hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_00504

Confidence: High

Genename	Protein Name	Links
P4HB	Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)	UniProt NCBI
NUDT21	Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit)	UniProt NCBI
P4HA2	Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)	UniProt NCBI
YWHAH	14-3-3 protein eta (Protein AS1)	UniProt NCBI
YWHAZ	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)	UniProt NCBI
YWHAB	14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]	UniProt NCBI
YWHAG	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5199	1.64999296982e-09	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Kinase maturation complex 1
REAC:R-HSA-75035	2.03884182735e-09	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REAC:R-HSA-111447	3.89107916309e-09	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Activation of BAD and translocation to mitochondria
REAC:R-HSA-114452	7.7932067567e-08	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Activation of BH3-only proteins
REAC:R-HSA-109606	6.52796408062e-07	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Intrinsic Pathway for Apoptosis
REAC:R-HSA-9614399	1.75127908727e-06	0.428571428571	YWHAB YWHAZ YWHAG	Regulation of localization of FOXO transcription factors
REAC:R-HSA-1445148	2.30170723977e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Translocation of SLC2A4 (GLUT4) to the plasma membrane
REAC:R-HSA-5628897	4.46137289934e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	TP53 Regulates Metabolic Genes
KEGG:04114	4.54258153483e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Oocyte meiosis
WP:WP179	6.3872910282e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Cell Cycle
KEGG:04110	7.21558485144e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Cell cycle
WP:WP536	7.3230510088e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Calcium Regulation in the Cardiac Cell
REAC:R-HSA-5625740	8.21877381145e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	RHO GTPases activate PKNs
REAC:R-HSA-69473	8.58266296478e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	G2/M DNA damage checkpoint
WP:WP706	9.49788417783e-06	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WP:WP289	1.04264299585e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Myometrial Relaxation and Contraction Pathways
GO:1900739	1.07646157797e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740	1.07646157797e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
KEGG:05160	1.19447655628e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Hepatitis C
KEGG:04390	1.42094075825e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Hippo signaling pathway
GO:0001844	2.01980560179e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901030	3.47762626669e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
KEGG:05203	4.37888853972e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Viral carcinogenesis
GO:1901028	6.98341385223e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
REAC:R-HSA-69481	8.69344777459e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	G2/M Checkpoints
REAC:R-HSA-109581	9.11840957805e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Apoptosis
REAC:R-HSA-5357801	9.7846880833e-05	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Programmed Cell Death
GO:0051204	0.000115164588825	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	protein insertion into mitochondrial membrane
GO:0097345	0.00016496565098	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	mitochondrial outer membrane permeabilization
GO:1902110	0.00019518612601	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686	0.000229373391109	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	mitochondrial outer membrane permeabilization involved in programmed cell death
GO:0051205	0.000248057665948	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	protein insertion into membrane
GO:1902108	0.000248057665948	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0035794	0.000248057665948	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of mitochondrial membrane permeability
GO:1905710	0.000267858993773	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of membrane permeability
GO:1903749	0.000267858993773	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of establishment of protein localization to mitochondrion
KEGG:04151	0.000282169949161	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	PI3K-Akt signaling pathway
REAC:R-HSA-9614085	0.000324409256161	0.428571428571	YWHAB YWHAZ YWHAG	FOXO-mediated transcription
GO:0046902	0.000359116957816	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of mitochondrial membrane permeability
GO:1903747	0.000537283108697	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of establishment of protein localization to mitochondrion
GO:0090559	0.00057242223549	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of membrane permeability
REAC:R-HSA-69620	0.000755017672692	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Cell Cycle Checkpoints
REAC:R-HSA-195258	0.00101240038307	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	RHO GTPase Effectors
GO:2001233	0.00128212878404	0.714285714286	YWHAH YWHAB P4HB YWHAG YWHAZ	regulation of apoptotic signaling pathway
REAC:R-HSA-3700989	0.00162185785521	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Transcriptional Regulation by TP53
REAC:R-HSA-392517	0.00208509668734	0.285714285714	YWHAB YWHAZ	Rap1 signalling
GO:0008637	0.00225019801643	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	apoptotic mitochondrial changes
GO:1905477	0.00256621622647	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of protein localization to membrane
GO:0010822	0.00303783780058	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of mitochondrion organization
REAC:R-HSA-194315	0.00374244313656	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Signaling by Rho GTPases
GO:2001235	0.00449957152016	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	positive regulation of apoptotic signaling pathway
GO:0007006	0.00467022701645	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	mitochondrial membrane organization
MIRNA:hsa-miR-30d-3p	0.00762919743866	0.428571428571	YWHAZ YWHAG YWHAH	hsa-miR-30d-3p
GO:0072655	0.00785622984216	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	establishment of protein localization to mitochondrion
GO:0070585	0.00837931834451	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	protein localization to mitochondrion
REAC:R-HSA-73857	0.00848206160772	0.714285714286	YWHAH YWHAB NUDT21 YWHAG YWHAZ	RNA Polymerase II Transcription
MIRNA:hsa-miR-30e-3p	0.0100064693768	0.428571428571	YWHAZ YWHAG YWHAH	hsa-miR-30e-3p
GO:0097190	0.0104651604951	0.714285714286	YWHAH YWHAB P4HB YWHAG YWHAZ	apoptotic signaling pathway
GO:0010821	0.0117361179993	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of mitochondrion organization
GO:1905475	0.0120844889275	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	regulation of protein localization to membrane
REAC:R-HSA-199991	0.0122104245536	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Membrane Trafficking
REAC:R-HSA-74160	0.0144220896917	0.714285714286	YWHAH YWHAB NUDT21 YWHAG YWHAZ	Gene expression (Transcription)
MIRNA:hsa-miR-30a-3p	0.0145420418846	0.428571428571	YWHAZ YWHAG YWHAH	hsa-miR-30a-3p
REAC:R-HSA-5653656	0.0150589916515	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Vesicle-mediated transport
REAC:R-HSA-1640170	0.0155446721983	0.571428571429	YWHAB YWHAZ YWHAG YWHAH	Cell Cycle
CORUM:6730	0.0249993571594	0.142857142857	YWHAG	14-3-3 gamma-CXCR2 complex, unstimulated
WP:WP2037	0.0267680695584	0.285714285714	YWHAZ YWHAG	Prolactin Signaling Pathway
CORUM:0000000	0.0437772681198	0.857142857143	YWHAH NUDT21 P4HB YWHAB YWHAG YWHAZ	CORUM root
CORUM:472	0.0499886427319	0.142857142857	P4HB	Prolyl 4-hydroxylase (alpha(I)-type)
CORUM:474	0.0499886427319	0.142857142857	P4HB	Prolyl 4-hydroxylase (alpha(III)-type)

Edges

Protein 1	Protein 2	Score	Precision	Evidence
YWHAZ	YWHAB	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAZ) Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAZ	YWHAH	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAH,YWHAZ) Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAB	YWHAH	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAH) Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAH	YWHAG	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAH) Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAB	YWHAG	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM
YWHAZ	YWHAG	1.0	0.949	hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAZ) Malo gupta_WMM fraction boldt_WMM treiber_WMM
NUDT21	YWHAZ	0.983	0.899	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
P4HA2	P4HB	0.98	0.896	hein_WMM bioplex (P4HA2,P4HB) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM
P4HA2	YWHAB	0.863	0.8	bioplex (P4HA2) bioplex_WMM fraction
P4HB	YWHAZ	0.849	0.79	bioplex (P4HB) boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
NUDT21	YWHAB	0.832	0.779	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
P4HA2	YWHAZ	0.804	0.768	bioplex (P4HA2) bioplex_WMM boldt fraction boldt_WMM treiber_WMM
P4HB	YWHAB	0.74	0.739	boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
NUDT21	YWHAG	0.035	0.262	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
NUDT21	YWHAH	0.018	0.176	bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
P4HA2	YWHAH	0.006	0.006	bioplex (P4HA2) bioplex_WMM
P4HA2	YWHAG	0.006	0.008	bioplex (P4HA2) bioplex_WMM
P4HA2	NUDT21	0.005	0.011	bioplex (P4HA2) bioplex_WMM fraction
P4HB	YWHAH	0.0	0.002	boldt youn_WMM gupta_WMM fraction boldt_WMM
P4HB	NUDT21	0.0	0.002	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
P4HB	YWHAG	0.0	0.0	bioplex (P4HB) boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM

Images

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Complex HuMAP2_00504 has an average edge precision of 0.563 which is ranked 2114 out of all 6965 complexes.

Related Complexes

Genename	Complexes
P4HB	HuMAP2_00504 HuMAP2_02463 HuMAP2_02974 HuMAP2_05426
NUDT21	HuMAP2_00504 HuMAP2_01021 HuMAP2_02463 HuMAP2_05632
P4HA2	HuMAP2_00316 HuMAP2_00504 HuMAP2_02463 HuMAP2_02558 HuMAP2_04896 HuMAP2_05426
YWHAH	HuMAP2_00504 HuMAP2_02558 HuMAP2_02773 HuMAP2_02800 HuMAP2_03461 HuMAP2_04364 HuMAP2_05853 HuMAP2_06654
YWHAZ	HuMAP2_00504 HuMAP2_00724 HuMAP2_02463 HuMAP2_02558 HuMAP2_02773 HuMAP2_04364
YWHAB	HuMAP2_00504 HuMAP2_00724 HuMAP2_02463 HuMAP2_02558 HuMAP2_02773 HuMAP2_04151 HuMAP2_04364
YWHAG	HuMAP2_00504 HuMAP2_02558 HuMAP2_02773 HuMAP2_02800 HuMAP2_03461 HuMAP2_04364 HuMAP2_06654

hu.MAP 2.0: Complex View

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Complex: HuMAP2_00504