hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00520
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERLIN1 | Erlin-1 (Endoplasmic reticulum lipid raft-associated protein 1) (Protein KE04) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1) (SPFH domain-containing protein 1) | UniProt NCBI |
| ERLIN2 | Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6476 | 5.02777038712e-06 | 1.0 | ERLIN2 ERLIN1 | erlin1/2-RNF170 complex |
| REAC:R-HSA-5678895 | 0.0029663845284 | 1.0 | ERLIN2 ERLIN1 | Defective CFTR causes cystic fibrosis |
| GO:0045541 | 0.00450823411379 | 1.0 | ERLIN2 ERLIN1 | negative regulation of cholesterol biosynthetic process |
| GO:0090206 | 0.00450823411379 | 1.0 | ERLIN2 ERLIN1 | negative regulation of cholesterol metabolic process |
| GO:0106119 | 0.00450823411379 | 1.0 | ERLIN2 ERLIN1 | negative regulation of sterol biosynthetic process |
| REAC:R-HSA-5619084 | 0.00477638186777 | 1.0 | ERLIN2 ERLIN1 | ABC transporter disorders |
| HP:0006380 | 0.00495905752517 | 1.0 | ERLIN2 ERLIN1 | Knee flexion contracture |
| HP:0002064 | 0.00495905752517 | 1.0 | ERLIN2 ERLIN1 | Spastic gait |
| REAC:R-HSA-382556 | 0.00812990471598 | 1.0 | ERLIN2 ERLIN1 | ABC-family proteins mediated transport |
| GO:0032933 | 0.00946729163895 | 1.0 | ERLIN2 ERLIN1 | SREBP signaling pathway |
| GO:0071501 | 0.0126230555186 | 1.0 | ERLIN2 ERLIN1 | cellular response to sterol depletion |
| GO:0006991 | 0.0162296428096 | 1.0 | ERLIN2 ERLIN1 | response to sterol depletion |
| GO:0045717 | 0.0162296428096 | 1.0 | ERLIN2 ERLIN1 | negative regulation of fatty acid biosynthetic process |
| REAC:R-HSA-5619115 | 0.0202619146601 | 1.0 | ERLIN2 ERLIN1 | Disorders of transmembrane transporters |
| GO:1902931 | 0.020287053512 | 1.0 | ERLIN2 ERLIN1 | negative regulation of alcohol biosynthetic process |
| HP:0005750 | 0.024648352588 | 1.0 | ERLIN2 ERLIN1 | Contractures of the joints of the lower limbs |
| HP:0002061 | 0.0424775836499 | 1.0 | ERLIN2 ERLIN1 | Lower limb spasticity |
| GO:0045922 | 0.0473364581948 | 1.0 | ERLIN2 ERLIN1 | negative regulation of fatty acid metabolic process |
| GO:0010894 | 0.0473364581948 | 1.0 | ERLIN2 ERLIN1 | negative regulation of steroid biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ERLIN1 | ERLIN2 | 0.53 | 0.635 | hein_WMM bioplex (ERLIN1,ERLIN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_00520 has an average edge precision of 0.635 which is ranked 1745 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ERLIN1 | HuMAP2_00297 HuMAP2_00520 HuMAP2_04947 HuMAP2_05246 |
| ERLIN2 | HuMAP2_00297 HuMAP2_00520 HuMAP2_04947 HuMAP2_05246 HuMAP2_05982 |