hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00503
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BMT2 | S-adenosylmethionine sensor upstream of mTORC1 (Probable methyltransferase BMT2 homolog) (EC 2.1.1.-) | UniProt NCBI |
| DEPDC5 | GATOR complex protein DEPDC5 (DEP domain-containing protein 5) | UniProt NCBI |
| NPRL2 | GATOR complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990130 | 1.81637152046e-06 | 1.0 | NPRL2 DEPDC5 BMT2 | GATOR1 complex |
| CORUM:6215 | 1.00675659188e-05 | 0.666666666667 | DEPDC5 NPRL2 | GATOR1 complex |
| GO:0035859 | 6.17566316957e-05 | 1.0 | NPRL2 DEPDC5 BMT2 | Seh1-associated complex |
| CORUM:6217 | 9.39429153233e-05 | 0.666666666667 | DEPDC5 NPRL2 | GATOR complex |
| HP:0032046 | 0.000318128568027 | 0.666666666667 | DEPDC5 NPRL2 | Focal cortical dysplasia |
| GO:0032007 | 0.000543458358922 | 1.0 | NPRL2 DEPDC5 BMT2 | negative regulation of TOR signaling |
| GO:0034198 | 0.000648444632805 | 1.0 | NPRL2 DEPDC5 BMT2 | cellular response to amino acid starvation |
| GO:1990928 | 0.0007056603357 | 1.0 | NPRL2 DEPDC5 BMT2 | response to amino acid starvation |
| KEGG:04150 | 0.00458162707101 | 0.666666666667 | DEPDC5 NPRL2 | mTOR signaling pathway |
| GO:0032006 | 0.00746165420606 | 1.0 | NPRL2 DEPDC5 BMT2 | regulation of TOR signaling |
| GO:0031929 | 0.0117851633362 | 1.0 | NPRL2 DEPDC5 BMT2 | TOR signaling |
| GO:0009267 | 0.0146853637429 | 1.0 | NPRL2 DEPDC5 BMT2 | cellular response to starvation |
| GO:0042594 | 0.0206993698472 | 1.0 | NPRL2 DEPDC5 BMT2 | response to starvation |
| HP:0002539 | 0.0212828287434 | 0.666666666667 | DEPDC5 NPRL2 | Cortical dysplasia |
| GO:0031669 | 0.0356085105614 | 1.0 | NPRL2 DEPDC5 BMT2 | cellular response to nutrient levels |
| GO:0031668 | 0.0451949561721 | 1.0 | NPRL2 DEPDC5 BMT2 | cellular response to extracellular stimulus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DEPDC5 | NPRL2 | 0.773 | 0.752 | bioplex (DEPDC5,NPRL2) bioplex_WMM |
| DEPDC5 | BMT2 | 0.533 | 0.638 | bioplex (BMT2) bioplex_WMM |
| BMT2 | NPRL2 | 0.02 | 0.187 | bioplex (BMT2) bioplex_WMM |
Images
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Complex HuMAP2_00503 has an average edge precision of 0.526 which is ranked 2366 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BMT2 | HuMAP2_00503 HuMAP2_00701 HuMAP2_01040 HuMAP2_01293 |
| DEPDC5 | HuMAP2_00503 HuMAP2_00701 HuMAP2_01040 HuMAP2_01293 HuMAP2_04382 |
| NPRL2 | HuMAP2_00503 HuMAP2_01040 HuMAP2_01293 HuMAP2_04382 |