hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00508
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | UniProt NCBI |
| GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein) | UniProt NCBI |
| RGS14 | Regulator of G-protein signaling 14 (RGS14) | UniProt NCBI |
| RGS12 | Regulator of G-protein signaling 12 (RGS12) | UniProt NCBI |
| GNAT3 | Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418594 | 2.38190731555e-07 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | G alpha (i) signalling events |
| REAC:R-HSA-392170 | 3.09448976434e-06 | 0.6 | GNAI1 GNG11 GNAT3 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-202040 | 7.0533398358e-06 | 0.6 | GNAI1 GNG11 GNAT3 | G-protein activation |
| REAC:R-HSA-388396 | 9.0422143857e-06 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | GPCR downstream signalling |
| REAC:R-HSA-392518 | 9.90965664735e-06 | 0.6 | GNAI1 GNG11 GNAT3 | Signal amplification |
| REAC:R-HSA-372790 | 1.3647934265e-05 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | Signaling by GPCR |
| CORUM:7081 | 2.0123342217e-05 | 0.4 | GNAI1 GNG11 | GNAI1-GNB1-GNG11 complex |
| CORUM:7085 | 2.0123342217e-05 | 0.4 | GNAI1 GNG11 | GNAI1-GNB5-GNG11 complex |
| CORUM:7082 | 2.0123342217e-05 | 0.4 | GNAI1 GNG11 | GNAI1-GNB2-GNG11 complex |
| CORUM:7084 | 2.0123342217e-05 | 0.4 | GNAI1 GNG11 | GNAI1-GNB4-GNG11 complex |
| CORUM:7083 | 2.0123342217e-05 | 0.4 | GNAI1 GNG11 | GNAI1-GNB3-GNG11 complex |
| REAC:R-HSA-6814122 | 2.47599987196e-05 | 0.6 | GNAI1 GNG11 GNAT3 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-418597 | 3.58634423945e-05 | 0.6 | GNAI1 GNG11 GNAT3 | G alpha (z) signalling events |
| GO:0003924 | 5.9036082881e-05 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | GTPase activity |
| REAC:R-HSA-9009391 | 0.000123638575202 | 0.6 | GNAI1 GNG11 GNAT3 | Extra-nuclear estrogen signaling |
| WP:WP536 | 0.000186709829938 | 0.6 | GNAI1 RGS14 GNG11 | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-111885 | 0.000275953181812 | 0.6 | GNAI1 GNG11 GNAT3 | Opioid Signalling |
| REAC:R-HSA-390466 | 0.000316649083447 | 0.6 | GNAI1 GNG11 GNAT3 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 0.000384877154433 | 0.6 | GNAI1 GNG11 GNAT3 | Protein folding |
| REAC:R-HSA-170670 | 0.00122631290825 | 0.4 | GNAI1 GNAT3 | Adenylate cyclase inhibitory pathway |
| REAC:R-HSA-112314 | 0.00234614610155 | 0.6 | GNAI1 GNG11 GNAT3 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:1905360 | 0.00235581550516 | 0.6 | GNAI1 GNG11 GNAT3 | GTPase complex |
| GO:0005834 | 0.00235581550516 | 0.6 | GNAI1 GNG11 GNAT3 | heterotrimeric G-protein complex |
| REAC:R-HSA-418555 | 0.00238658832736 | 0.6 | GNAI1 GNG11 GNAT3 | G alpha (s) signalling events |
| GO:0007186 | 0.00290907799633 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | G protein-coupled receptor signaling pathway |
| REAC:R-HSA-8939211 | 0.00371466203946 | 0.6 | GNAI1 GNG11 GNAT3 | ESR-mediated signaling |
| GO:0017111 | 0.00425361077725 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | nucleoside-triphosphatase activity |
| REAC:R-HSA-400042 | 0.00437263170532 | 0.4 | GNAI1 GNG11 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-76002 | 0.00484900153486 | 0.6 | GNAI1 GNG11 GNAT3 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-112315 | 0.005113781726 | 0.6 | GNAI1 GNG11 GNAT3 | Transmission across Chemical Synapses |
| GO:0016462 | 0.00595718342043 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | pyrophosphatase activity |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | Signal Transduction |
| GO:0016818 | 0.00605484060313 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 0.00605484060313 | 1.0 | GNAI1 RGS12 RGS14 GNAT3 GNG11 | hydrolase activity, acting on acid anhydrides |
| REAC:R-HSA-9006931 | 0.00634577840696 | 0.6 | GNAI1 GNG11 GNAT3 | Signaling by Nuclear Receptors |
| REAC:R-HSA-991365 | 0.00666792835349 | 0.4 | GNAI1 GNAT3 | Activation of GABAB receptors |
| REAC:R-HSA-977444 | 0.00666792835349 | 0.4 | GNAI1 GNAT3 | GABA B receptor activation |
| WP:WP35 | 0.0123508080289 | 0.4 | GNAI1 GNG11 | G Protein Signaling Pathways |
| KEGG:04727 | 0.0130921728933 | 0.4 | GNAI1 GNG11 | GABAergic synapse |
| KEGG:05032 | 0.0137641082753 | 0.4 | GNAI1 GNG11 | Morphine addiction |
| REAC:R-HSA-977443 | 0.0138877528683 | 0.4 | GNAI1 GNAT3 | GABA receptor activation |
| KEGG:04713 | 0.0162467151192 | 0.4 | GNAI1 GNG11 | Circadian entrainment |
| REAC:R-HSA-112043 | 0.0170965985867 | 0.4 | GNAI1 GNAT3 | PLC beta mediated events |
| REAC:R-HSA-112316 | 0.0172109299174 | 0.6 | GNAI1 GNG11 GNAT3 | Neuronal System |
| REAC:R-HSA-112040 | 0.017778070678 | 0.4 | GNAI1 GNAT3 | G-protein mediated events |
| KEGG:04726 | 0.0189323955438 | 0.4 | GNAI1 GNG11 | Serotonergic synapse |
| KEGG:04725 | 0.0193326076279 | 0.4 | GNAI1 GNG11 | Cholinergic synapse |
| KEGG:04724 | 0.020974746694 | 0.4 | GNAI1 GNG11 | Glutamatergic synapse |
| WP:WP3929 | 0.0250517914711 | 0.4 | GNAI1 GNG11 | Chemokine signaling pathway |
| WP:WP289 | 0.0279458043607 | 0.4 | RGS14 GNG11 | Myometrial Relaxation and Contraction Pathways |
| KEGG:04926 | 0.0301730300338 | 0.4 | GNAI1 GNG11 | Relaxin signaling pathway |
| KEGG:04728 | 0.030676003082 | 0.4 | GNAI1 GNG11 | Dopaminergic synapse |
| REAC:R-HSA-422356 | 0.0313816354582 | 0.4 | GNAI1 GNG11 | Regulation of insulin secretion |
| KEGG:04371 | 0.0322094461771 | 0.4 | GNAI1 GNG11 | Apelin signaling pathway |
| KEGG:04062 | 0.0353865382697 | 0.4 | GNAI1 GNG11 | Chemokine signaling pathway |
| KEGG:04723 | 0.0364781730982 | 0.4 | GNAI1 GNG11 | Retrograde endocannabinoid signaling |
| CORUM:7016 | 0.0499494897235 | 0.2 | GNAI1 | GNAI1-GNB3-GNGT1 complex |
| CORUM:7017 | 0.0499494897235 | 0.2 | GNAI1 | GNAI1-GNB4-GNGT1 complex |
| CORUM:7018 | 0.0499494897235 | 0.2 | GNAI1 | GNAI1-GNB5-GNGT1 complex |
| CORUM:7014 | 0.0499494897235 | 0.2 | GNAI1 | GNAI1-GNGT1-GNB1 complex |
| CORUM:6209 | 0.0499494897235 | 0.2 | GNAI1 | MT1-G(i)-RGS20 complex |
| CORUM:7086 | 0.0499494897235 | 0.2 | GNAI1 | GNAI1-GNB1-GNG12 complex |
| CORUM:7015 | 0.0499494897235 | 0.2 | GNAI1 | GNAI1-GNB2-GNGT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAI1 | RGS12 | 0.994 | 0.919 | bioplex (GNAI1) bioplex_WMM |
| GNAI1 | RGS14 | 0.956 | 0.862 | bioplex (GNAI1) bioplex_WMM |
| GNAI1 | GNAT3 | 0.593 | 0.665 | bioplex (GNAI1) bioplex_WMM |
| GNAI1 | GNG11 | 0.215 | 0.464 | bioplex (GNAI1) bioplex_WMM |
| RGS14 | GNG11 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| RGS14 | RGS12 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| GNG11 | RGS12 | 0.011 | 0.148 | bioplex_WMM WMM_only |
| RGS14 | GNAT3 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| RGS12 | GNAT3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| GNG11 | GNAT3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_00508 has an average edge precision of 0.364 which is ranked 3700 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNG11 | HuMAP2_00508 HuMAP2_01804 HuMAP2_02804 HuMAP2_04804 HuMAP2_05902 |
| GNAI1 | HuMAP2_00508 HuMAP2_01804 HuMAP2_04946 HuMAP2_05902 |
| RGS14 | HuMAP2_00508 HuMAP2_04946 HuMAP2_05902 |
| RGS12 | HuMAP2_00508 HuMAP2_01804 HuMAP2_03251 HuMAP2_03298 HuMAP2_03506 HuMAP2_04946 HuMAP2_05902 |
| GNAT3 | HuMAP2_00508 HuMAP2_04626 HuMAP2_04946 HuMAP2_05570 |