hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00512
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KRT1 | Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1) | UniProt NCBI |
| KRT10 | Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) | UniProt NCBI |
| DSP | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | UniProt NCBI |
| KRT5 | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000972 | 4.86906703925e-09 | 1.0 | DSP KRT10 KRT5 KRT1 | Palmoplantar hyperkeratosis |
| HP:0010765 | 8.38879302961e-09 | 1.0 | DSP KRT10 KRT5 KRT1 | Palmar hyperkeratosis |
| HP:0007475 | 1.22102859637e-08 | 0.75 | DSP KRT10 KRT1 | Congenital bullous ichthyosiform erythroderma |
| HP:0007556 | 1.6861842998e-08 | 1.0 | DSP KRT10 KRT5 KRT1 | Plantar hyperkeratosis |
| HP:0100872 | 1.77226783062e-07 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the plantar skin of foot |
| HP:0008066 | 1.99189758439e-07 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormal blistering of the skin |
| REAC:R-HSA-6809371 | 3.27597019928e-07 | 1.0 | DSP KRT10 KRT5 KRT1 | Formation of the cornified envelope |
| HP:0010783 | 6.81017470495e-07 | 1.0 | DSP KRT10 KRT5 KRT1 | Erythema |
| REAC:R-HSA-6805567 | 9.67478990718e-07 | 1.0 | DSP KRT10 KRT5 KRT1 | Keratinization |
| HP:0000982 | 2.47702792244e-06 | 1.0 | DSP KRT10 KRT5 KRT1 | Palmoplantar keratoderma |
| HP:0007431 | 6.17218075444e-06 | 0.75 | DSP KRT10 KRT1 | Congenital ichthyosiform erythroderma |
| HP:0040211 | 1.27342892963e-05 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the skin of the palm |
| HP:0000962 | 1.70910925981e-05 | 1.0 | DSP KRT10 KRT5 KRT1 | Hyperkeratosis |
| HP:0025092 | 2.17602308369e-05 | 0.75 | DSP KRT10 KRT1 | Epidermal acanthosis |
| HP:0100871 | 4.43930222269e-05 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the palm |
| HP:0011356 | 4.84961875424e-05 | 1.0 | DSP KRT10 KRT5 KRT1 | Regional abnormality of skin |
| GO:0070268 | 7.12285743241e-05 | 1.0 | DSP KRT10 KRT5 KRT1 | cornification |
| HP:0011368 | 8.78981341725e-05 | 1.0 | DSP KRT10 KRT5 KRT1 | Epidermal thickening |
| HP:0011124 | 8.90798039133e-05 | 0.75 | DSP KRT10 KRT1 | Abnormality of epidermal morphology |
| HP:0011122 | 9.94681514534e-05 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of skin physiology |
| HP:0001072 | 0.000131880431703 | 1.0 | DSP KRT10 KRT5 KRT1 | Thickened skin |
| HP:0011276 | 0.000224186496329 | 1.0 | DSP KRT10 KRT5 KRT1 | Vascular skin abnormality |
| GO:0031424 | 0.000228860884329 | 1.0 | DSP KRT10 KRT5 KRT1 | keratinization |
| HP:0008404 | 0.000434130330519 | 0.75 | DSP KRT5 KRT1 | Nail dystrophy |
| HP:0100780 | 0.000636114718594 | 0.5 | KRT1 KRT10 | Conjunctival hamartoma |
| GO:0030216 | 0.000800055508379 | 1.0 | DSP KRT10 KRT5 KRT1 | keratinocyte differentiation |
| HP:0008064 | 0.000940953761592 | 0.75 | DSP KRT10 KRT1 | Ichthyosis |
| GO:0018149 | 0.000943419049714 | 0.75 | DSP KRT10 KRT1 | peptide cross-linking |
| GO:0009913 | 0.0014249330287 | 1.0 | DSP KRT10 KRT5 KRT1 | epidermal cell differentiation |
| HP:0011355 | 0.00142860495839 | 1.0 | DSP KRT10 KRT5 KRT1 | Localized skin lesion |
| HP:0200097 | 0.00149887618857 | 0.5 | DSP KRT5 | Oral mucosal blisters |
| GO:0043588 | 0.00195799214531 | 1.0 | DSP KRT10 KRT5 KRT1 | skin development |
| HP:0011354 | 0.00199865992944 | 1.0 | DSP KRT10 KRT5 KRT1 | Generalized abnormality of skin |
| REAC:R-HSA-1266738 | 0.00270117638515 | 1.0 | DSP KRT10 KRT5 KRT1 | Developmental Biology |
| GO:0001533 | 0.00305917975424 | 0.75 | DSP KRT10 KRT1 | cornified envelope |
| GO:0008544 | 0.00312639352664 | 1.0 | DSP KRT10 KRT5 KRT1 | epidermis development |
| HP:0040189 | 0.00476530778748 | 0.5 | KRT1 KRT10 | Scaling skin |
| HP:0030670 | 0.00524136889643 | 0.5 | KRT1 KRT10 | Hamartoma of the orbital region |
| HP:0010568 | 0.00524136889643 | 0.5 | KRT1 KRT10 | Hamartoma of the eye |
| HP:0011138 | 0.00751536288147 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of skin adnexa morphology |
| HP:0001760 | 0.00789481350611 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the foot |
| HP:0004396 | 0.00796059020261 | 0.5 | KRT1 KRT10 | Poor appetite |
| HP:0004325 | 0.00828845477786 | 1.0 | DSP KRT10 KRT5 KRT1 | Decreased body weight |
| HP:0001155 | 0.0102449195425 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the hand |
| HP:0011123 | 0.0114887691482 | 0.75 | KRT1 KRT5 KRT10 | Inflammatory abnormality of the skin |
| GO:0005882 | 0.0123955582974 | 0.75 | DSP KRT5 KRT10 | intermediate filament |
| HP:0001019 | 0.0134847743701 | 0.5 | KRT1 KRT10 | Erythroderma |
| HP:0002817 | 0.014200391729 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the upper limb |
| HP:0100012 | 0.0142767163782 | 0.5 | KRT1 KRT10 | Neoplasm of the eye |
| HP:0002814 | 0.0159791150434 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the lower limb |
| HP:0001597 | 0.017658912488 | 0.75 | DSP KRT5 KRT1 | Abnormality of the nail |
| HP:0004323 | 0.0181593552926 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of body weight |
| HP:0002597 | 0.0204895073105 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the vasculature |
| GO:0030855 | 0.0258916606244 | 1.0 | DSP KRT10 KRT5 KRT1 | epithelial cell differentiation |
| HP:0011121 | 0.0320246870686 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of skin morphology |
| HP:0000006 | 0.0376033115951 | 1.0 | DSP KRT10 KRT5 KRT1 | Autosomal dominant inheritance |
| HP:0025032 | 0.0398318494323 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of digestive system physiology |
| HP:0000951 | 0.042726547058 | 1.0 | DSP KRT10 KRT5 KRT1 | Abnormality of the skin |
| HP:0010566 | 0.0441507593067 | 0.5 | KRT1 KRT10 | Hamartoma |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DSP | KRT1 | 0.645 | 0.687 | youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| DSP | KRT5 | 0.4 | 0.56 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT1 | KRT10 | 0.257 | 0.48 | youn_WMM gupta_WMM fraction boldt_WMM |
| DSP | KRT10 | 0.083 | 0.349 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT1 | KRT5 | 0.0 | 0.001 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT5 | KRT10 | 0.0 | 0.001 | youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_00512 has an average edge precision of 0.346 which is ranked 4042 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KRT1 | HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_04038 |
| KRT10 | HuMAP2_00512 HuMAP2_02475 |
| DSP | HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_03046 HuMAP2_04038 |
| KRT5 | HuMAP2_00172 HuMAP2_00512 HuMAP2_01048 HuMAP2_01970 HuMAP2_04038 |