (KAT8) |
| PHF20 | MCRS1 | 0.02 | 0.185 | bioplex (PHF20) bioplex_WMM |
| KAT8 | MCRS1 | 0.016 | 0.164 | hein_WMM bioplex_WMM hein (KAT8) |
| KAT8 | PHF20 | 0.016 | 0.16 | bioplex (PHF20) bioplex_WMM |
| KANSL2 | MCRS1 | 0.013 | 0.143 | bioplex_WMM Guru fraction boldt_WMM |
| PHF20 | DUS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| KANSL3 | KANSL1 | 0.008 | 0.088 | hein_WMM bioplex_WMM WMM_only |
| KANSL2 | DUS2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| MCRS1 | DUS2 | 0.008 | 0.02 | bioplex_WMM WMM_only |
| KANSL3 | KANSL2 | 0.008 | 0.012 | bioplex_WMM WMM_only |
| KAT8 | KANSL2 | 0.008 | 0.012 | bioplex_WMM WMM_only |
| KANSL3 | MCRS1 | 0.007 | 0.011 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00495 has an average edge precision of 0.212 which is ranked 5992 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PHF20 | HuMAP2_00495 HuMAP2_04164 HuMAP2_04368 HuMAP2_05472 |
| KANSL3 | HuMAP2_00337 HuMAP2_00495 HuMAP2_04368 HuMAP2_04911 |
| KANSL1 | HuMAP2_00495 HuMAP2_04164 HuMAP2_05472 |
| KAT8 | HuMAP2_00337 HuMAP2_00495 HuMAP2_03592 HuMAP2_05119 |
| KANSL2 | HuMAP2_00495 HuMAP2_05472 |
| MCRS1 | HuMAP2_00495 HuMAP2_05472 |
| DUS2 | HuMAP2_00495 HuMAP2_05472 |