hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00505
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUZ12 | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | UniProt NCBI |
| EPOP | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | UniProt NCBI |
| EZH2 | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | UniProt NCBI |
| JARID2 | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | UniProt NCBI |
| AEBP2 | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | UniProt NCBI |
| EED | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035098 | 2.6436009994e-14 | 1.0 | SUZ12 EPOP JARID2 AEBP2 EED EZH2 | ESC/E(Z) complex |
| WP:WP2916 | 1.77323856969e-13 | 0.833333333333 | EED SUZ12 JARID2 AEBP2 EZH2 | Interactome of polycomb repressive complex 2 (PRC2) |
| CORUM:974 | 2.26981451009e-12 | 0.666666666667 | EED SUZ12 AEBP2 EZH2 | EED-EZH2 complex |
| GO:0031519 | 3.09217433437e-11 | 1.0 | SUZ12 EPOP JARID2 AEBP2 EED EZH2 | PcG protein complex |
| GO:0035097 | 9.92011275025e-10 | 1.0 | SUZ12 EPOP JARID2 AEBP2 EED EZH2 | histone methyltransferase complex |
| REAC:R-HSA-212300 | 2.24631947655e-09 | 0.833333333333 | EED SUZ12 JARID2 AEBP2 EZH2 | PRC2 methylates histones and DNA |
| GO:0034708 | 5.96607933626e-09 | 1.0 | SUZ12 EPOP JARID2 AEBP2 EED EZH2 | methyltransferase complex |
| CORUM:105 | 2.25288169953e-08 | 0.5 | EED SUZ12 EZH2 | Polycomb repressive complex 2 (PRC 2) |
| CORUM:7304 | 2.25288169953e-08 | 0.5 | EED SUZ12 EZH2 | HIC1-PCL3L-PCR2 complex |
| REAC:R-HSA-212165 | 8.24751451013e-08 | 0.833333333333 | EED SUZ12 JARID2 AEBP2 EZH2 | Epigenetic regulation of gene expression |
| HP:0001814 | 2.01758072203e-07 | 0.5 | EED SUZ12 EZH2 | Deep-set nails |
| REAC:R-HSA-3214841 | 1.15737262627e-06 | 0.666666666667 | EED SUZ12 AEBP2 EZH2 | PKMTs methylate histone lysines |
| HP:0010300 | 4.43398396567e-06 | 0.5 | EED SUZ12 EZH2 | Abnormally low-pitched voice |
| WP:WP4204 | 6.06977286255e-06 | 0.5 | EED SUZ12 EZH2 | Tumor suppressor activity of SMARCB1 |
| GO:0045814 | 6.55437615032e-06 | 0.833333333333 | EED SUZ12 JARID2 AEBP2 EZH2 | negative regulation of gene expression, epigenetic |
| HP:0001816 | 7.33401028552e-06 | 0.5 | EED SUZ12 EZH2 | Thin nail |
| CORUM:5521 | 8.39001385941e-06 | 0.333333333333 | EZH2 EED | EED-EZH polycomb complex |
| WP:WP4553 | 8.94077488385e-06 | 0.5 | EED SUZ12 EZH2 | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| GO:0046976 | 1.81582264982e-05 | 0.5 | EED SUZ12 EZH2 | histone methyltransferase activity (H3-K27 specific) |
| CORUM:1177 | 2.51655344529e-05 | 0.333333333333 | EZH2 EED | Polycomb repressive complex 4 |
| CORUM:7375 | 2.51655344529e-05 | 0.333333333333 | SUZ12 EZH2 | BRD7-EZH2-SUZ12 complex |
| CORUM:5502 | 2.51655344529e-05 | 0.333333333333 | EZH2 EED | EED-EZH-YY1 polycomb complex |
| CORUM:6910 | 2.51655344529e-05 | 0.333333333333 | EZH2 EED | EED-EZH2-PHF19 complex |
| REAC:R-HSA-8953750 | 3.54699593753e-05 | 0.5 | EED SUZ12 EZH2 | Transcriptional Regulation by E2F6 |
| HP:0001176 | 6.58664956884e-05 | 0.5 | EED SUZ12 EZH2 | Large hands |
| WP:WP2369 | 6.80401543447e-05 | 0.5 | EED EZH2 AEBP2 | Histone Modifications |
| HP:0001769 | 7.34553632007e-05 | 0.5 | EED SUZ12 EZH2 | Broad foot |
| HP:0002002 | 0.00015600923299 | 0.5 | EED SUZ12 EZH2 | Deep philtrum |
| REAC:R-HSA-8943724 | 0.000172834826973 | 0.5 | EED SUZ12 EZH2 | Regulation of PTEN gene transcription |
| REAC:R-HSA-4839726 | 0.000248724612098 | 0.666666666667 | EED SUZ12 AEBP2 EZH2 | Chromatin organization |
| REAC:R-HSA-3247509 | 0.000248724612098 | 0.666666666667 | EED SUZ12 AEBP2 EZH2 | Chromatin modifying enzymes |
| HP:0001800 | 0.000265636855275 | 0.5 | EED SUZ12 EZH2 | Hypoplastic toenails |
| WP:WP2853 | 0.000457080919886 | 0.5 | EZH2 JARID2 AEBP2 | Endoderm Differentiation |
| HP:0005616 | 0.000496744784051 | 0.5 | EED SUZ12 EZH2 | Accelerated skeletal maturation |
| GO:1990234 | 0.00052342955083 | 1.0 | SUZ12 EPOP JARID2 AEBP2 EED EZH2 | transferase complex |
| HP:0001582 | 0.000525323572597 | 0.5 | EED SUZ12 EZH2 | Redundant skin |
| WP:WP4239 | 0.000590025525062 | 0.5 | EED SUZ12 EZH2 | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0001852 | 0.000617572732129 | 0.5 | EED SUZ12 EZH2 | Sandal gap |
| HP:0011304 | 0.000650558436223 | 0.5 | EED SUZ12 EZH2 | Broad thumb |
| HP:0001609 | 0.000720000789919 | 0.5 | EED SUZ12 EZH2 | Hoarse voice |
| HP:0002213 | 0.000756496387193 | 0.5 | EED SUZ12 EZH2 | Fine hair |
| GO:0040029 | 0.000840887462586 | 0.833333333333 | EED SUZ12 JARID2 AEBP2 EZH2 | regulation of gene expression, epigenetic |
| HP:0009768 | 0.00109361304916 | 0.5 | EED SUZ12 EZH2 | Broad phalanges of the hand |
| HP:0010624 | 0.00114168764513 | 0.5 | EED SUZ12 EZH2 | Aplastic/hypoplastic toenail |
| HP:0000311 | 0.00124200653741 | 0.5 | EED SUZ12 EZH2 | Round face |
| HP:0000973 | 0.00129428949367 | 0.5 | EED SUZ12 EZH2 | Cutis laxa |
| MIRNA:hsa-miR-101-3p | 0.00140142538619 | 0.666666666667 | EED SUZ12 AEBP2 EZH2 | hsa-miR-101-3p |
| REAC:R-HSA-5619507 | 0.00144566200812 | 0.5 | EED SUZ12 EZH2 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.00144566200812 | 0.5 | EED SUZ12 EZH2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-2559580 | 0.0017268331725 | 0.5 | EED SUZ12 EZH2 | Oxidative Stress Induced Senescence |
| GO:0003682 | 0.00193535689779 | 0.833333333333 | EED SUZ12 EPOP JARID2 EZH2 | chromatin binding |
| HP:0001500 | 0.00211215101544 | 0.5 | EED SUZ12 EZH2 | Broad finger |
| MIRNA:hsa-miR-138-5p | 0.00231790315667 | 0.5 | EED SUZ12 EZH2 | hsa-miR-138-5p |
| REAC:R-HSA-6807070 | 0.00234075700106 | 0.5 | EED SUZ12 EZH2 | PTEN Regulation |
| HP:0006009 | 0.00258348091707 | 0.5 | EED SUZ12 EZH2 | Broad phalanx |
| HP:0001792 | 0.00266824580105 | 0.5 | EED SUZ12 EZH2 | Small nail |
| GO:0044451 | 0.00271725025514 | 1.0 | SUZ12 EPOP JARID2 AEBP2 EED EZH2 | nucleoplasm part |
| HP:0005622 | 0.0032158301853 | 0.5 | EED SUZ12 EZH2 | Broad long bones |
| HP:0008388 | 0.00394320526633 | 0.5 | EED SUZ12 EZH2 | Abnormal toenail morphology |
| HP:0000337 | 0.00416939096982 | 0.5 | EED SUZ12 EZH2 | Broad forehead |
| HP:0008067 | 0.00416939096982 | 0.5 | EED SUZ12 EZH2 | Abnormally lax or hyperextensible skin |
| REAC:R-HSA-74160 | 0.00435080618405 | 0.833333333333 | EED SUZ12 JARID2 AEBP2 EZH2 | Gene expression (Transcription) |
| HP:0000098 | 0.00464723136975 | 0.5 | EED SUZ12 EZH2 | Tall stature |
| HP:0002164 | 0.00556831003761 | 0.5 | EED SUZ12 EZH2 | Nail dysplasia |
| REAC:R-HSA-2559583 | 0.00631068099546 | 0.5 | EED SUZ12 EZH2 | Cellular Senescence |
| HP:0009602 | 0.00660291451448 | 0.5 | EED SUZ12 EZH2 | Abnormality of thumb phalanx |
| HP:0009774 | 0.0070826612539 | 0.5 | EED SUZ12 EZH2 | Triangular shaped phalanges of the hand |
| HP:0010719 | 0.00865912215453 | 0.5 | EED SUZ12 EZH2 | Abnormality of hair texture |
| HP:0001231 | 0.0094284178221 | 0.5 | EED SUZ12 EZH2 | Abnormal fingernail morphology |
| HP:0010647 | 0.0106650876034 | 0.5 | EED SUZ12 EZH2 | Abnormal elasticity of skin |
| REAC:R-HSA-1257604 | 0.0107857264021 | 0.5 | EED SUZ12 EZH2 | PIP3 activates AKT signaling |
| HP:0001387 | 0.0115464072696 | 0.5 | EED SUZ12 EZH2 | Joint stiffness |
| HP:0008386 | 0.0120045707958 | 0.5 | EED SUZ12 EZH2 | Aplasia/Hypoplasia of the nails |
| HP:0100490 | 0.0124745993467 | 0.5 | EED SUZ12 EZH2 | Camptodactyly of finger |
| HP:0002866 | 0.0128094019441 | 0.333333333333 | EZH2 EED | Hypoplastic iliac wing |
| HP:0001220 | 0.0129566396101 | 0.5 | EED SUZ12 EZH2 | Interphalangeal joint contracture of finger |
| GO:1902494 | 0.013185208462 | 1.0 | SUZ12 EPOP JARID2 AEBP2 EED EZH2 | catalytic complex |
| HP:0006101 | 0.0137025423856 | 0.5 | EED SUZ12 EZH2 | Finger syndactyly |
| HP:0000400 | 0.0139573410906 | 0.5 | EED SUZ12 EZH2 | Macrotia |
| GO:0070317 | 0.0140408309691 | 0.5 | EED SUZ12 EZH2 | negative regulation of G0 to G1 transition |
| HP:0000944 | 0.0144762947483 | 0.5 | EED SUZ12 EZH2 | Abnormality of the metaphysis |
| HP:0006261 | 0.014740486186 | 0.5 | EED SUZ12 EZH2 | Abnormal phalangeal joint morphology of the hand |
| HP:0005692 | 0.015007845 | 0.5 | EED SUZ12 EZH2 | Joint hyperflexibility |
| GO:0070316 | 0.0152420239566 | 0.5 | EED SUZ12 EZH2 | regulation of G0 to G1 transition |
| HP:0012785 | 0.0163927867751 | 0.5 | EED SUZ12 EZH2 | Flexion contracture of finger |
| GO:0018024 | 0.0165096938447 | 0.5 | EED SUZ12 EZH2 | histone-lysine N-methyltransferase activity |
| REAC:R-HSA-9006925 | 0.0171589759047 | 0.5 | EED SUZ12 EZH2 | Intracellular signaling by second messengers |
| GO:0045023 | 0.0178456165824 | 0.5 | EED SUZ12 EZH2 | G0 to G1 transition |
| HP:0000023 | 0.0210481336433 | 0.5 | EED SUZ12 EZH2 | Inguinal hernia |
| HP:0000368 | 0.0238534736244 | 0.5 | EED SUZ12 EZH2 | Low-set, posteriorly rotated ears |
| HP:0001761 | 0.0242205618962 | 0.5 | EED SUZ12 EZH2 | Pes cavus |
| HP:0000278 | 0.0242205618962 | 0.5 | EED SUZ12 EZH2 | Retrognathia |
| HP:0009473 | 0.0253441504586 | 0.5 | EED SUZ12 EZH2 | Joint contracture of the hand |
| GO:0042054 | 0.0312028564126 | 0.5 | EED SUZ12 EZH2 | histone methyltransferase activity |
| HP:0012385 | 0.035118668508 | 0.5 | EED SUZ12 EZH2 | Camptodactyly |
| HP:0100360 | 0.0370377024816 | 0.5 | EED SUZ12 EZH2 | Contractures of the joints of the upper limbs |
| GO:0016279 | 0.0398453744123 | 0.5 | EED SUZ12 EZH2 | protein-lysine N-methyltransferase activity |
| HP:0001382 | 0.0410803928175 | 0.5 | EED SUZ12 EZH2 | Joint hypermobility |
| GO:0016278 | 0.0422297014162 | 0.5 | EED SUZ12 EZH2 | lysine N-methyltransferase activity |
| HP:0030044 | 0.0432062865141 | 0.5 | EED SUZ12 EZH2 | Flexion contracture of digit |
| WP:WP2857 | 0.045101111668 | 0.333333333333 | AEBP2 JARID2 | Mesodermal Commitment Pathway |
| HP:0001762 | 0.0494228864492 | 0.5 | EED SUZ12 EZH2 | Talipes equinovarus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUZ12 | EZH2 | 1.0 | 0.949 | hein_WMM bioplex (SUZ12) bioplex_WMM hein (EZH2) Malo fraction |
| EZH2 | EED | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (EED,EZH2) Malo fraction |
| SUZ12 | EED | 0.999 | 0.949 | hein_WMM bioplex (SUZ12) bioplex_WMM youn_WMM hein (EED) |
| EZH2 | AEBP2 | 0.999 | 0.949 | hein_WMM bioplex (AEBP2) bioplex_WMM hein (EZH2) |
| AEBP2 | EED | 0.999 | 0.949 | hein_WMM bioplex (AEBP2) bioplex_WMM hein (EED) |
| SUZ12 | AEBP2 | 0.998 | 0.943 | hein_WMM bioplex (AEBP2,SUZ12) bioplex_WMM |
| SUZ12 | EPOP | 0.99 | 0.909 | hein_WMM bioplex (SUZ12) bioplex_WMM |
| SUZ12 | JARID2 | 0.899 | 0.824 | hein_WMM bioplex (SUZ12) bioplex_WMM fraction |
| JARID2 | AEBP2 | 0.626 | 0.678 | hein_WMM bioplex (AEBP2) bioplex_WMM |
| EPOP | EED | 0.012 | 0.146 | hein_WMM bioplex_WMM hein (EED) |
| EPOP | AEBP2 | 0.011 | 0.143 | hein_WMM bioplex_WMM WMM_only |
| EPOP | JARID2 | 0.01 | 0.125 | hein_WMM bioplex_WMM WMM_only |
| EZH2 | EPOP | 0.007 | 0.006 | hein_WMM bioplex_WMM hein (EZH2) |
| JARID2 | EED | 0.007 | 0.004 | hein_WMM bioplex_WMM hein (EED) |
| EZH2 | JARID2 | 0.005 | 0.009 | hein_WMM bioplex_WMM hein (EZH2) |
Images
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Complex HuMAP2_00505 has an average edge precision of 0.569 which is ranked 2088 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUZ12 | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| EPOP | HuMAP2_00505 HuMAP2_00802 HuMAP2_01172 HuMAP2_01790 |
| EZH2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 HuMAP2_03578 |
| JARID2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |
| AEBP2 | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |
| EED | HuMAP2_00505 HuMAP2_01172 HuMAP2_01790 |