hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_00542
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ENAH | Protein enabled homolog | UniProt NCBI |
| PDLIM7 | PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) | UniProt NCBI |
| EVL | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | UniProt NCBI |
| VASP | Vasodilator-stimulated phosphoprotein (VASP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202433 | 3.10262114446e-06 | 0.75 | VASP ENAH EVL | Generation of second messenger molecules |
| GO:0005522 | 4.35775472874e-05 | 0.75 | VASP ENAH EVL | profilin binding |
| KEGG:04015 | 0.000226248540233 | 0.75 | VASP ENAH EVL | Rap1 signaling pathway |
| REAC:R-HSA-422475 | 0.000258657869731 | 1.0 | VASP EVL ENAH PDLIM7 | Axon guidance |
| REAC:R-HSA-202403 | 0.00026664242496 | 0.75 | VASP ENAH EVL | TCR signaling |
| GO:0007411 | 0.000921003798055 | 1.0 | VASP EVL ENAH PDLIM7 | axon guidance |
| GO:0097485 | 0.000942422491033 | 1.0 | VASP EVL ENAH PDLIM7 | neuron projection guidance |
| REAC:R-HSA-376176 | 0.00212183267287 | 0.75 | VASP ENAH EVL | Signaling by ROBO receptors |
| REAC:R-HSA-1266738 | 0.00270117638515 | 1.0 | VASP EVL ENAH PDLIM7 | Developmental Biology |
| GO:0007409 | 0.00585560377275 | 1.0 | VASP EVL ENAH PDLIM7 | axonogenesis |
| GO:0061564 | 0.00733907004762 | 1.0 | VASP EVL ENAH PDLIM7 | axon development |
| GO:0017124 | 0.0100430829723 | 0.75 | VASP ENAH EVL | SH3 domain binding |
| GO:0048667 | 0.0141513325852 | 1.0 | VASP EVL ENAH PDLIM7 | cell morphogenesis involved in neuron differentiation |
| GO:0005925 | 0.0156937713727 | 1.0 | VASP EVL ENAH PDLIM7 | focal adhesion |
| GO:0005924 | 0.0160529884266 | 1.0 | VASP EVL ENAH PDLIM7 | cell-substrate adherens junction |
| GO:0030055 | 0.0169780087099 | 1.0 | VASP EVL ENAH PDLIM7 | cell-substrate junction |
| GO:0006935 | 0.0195702718132 | 1.0 | VASP EVL ENAH PDLIM7 | chemotaxis |
| GO:0042330 | 0.0195702718132 | 1.0 | VASP EVL ENAH PDLIM7 | taxis |
| CORUM:6731 | 0.0249595281251 | 0.25 | VASP | VASP-CXCR2 complex, CXCL8 stimulated |
| GO:0048812 | 0.0251226492241 | 1.0 | VASP EVL ENAH PDLIM7 | neuron projection morphogenesis |
| GO:0120039 | 0.0280287343891 | 1.0 | VASP EVL ENAH PDLIM7 | plasma membrane bounded cell projection morphogenesis |
| GO:0048858 | 0.0288632862702 | 1.0 | VASP EVL ENAH PDLIM7 | cell projection morphogenesis |
| GO:0032990 | 0.0320836506453 | 1.0 | VASP EVL ENAH PDLIM7 | cell part morphogenesis |
| GO:0000904 | 0.0426155998333 | 1.0 | VASP EVL ENAH PDLIM7 | cell morphogenesis involved in differentiation |
| GO:0005912 | 0.0433740392707 | 1.0 | VASP EVL ENAH PDLIM7 | adherens junction |
| GO:0070161 | 0.0477280075644 | 1.0 | VASP EVL ENAH PDLIM7 | anchoring junction |
| CORUM:3160 | 0.0499140284799 | 0.25 | VASP | RIAM-VASP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ENAH | EVL | 0.998 | 0.941 | bioplex (EVL) bioplex_WMM Malo gupta_WMM fraction |
| ENAH | VASP | 0.945 | 0.856 | hein_WMM bioplex (VASP) bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM |
| VASP | EVL | 0.766 | 0.75 | bioplex (EVL,VASP) bioplex_WMM Malo fraction |
| PDLIM7 | VASP | 0.377 | 0.548 | fraction |
| ENAH | PDLIM7 | 0.029 | 0.23 | bioplex_WMM youn_WMM gupta_WMM fraction |
| PDLIM7 | EVL | 0.003 | 0.011 | fraction |
Images
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Complex HuMAP2_00542 has an average edge precision of 0.556 which is ranked 2159 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ENAH | HuMAP2_00542 HuMAP2_06959 |
| PDLIM7 | HuMAP2_00542 HuMAP2_01962 |
| EVL | HuMAP2_00542 HuMAP2_04884 HuMAP2_06959 |
| VASP | HuMAP2_00542 HuMAP2_06959 |